Abstract:
:To resolve the phylogeny of the autochthonous mitochondrial DNA (mtDNA) haplogroups of India and determine the relationship between the Indian and western Eurasian mtDNA pools more precisely, a diverse subset of 75 macrohaplogroup N lineages was chosen for complete sequencing from a collection of >800 control-region sequences sampled across India. We identified five new autochthonous haplogroups (R7, R8, R30, R31, and N5) and fully characterized the autochthonous haplogroups (R5, R6, N1d, U2a, U2b, and U2c) that were previously described only by first hypervariable segment (HVS-I) sequencing and coding-region restriction-fragment-length polymorphism analysis. Our findings demonstrate that the Indian mtDNA pool, even when restricted to macrohaplogroup N, harbors at least as many deepest-branching lineages as the western Eurasian mtDNA pool. Moreover, the distribution of the earliest branches within haplogroups M, N, and R across Eurasia and Oceania provides additional evidence for a three-founder-mtDNA scenario and a single migration route out of Africa.
journal_name
Am J Hum Genetjournal_title
American journal of human geneticsauthors
Palanichamy MG,Sun C,Agrawal S,Bandelt HJ,Kong QP,Khan F,Wang CY,Chaudhuri TK,Palla V,Zhang YPdoi
10.1086/425871subject
Has Abstractpub_date
2004-12-01 00:00:00pages
966-78issue
6eissn
0002-9297issn
1537-6605pii
S0002-9297(07)60065-2journal_volume
75pub_type
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