Phylogeny of mitochondrial DNA macrohaplogroup N in India, based on complete sequencing: implications for the peopling of South Asia.

Abstract:

:To resolve the phylogeny of the autochthonous mitochondrial DNA (mtDNA) haplogroups of India and determine the relationship between the Indian and western Eurasian mtDNA pools more precisely, a diverse subset of 75 macrohaplogroup N lineages was chosen for complete sequencing from a collection of >800 control-region sequences sampled across India. We identified five new autochthonous haplogroups (R7, R8, R30, R31, and N5) and fully characterized the autochthonous haplogroups (R5, R6, N1d, U2a, U2b, and U2c) that were previously described only by first hypervariable segment (HVS-I) sequencing and coding-region restriction-fragment-length polymorphism analysis. Our findings demonstrate that the Indian mtDNA pool, even when restricted to macrohaplogroup N, harbors at least as many deepest-branching lineages as the western Eurasian mtDNA pool. Moreover, the distribution of the earliest branches within haplogroups M, N, and R across Eurasia and Oceania provides additional evidence for a three-founder-mtDNA scenario and a single migration route out of Africa.

journal_name

Am J Hum Genet

authors

Palanichamy MG,Sun C,Agrawal S,Bandelt HJ,Kong QP,Khan F,Wang CY,Chaudhuri TK,Palla V,Zhang YP

doi

10.1086/425871

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

966-78

issue

6

eissn

0002-9297

issn

1537-6605

pii

S0002-9297(07)60065-2

journal_volume

75

pub_type

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