Abstract:
:Using signs, symptoms and serum methadone levels to guide evaluation, the authors treated 164 patients in a methadone maintenance program with doses of methadone exceeding 100 mg/d. The mean dose of these higher dose (HD) patients was 211 mg/d (range 110-780 mg/d). A comparison group (C) of 101 patients was randomly selected from the general clinic population (mean dose 65 mg/d). At intake the HD group reported $153/day of heroin use versus $87/day in the C group. The HD group had more patients whose opiate of choice was an oral pharmaceutical (30% versus 2% of the C group). Sixty-three percent of the HD group had comorbid Axis I psychiatric diagnoses compared to 32% of the C group. Response to psychopharmacologic treatment was enhanced by increased methadone dose in HD patients with "refractory" psychiatric disorders. Urine toxicologies described as "before" were collected prior to increase over 100 mg/d in the HD group or at the first routine urine toxicology collection of the calendar year for the C group. These results were compared to the most recent urine toxicologies for both groups ("after"). The percentage of toxicologies positive for illicit drugs in the HD group dropped from 87% "before" to 3% "after". The C group were 54% positive "before" and 37% positive "after". We conclude that doses of methadone in excess of 100 mg/d (range 110-780 mg/d in our sample of 164 patients) are not only safe but necessary to prevent illicit opiate use, stabilize psychiatric symptoms, and diminish abuse of alcohol and benzodiazepines in many patients.
journal_name
J Psychoactive Drugsjournal_title
Journal of psychoactive drugsauthors
Maxwell S,Shinderman Mdoi
10.1080/02791072.1999.10471730subject
Has Abstractpub_date
1999-04-01 00:00:00pages
95-102issue
2eissn
0279-1072issn
2159-9777journal_volume
31pub_type
临床试验,杂志文章,随机对照试验abstract::Diseases that threaten life raise existential questions that can be a source of psychological distress. Studies with psychedelics demonstrate therapeutic effects for anxiety and depression associated with life-threatening illnesses. Ayahuasca has been proposed as a possible therapeutic agent in the treatment of psychi...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2020.1854399
更新日期:2020-12-07 00:00:00
abstract::A number of factors that coalesced in the Venus figurines of the Late Neolithic culture from Hungary have been identified with dominant hallucinatory themes, suggesting the crucial role of ecstatic religion in this culture. This article provides a review of the nature and role of hallucinogens in the ecstatic religion...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.1989.10472147
更新日期:1989-01-01 00:00:00
abstract::Research on the relationship between psychoactive substance dependence and personality disorder has been difficult to interpret. Among the reasons for this difficulty are (1) shifts in conceptualizations of these two classes of disorders, (2) markedly different findings related to age, sex, other demographic variables...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章,评审
doi:10.1080/02791072.1989.10472153
更新日期:1989-04-01 00:00:00
abstract::Methoxphenidine (MXP) was one of several NMDA antagonists marketed in 2013 to replace the recently controlled compound Methoxetamine (MXE). A steep rise in user interest was recorded, despite vendor cautioning of limited user feedback. The study presented a phenomenological analysis of MXP experiences amongst recreati...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2014.974002
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:A wide variety of somatic complications is reported or expected among cocaine users because of the adulterant levamisole. Most of the reports come from North America. METHODS:To update the data on levamisole-adulterated cocaine in European countries, we present here a synthesis of data on samples seized by ...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2014.959215
更新日期:2014-11-01 00:00:00
abstract::There has been increased recognition of the clinical treatment needs of patients with co-occurring mental and substance use disorders and the heterogeneity of this group with regard to types of substances used and mental disorders. This article examines differences between men and women diagnosed with mood or psychoti...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2003.10400512
更新日期:2003-05-01 00:00:00
abstract::A significant number of individuals with co-occurring substance abuse and mental health disorders do not engage, stay, and/or complete residential treatment. The purpose of this study is to identify factors during the initial phase of treatment which predict retention in private residential treatment for individuals w...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章,多中心研究
doi:10.1080/02791072.2013.785817
更新日期:2013-04-01 00:00:00
abstract::There is a growing body of evidence to support the use of medical cannabis as an adjunct to or substitute for prescription opiates in the treatment of chronic pain. When used in conjunction with opiates, cannabinoids lead to a greater cumulative relief of pain, resulting in a reduction in the use of opiates (and assoc...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章,评审
doi:10.1080/02791072.2012.684624
更新日期:2012-04-01 00:00:00
abstract::Contemporary research has shown that a high number of alcohol-dependent and other drug-dependent individuals have a sweet preference, specifically for foods with a high sucrose concentration. Moreover, both human and animal studies have demonstrated that in some brains the consumption of sugar-rich foods or drinks pri...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2010.10400687
更新日期:2010-06-01 00:00:00
abstract::Between 1987 and 2003, an objective measure of recent drug use from a high-risk group was collected as part of a federally-funded program called ADAM (Arrestee Drug Abuse Monitoring). The information collected as part of this project supplemented other self-report data collected across the country with the general pop...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2007.10399895
更新日期:2007-11-01 00:00:00
abstract::Cannabis is generally used to enhance mood (quality of life), but it is not known whether it has this effect in the medium to longer term. Little is currently known about the temporal sequence between cannabis use and the quality of life (QOL). Data are taken from a prospective longitudinal study of pregnant women rec...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2015.1014121
更新日期:2015-04-01 00:00:00
abstract::The current study examined the association between support and comfort derived from religion or spirituality and abstinence from illicit drugs in a sample of 43 HIV-positive injection drug users entering a methadone maintenance program. Patients with high ratings of perceived spiritual or religious support were abstin...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2001.10400467
更新日期:2001-01-01 00:00:00
abstract::Savoring has covaried inversely with cannabis problems and moderated the association between cannabis use and negative consequences related to use. Research has not yet addressed the acceptability of savoring interventions for cannabis users. The present study aimed to replicate the finding of savoring as a protective...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2020.1853284
更新日期:2020-11-22 00:00:00
abstract::The doctor-patient interaction in the methadone maintenance treatment clinic is qualitatively different from general medical settings. The patient presents with a specific request for treatment of opioid dependence, most often having already selected the methadone treatment modality, and the initial contact is centere...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章,评审
doi:10.1080/02791072.1991.10472234
更新日期:1991-04-01 00:00:00
abstract::Psychedelic plants and fungi have been used in indigenous medicinal traditions for millennia. Modern psychedelic research began when Albert Hofmann first synthesized lysergic acid diethylamide (LSD-25) in 1938. Five years later, became the first person to ingest LSD. Hofmann was unaware of the significance of his acti...
journal_title:Journal of psychoactive drugs
pub_type: 历史文章,杂志文章
doi:10.1080/02791072.2019.1606472
更新日期:2019-04-01 00:00:00
abstract::The central nervous system rewarding properties of ethanol, cocaine, and heroin may activate a common catecholaminergic reward system in the mesolimbic circuitry of the brain. Driving-under-the-influence (DUI) offenders with either alcohol- or cocaine-related problems were studied. The neuronutrients SAAVE and Tropami...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.1990.10472542
更新日期:1990-04-01 00:00:00
abstract::The purpose of this study is to describe treatment utilization and relapse and examine possible predictors of time to relapse after treatment for methamphetamine (MA) use. This analysis is based on natural history interview data from 98 subjects treated for MA use in publicly-funded programs in Los Angeles County in 1...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2000.10400231
更新日期:2000-04-01 00:00:00
abstract::The many pressing medical, psychological, legal, and ethical problems associated with substance abuse by pregnant and parenting women present daunting challenges. One approach is to adopt a legal perspective where the rights of mothers, fetuses, and children are pitted against one another in courtrooms and state legis...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章,评审
doi:10.1080/02791072.1997.10400174
更新日期:1997-01-01 00:00:00
abstract::Pregabalin is approved for the management of neuropathic pain, partial-onset seizures, and fibromyalgia. Although it is considered to have low potential for abuse, reports of misuse of pregabalin are emerging. The present study contributes to this literature by presenting preliminary evidence of pregabalin misuse. Mix...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2020.1734695
更新日期:2020-04-01 00:00:00
abstract::College students across the U.S. engage in nonmedical use of prescription stimulants (NMUPS) at increasing rates. While it has been found that use is frequently motivated by a belief that stimulants will act as a study aid, little is known about predictors of NMUPS. The present study addressed impulsivity, outcome exp...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2012.662083
更新日期:2012-01-01 00:00:00
abstract::As many as 10 million people will die annually by the year 2030 due to tobacco-related causes. While much research has focused on cigarettes, the increasing popularity of smoking hookah (water pipe) has received much less attention. Epidemiological studies have been carried out in India, Pakistan, Syria, Kuwait, and L...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2011.587707
更新日期:2011-04-01 00:00:00
abstract::Female partners of male drug users may not recognize that they are endangered by sexual transmission of human immunodeficiency virus (HIV). However, even when women acknowledge this problem, there are multiple subsequent impediments to behavior change. Chemically dependent women also have specific additional needs. Mo...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.1989.10472183
更新日期:1989-10-01 00:00:00
abstract::The authors have been able to follow up on a number of residents over the years. Most of them have frequently referred to the helpfulness of the seminars during their reentry phase. Some have sought out private counseling once they felt problems cropping up. While there is no abundance of jobs awaiting the adolescent ...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.1984.10524472
更新日期:1984-01-01 00:00:00
abstract::Smoking is the leading cause of preventable death in the United States. This public health problem is of particular concern among individuals with substance use disorders in that they smoke at a greater rate than the general public. Smoking-related illness represents a major source of preventable death in persons with...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2007.10399882
更新日期:2007-12-01 00:00:00
abstract::Given the dearth of information concerning outcomes for adolescents who have been in treatment for substance abuse and related problems, the purpose of the present article is to examine the posttreatment status of adolescents who have been in residential therapeutic communities (TCs). One-year posttreatment outcome da...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2000.10400214
更新日期:2000-01-01 00:00:00
abstract::The Aztecs in pre-Columbian Mexico used not only a large number of single hallucinogens, they also used some combinations. The present article describes reports of the use of teotlaqualli, an unction prepared from ololiuhqui and picietl, with a large number of additions. The work of the chroniclers of pre-Columbian Me...
journal_title:Journal of psychoactive drugs
pub_type: 历史文章,杂志文章
doi:10.1080/02791072.1999.10471773
更新日期:1999-10-01 00:00:00
abstract::Eighty-one subjects who used ayahuasca at least once in North America answered a lengthy set of open-ended questions and completed the 81-item After the Spiritual Experience Questionnaire. An additional 50 ayahuasca users were interviewed in person. The data for this study represent ayahuasca experience based on more ...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2012.703100
更新日期:2012-07-01 00:00:00
abstract::The purpose of this study was to investigate whether patients experiencing both a major psychiatric disorder and a concurrent substance abuse problem (dual diagnosis) manifest greater neuropsychological dysfunctions than patients experiencing a major psychiatric disorder alone. Differences in diagnostic variability an...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.1993.10472242
更新日期:1993-04-01 00:00:00
abstract::Recent prevalence studies in California indicate that perinatal alcohol and other drug use remains a serious issue for large numbers of women and their children. In response, national, state and local policymakers have taken steps to address the problem, including increasing funding for treatment services. To gauge th...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.1996.10471710
更新日期:1996-01-01 00:00:00
abstract::In 2000, the voters of California approved the Substance Abuse and Crime Prevention Act (SACPA), mandating that substance-abusing offenders who met the eligibility criteria receive treatment and not jail time. In preparation for implementation, the Santa Clara County Department of Alcohol and Drug Services Research In...
journal_title:Journal of psychoactive drugs
pub_type: 杂志文章
doi:10.1080/02791072.2004.10400053
更新日期:2004-05-01 00:00:00