Amlodipine reduces blood pressure and headache frequency in cocaine-dependent outpatients.

Abstract:

:Blood pressure and headache frequency were evaluated in normotensive male and female cocaine-dependent patients (N=43) participating in a placebo-controlled, double-blind trial of amlodipine for the treatment of cocaine dependence. Amlodipine produced a significant reduction in both systolic (p=0.04) and diastolic (p=0.01) blood pressures without producing dizziness or faintness. Placebo subjects had about three times the frequency of headaches compared to the amlodipine-treated subjects (p=0.004). The high frequency of headaches reported by cocaine-dependent individuals was significantly reduced by amlodipine and may reflect improved cerebrovascular tone.

journal_name

J Psychoactive Drugs

authors

Malcolm R,Liao J,Michel M,Cochran K,Pye W,Yeager D,Halushka PV

doi

10.1080/02791072.2002.10399983

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

415-9

issue

4

eissn

0279-1072

issn

2159-9777

journal_volume

34

pub_type

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