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Significant linkage on chromosome 10p in families with bulimia nervosa.

Abstract：

:Bulimia nervosa (BN) is strongly familial, and additive genetic effects appear to contribute substantially to the observed familiality. In turn, behavioral components of BN, such as self-induced vomiting, are reliably measured and heritable. To identify regions of the genome harboring genetic variants conferring susceptibility to BN, we conducted a linkage analysis of multiplex families with eating disorders that were identified through a proband with BN. Linkage analysis of the entire sample of 308 families yielded a double peak, with the highest nonparametric multipoint maximum LOD score (MLS), of 2.92, on chromosome 10. Given the high heritability of self-induced vomiting and the reliability with which it can be measured, we performed linkage analysis in a subset (n=133) of families in which at least two affected relatives reported a symptom pattern that included self-induced vomiting. The highest MLS (3.39) observed was on chromosome 10, between markers D10S1430 and D10S1423. These results provide evidence of the presence of a susceptibility locus for BN on chromosome 10p. Using simulations, we demonstrate that both of these scores, 2.92 and 3.39, meet the widely accepted criterion for genomewide significance. Another region on 14q meets the criterion for genomewide suggestive linkage, with MLSs of 1.97 (full sample) and 1.75 (subset) at 62 centimorgans from p-ter.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Bulik CM,Devlin B,Bacanu SA,Thornton L,Klump KL,Fichter MM,Halmi KA,Kaplan AS,Strober M,Woodside DB,Bergen AW,Ganjei JK,Crow S,Mitchell J,Rotondo A,Mauri M,Cassano G,Keel P,Berrettini WH,Kaye WH

doi

10.1086/345801

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

200-7

issue

1

eissn

0002-9297

issn

1537-6605

pii

S0002-9297(07)60519-9

journal_volume

72

pub_type

杂志文章

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