Abstract:
:Despite the increasing use of distraction osteogenesis (DO) of the mandible, the molecular mechanisms regulating new bone formation during DO remain poorly understood. The purposes of this study were (1) to establish a unique rodent model of DO capable of outlining parameters for new bone formation at the distraction site and (2) to determine a critical-size defect to differentiate osteogenesis resulting from distraction from conventional fracture healing at the osteotomy site. Adult Sprague-Dawley rats were fitted successfully with this newly developed distraction device. Analyses demonstrated that the device could distract the rat mandible reliably to 5.1 mm with complete union. Acute intersegmental gaps of 2 mm resulted in complete bony union in a manner consistent with fracture healing, whereas 3-mm acute gaps resulted in varying degrees of bony union. Acute intersegmental gaps of 5.1 mm invariably resulted in fibrous nonunion. In summary, the authors have developed a rodent model of DO of the mandible. Their distraction protocols resulted successfully in advancement to 5.1 mm with bony consolidation. Notable fracture healing occurred at immediate intersegmental spaces as large as 3 mm. A gap of 5.1 mm was sufficient to act as a critical-size defect, resulting consistently in fibrous nonunion. These findings validate the effectiveness of this distraction device and establish the critical-size defect of a rat mandible at more than 3 mm. This novel model of DO provides an effective method of examining fundamental mechanisms responsible for new bone formation in the craniofacial skeleton.
journal_name
Ann Plast Surgjournal_title
Annals of plastic surgeryauthors
Buchman SR,Ignelzi MA Jr,Radu C,Wilensky J,Rosenthal AH,Tong L,Rhee ST,Goldstein SAdoi
10.1097/00000637-200211000-00012subject
Has Abstractpub_date
2002-11-01 00:00:00pages
511-9issue
5eissn
0148-7043issn
1536-3708pii
00000637-200211000-00012journal_volume
49pub_type
杂志文章abstract::Microneurovascular techniques make transfer of innervated soft tissue a reality. The present study investigated the sensory potential of four such donor sites: volar wrist, dorsal hand, dorsal foot, and great toe. Normal moving and static two-point discrimination values for these areas are reported. A sensory reeducat...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198908000-00007
更新日期:1989-08-01 00:00:00
abstract::A new procedure for repairing damage to the scrotum caused by Fournier's gangrene is dscribed. Complete and quick covering of the exposed testicles is important aesthetically and functionally. A distally based flap split in the middle is designed. Flap viability is ensured by an abundant blood supply and venous return...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198205000-00009
更新日期:1982-05-01 00:00:00
abstract::Circumcision is a commonly performed minor surgical procedure; however, it may lead to serious complications if performed by poorly trained health care providers. In this case report, a subglanular stricture causing a mushroom-like deformity resulting from circumcision is presented. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.SAP.0000024754.83430.05
更新日期:2003-02-01 00:00:00
abstract::Medical research has a long history of joint venture between commercial entities and nonindustry researchers. Significant concern exists among accrediting bodies for medical education and federal granting agencies that conflicts of interest (COIs) exist that affect the validity of the research. This study evaluates th...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000000672
更新日期:2016-06-01 00:00:00
abstract::Despite the advances in laser treatment of port wine stains (PWS), re-emergence of these lesions still occurs. We carried out a retrospective audit of all children that received laser treatment of PWS between 1997 and 2000 using the flashlamp-pumped dye laser with a 585-nm wavelength. Out of 110 patients treated, 15 r...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000221620.83178.fc
更新日期:2006-09-01 00:00:00
abstract::Cleidocranial dysplasia (CCD) is a rare hereditary disorder characterized by skeletal malformations and dental abnormalities. Mutations of the transcription factor RUNX2 are responsible for the pathogenesis of CCD. We present a case of a 10-year-old boy with CCD, presenting with hypoplastic clavicles, delayed closure ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/SAP.0000000000001827
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Lymphedema, a chronic disfiguring condition resulting from lymphatic dysfunction or disruption, can be difficult to accurately diagnose and manage. Of particular challenge is identifying the presence of clinically significant limb swelling through simple and noninvasive methods. Many historical and currently...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000244977.84130.cf
更新日期:2007-05-01 00:00:00
abstract::The use of the nasoalveolar molding technique (NAM) aims to reduce passively the width of the alveolar gap, while improving the AP discrepancy but also focusing on the nose. We developed a within-subjects study in which 11 infants with unilateral lip deformity and varying degrees of alveolar gaps were treated by NAM. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000259001.98869.d8
更新日期:2007-11-01 00:00:00
abstract:INTRODUCTION:Adhesions are a major cause of complications and need for repeat surgery in the hand and wrist. They are indication for tenolysis and cause prolonged need for therapy and inability to regain full hand motion. Minimizing adhesions in the hand and wrist would greatly improve surgery, by decreasing cost as we...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31827eace2
更新日期:2013-05-01 00:00:00
abstract::Simultaneous multiple free flaps have become a useful option in head and neck reconstructions. We performed a 10-year retrospective study between 2001 and 2010. There were 58 men and 1 woman. The overall mortality rate was 51.7%. The longest surviving patient is 9 years and 4 months, whereas the shortest surviving pat...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318274a49f
更新日期:2012-12-01 00:00:00
abstract::The successful release of severe contracture of the first web space depends on addition of a sufficient amount of skin. Because local skin is limited, skin grafts tend to contract, and free and pedicle flaps are bulky, further procedures are often obligatory. Expansion of the tissues of the dorsum of the hand offers a...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199105000-00009
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:Clinical infection remains a significant problem in implant-based breast reconstruction and is a physical and emotional strain to the breast reconstruction patient. Bacterial strikethrough of draping and gown material is a likely source of infection. Strategies to reduce infection in implant-based breast rec...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,随机对照试验
doi:10.1097/SAP.0000000000000086
更新日期:2014-01-01 00:00:00
abstract::In patients with difficult facial reconstructions, one of the most important requirements is to plan well, before beginning treatment. It is known that it is important to consider the aesthetic unit of the face. Each cutaneous area is to be reconstructed by a single, separate graft or flap. We present 4 patients illus...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199104000-00009
更新日期:1991-04-01 00:00:00
abstract::Incomplete unilateral cleft lips show a wide range of deformities, ranging from microform to near-complete clefts. Because there are different amounts and qualities of tissue present on the cleft and non-cleft sides, surgical approaches should make distinctions based on the remnant tissue. A new procedure using an upp...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318295dceb
更新日期:2015-03-01 00:00:00
abstract::A case of penis construction using two free flaps is presented. The urethra is constructed with an ulnar forearm flap and external coverage is provided with deltoid flap. The biggest disadvantage with radial forearm flap, which is considered to be the most ideal donor flap for penile construction, is its large and uns...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200209000-00011
更新日期:2002-09-01 00:00:00
abstract::The effect of 2 to 10 hours of tourniquet ischemia on the microcirculation of the tenuissimus muscle in 29 cats was studied by in vivo microscopy and electron microscopy. After release of the tourniquet there was immediate reperfusion and hyperemia in all muscles. Arterioles of 20 micron increased in diameter by 50% a...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198703000-00008
更新日期:1987-03-01 00:00:00
abstract::There is still controversy about the correlation of thrombocytosis and thrombosis complication. Using a rodent splenectomy-induced thrombocytosis model and a thrombogenic endothelial damage model (inverted suture resulting in an intraluminal thrombogenic adventitia of divided femoral artery), the authors investigated ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-200301000-00010
更新日期:2003-01-01 00:00:00
abstract::We report a 25-year-old woman who suffered traumatic damage to the medial malleolar area. Arteriography revealed a posterior tibial artery occlusion at the ankle. The predominant pattern of medial soleus vascularization was revealed during surgery. A reverse medial soleus flap including the posterior tibial pedicle wa...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199810000-00018
更新日期:1998-10-01 00:00:00
abstract::Locally advanced, node-positive recurrence of malignant melanoma is a harbinger of distant metastases and signifies poor prognosis. However, the clinical course may vary due to the unpredictable biology of malignant melanoma. The presented patient developed a recurrent melanoma of the scalp that eroded through the sku...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.sap.0000154033.03763.cd
更新日期:2005-05-01 00:00:00
abstract::A technique of correction of Stahl's ear is presented and is compared with other techniques reported in the literature. ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/01.SAP.0000067728.84041.96
更新日期:2004-01-01 00:00:00
abstract::An effective and practical method of oxygen administration during cosmetic facial surgery under local anesthesia is described. A large volume of oxygen is delivered directly to the nasopharynx, and partial upper airway obstruction caused by the tongue falling into the pharynx is resolved, yet the apparatus does not in...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-198606000-00014
更新日期:1986-06-01 00:00:00
abstract::We report 2 cases of patients with thumb polydactyly that were difficult to classify into either Wassel type VI with a remarkable hypoplastic metacarpal or Wassel type VII (triphalangeal thumb). The radial digit was functional but hypoplastic, and the ulnar digit presented a dominant appearance but no active motion. T...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31821b6ced
更新日期:2013-01-01 00:00:00
abstract::Keloid disease is known to have variable clinical behavior in response to therapy and there is no clinicopathologic classification that predicts such varied behavior. The aim of this study was to study the effect of excision margins and other histopathologic characteristics on keloid prognosis.Seventy-five multiethnic...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e31819b6c3a
更新日期:2010-01-01 00:00:00
abstract::This paper studies the healing effect of recombinant human epidermal growth factor (EGF) on chronic diabetic foot ulcers. A total of 89 patients (65 male and 24 female) aged from 36 to 82 years (average of 54) enrolled for the prospective, open-label trial, crossover study. Predetermined criteria were used for diagnos...
journal_title:Annals of plastic surgery
pub_type: 临床试验,杂志文章
doi:10.1097/01.sap.0000198731.12407.0c
更新日期:2006-04-01 00:00:00
abstract::Reconstruction of the lower and upper lips, commissure, and full-thickness cheek defects using a composite radial forearm palmaris longus free flap with secondary commissuroplasty is described. This flap is useful for reconstruction of the total lower lip as well as larger defects that include full-thickness cheek and...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/00000637-199411000-00013
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Whether postoperative care in the intensive care unit (ICU) is a necessity for patients undergoing head and neck free flap reconstruction remains debatable. In August 2012, our institute initiated a policy to care for these patients in the ICU, opposed to the previous policy of care in the ward. Thus, we use...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0000000000001301
更新日期:2018-02-01 00:00:00
abstract::A new genioplasty technique has been described and performed on 16 patients since 1995. The technique has been developed to avoid some undesired results of the current osseous genioplasty techniques and to achieve a more natural appearance in advancement genioplasty. According to the authors' technique, a rectangular ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract::Various techniques and modifications have been introduced in the treatment of mandibular prognathism. However, there are still few reports concerning long-term stability, especially using the intraoral vertical ramus osteotomy (IVRO) method. The purpose of this study was to investigate the long-term stability for corr...
journal_title:Annals of plastic surgery
pub_type: 杂志文章
doi:10.1097/SAP.0b013e318153f3ee
更新日期:2008-07-01 00:00:00
abstract::Pilar leiomyoma is a benign smooth muscle tumor arising from the arrectores pili muscles associated with the hair follicles of the skin. The multiple biopsies and pathological consultations needed to obtain a diagnosis attest to the rarity of the disease and the difficult histological picture, which often requires an ...
journal_title:Annals of plastic surgery
pub_type: 杂志文章,评审
doi:10.1097/00000637-200045060-00018
更新日期:2000-12-01 00:00:00
abstract::Melanoma excision requires wide margins, leaving large defects. Surgical dogma has taught that definitive reconstruction of melanoma defects be performed after permanent pathology results, with skin grafts favored. However, this results in an open wound and the need for a second operation. The advantages of immediate ...
journal_title:Annals of plastic surgery
pub_type: 临床试验,杂志文章
doi:10.1097/SAP.0000000000000166
更新日期:2014-05-01 00:00:00