The influence of surgical excision margins on keloid prognosis.

Abstract:

:Keloid disease is known to have variable clinical behavior in response to therapy and there is no clinicopathologic classification that predicts such varied behavior. The aim of this study was to study the effect of excision margins and other histopathologic characteristics on keloid prognosis.Seventy-five multiethnic patients presenting with keloid scars at a department of plastic and reconstructive surgery during an 11-year period were included in this study. Clinical data was collected and detailed histologic analyses using light microscopy were carried out on archived patient specimens.A detailed histopathologic examination of all tissue samples identified keloid border or margin characteristics which were classified into "circumscribed" (borders clearly-demarcated) and "infiltrative" (borders not clearly-demarcated and not easily-definable). The specific histologic findings were correlated with keloid recurrence which revealed that incomplete peripheral (P < 0.001) and deep excision margins (P < 0.001), as well as infiltrative borders (P < 0.05) were associated with higher 1-year reported recurrence rates.This study has given evidence that incomplete surgical excision are associated with higher recurrence and this may justify the practice of routine histopathologic reporting of keloid excision margins.

journal_name

Ann Plast Surg

authors

Tan KT,Shah N,Pritchard SA,McGrouther DA,Bayat A

doi

10.1097/SAP.0b013e31819b6c3a

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

55-8

issue

1

eissn

0148-7043

issn

1536-3708

journal_volume

64

pub_type

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