Abstract:
BACKGROUND:Effects of medroxyprogesterone acetate, enoxaparin and pentoxyfylline on lipid peroxidation, antioxidant defence system, paraoxonase activities, and homocysteine levels in an experimental model of spinal cord injury were investigated. METHOD:Sixty-three male albino Wistar rats were anaesthetized by 400 mg/kg chloral hydrate and divided into 5 groups. G1 (n 7) = control group provided the baseline levels. G2-G5 underwent T3-6 total laminectomies and spinal cord injuries by clip compression at T4-5 levels. Medications were applied to G3-G5 right after the injury. Hence, G2 constituted laminectomy + injury (lam+I); G3 = lam + I + medroxyprogesterone acetate (MPA), G4 = lam + I + enoxaparin (E), and G5 = lam+I+pentoxyfylline (P) groups. Animals were decapitated either at the 1st or 4th hour after injury. Tissue and blood malonyldialdehyde (MDA) and plasma homocysteine and erythrocyte superoxide dismutase (SOD) levels, and erythrocyte glutathione peroxidase (GSH-Px) and plasma paraoxonase (PON1) activities were assayed. SPSS 9.0 program was used for statistical analysis and graphics. Intergroup comparisons were made by Bonferroni corrected Mann Whitney U test ( P<0.025), and intragroups comparisons by Wilcoxon Rank test ( P<0.03). FINDINGS:In intergroup comparison, G1-G2, G1-G3, G1-G5, G2-G3, G2-G4, and G4-5 groups differed from each other for all parameters ( P<0.025, MWU) except for G4-G5 4th hour MDA levels. G1-G4 was similar for all 1st hour parameters ( P>0.025, MWU), but different for 4th hour ( P<0.025, MWU) except for GSH-Px and SOD levels. For G2-G5, all parameters for 1st and 4th hour were similar except for 4th PON1, Hcy and SOD levels. For G3-G4, all 1st hour parameters were different from each other ( P<0.025, MWU); whereas all 4th hour parameters were similar except for SOD level. For G3-G5, all parameters at 1st and 4th hour were similar except for 4th hour GSH-Px, PON1, and Hcy. In intragroup comparison, all parameters differed from each other at all times (P<0.03, WRT) except for 1st hour G4 MDA, Hcy and SOD levels compared to basal levels. INTERPRETATION:In injury groups, plasma Hcy levels decreased and PON1 activities increased as erythrocyte SOD level and GSH-Px activities decreased in parallel to increases of tissue and blood MDA levels. These changes were relatively suppressed by MPA, enoxaparin and pentoxyfylline administrations at varying degrees. Enoxaparin was the most powerful agent, particularly at 1st hour. MPA was also effective, particularly at 4th hour. Pentoxyfylline despite having slight effect at 4th hour, was not effective according to both control and injury groups. Enoxaparin and MPA can be used in the treatment of spinal cord injuries. PON1 and Hcy are helpful in monitoring the antioxidant defence system as well as SOD and GSH-Px, both in injury and medically treated groups.
journal_name
Acta Neurochir (Wien)journal_title
Acta neurochirurgicaauthors
Topsakal C,Kilic N,Erol FS,Kaplan M,Akdemir I,Tiftikci M,Gursu Fdoi
10.1007/s00701-002-0999-1subject
Has Abstractpub_date
2002-10-01 00:00:00pages
1021-31; discussion 1031issue
10eissn
0001-6268issn
0942-0940journal_volume
144pub_type
杂志文章abstract:INTRODUCTION:A 55-year-old man underwent a microvascular decompression procedure for a pharmacoresistant trigeminal neuralgia. Preoperative MRI showed a neurovascular conflict between the Vth nerve root and the superior cerebellar artery. METHODS:Dissection of the intracisternal trigeminal root was undertaken, and a p...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-009-0488-x
更新日期:2010-04-01 00:00:00
abstract::50 patients with acromegaly and carpal tunnel syndrome have been examined electrophysiologically before and after transnasal operation of the pituitary adenoma. 32 of the 50 patients (64%) had symptoms of carpal tunnel syndrome. 13 of them had neurological deficits. 28 of the examined patients had pathological neurogr...
journal_title:Acta neurochirurgica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01420508
更新日期:1986-01-01 00:00:00
abstract::A recent modification of the occipital transtentorial approach to the pineal region and medial-posterior hemisphere is described. The patient is operated upon in a lateral reclining (park bench) position with the side to undergo occipitoparietal craniotomy, slightly dependant. Following dural opening to the margins of...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01405427
更新日期:1990-01-01 00:00:00
abstract::Over the past 5 years 9 patients underwent partial or complete corpus callosotomy for treatment of medically intractable epileptic seizures. A beneficial effect of the procedure was observed in 8 patients. Criteria for performance of the procedure included CT evidence of unilateral cerebral damage and non-localized ep...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406608
更新日期:1988-01-01 00:00:00
abstract::The Spanish National Committee for Neurosurgery has recently approved a new training programme which will shortly replace the former programme, which dates from 1984. The object of this report was to evaluate training in neurosurgery in Spain under the extant programme as perceived by the residents themselves. Assessm...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-004-0459-1
更新日期:2005-04-01 00:00:00
abstract::A 34-year-old female patient suffering from right-sided facial palsy presented to our hospital. Her hearing range was within normal limits. She had undergone GKS after receiving a diagnosis of facial nerve schwannoma (FNS). On the fourth day after GKS, the patient experienced sudden onset hearing loss on the right sid...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1983-7
更新日期:2014-02-01 00:00:00
abstract::During a period of 10 years (1977-1986) 40 cases of tumour of the pineal region have been treated at the Istituto Neurologico "C. Besta"-of Milan. Out of these 40 cases, 27 (67.5%) were in the paediatric (10-15 years) or juvenile (15-20 years) age at the time of operation. Since 1983 a specific diagnostic and therapeu...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01403491
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Dystonia has been treated well using deep brain stimulation at the globus pallidus internus (GPi DBS). Dystonia can be categorized as two basic types of movement, phasic-type and tonic-type. Cervical dystonia is the most common type of focal dystonia, and sequential differences in clinical outcomes between p...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-015-2646-7
更新日期:2016-01-01 00:00:00
abstract::Forty-two patients with petroclival meningioma were operated upon by the middle fossa transpetrosal-transtentorial approaches since 1977. Half of those showed tumour extension into the middle fossa and one-third in the cavernous sinus. Seventeen (40%) had a large tumour of 40 mm in diameter or larger, and 8 of those h...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406489
更新日期:1994-01-01 00:00:00
abstract::Large multicenter studies have recently provided long-term results substantiating the superiority of surgical as compared to conservative treatment for symptomatic and asymptomatic extracranial internal carotid stenoses of more than 70%. These results led to an increase in the frequency of thrombo-endarteriectomies. H...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010050195
更新日期:1998-01-01 00:00:00
abstract::Stereotactic targeting of the postero-ventral pallidum (PVP) presents special challenges to the surgeon 1) The target is in intimate relation to the optic tract and the internal capsule. 2) Proper angulation of the trajectory is crucial to achieve optimal effects given the long craniocaudal extension of the PVP. 3) Th...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01411480
更新日期:1996-01-01 00:00:00
abstract::A new atraumatic method for patency and blood flow control of microvascular anastomoses has been developed. Sounds proximal and distal to a suture line are separately detected by means of two specially modified miniature microphones built together as an auscultation unit and named a diplo-microphone. Transmission of t...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF02074518
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:There are conflicting opinions regarding the optimal waiting time to perform surgery after rupture of supratentorial arteriovenous malformations (AVMs) to achieve the best possible outcome. OBJECTIVE:To analyze factors influencing outcomes for ruptured supratentorial AVMs after surgery, paying particular at...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-017-3315-9
更新日期:2017-11-01 00:00:00
abstract::The clinical features of 6 children who are probable sufferers of "unilateral" Moyamoya disease are here reported. They showed angiographic findings which were compatible with those of Moyamoya disease, albeit only on one side. They did not, however, show any basic aetiologic factors. The age of onset, the clinical sy...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01808612
更新日期:1994-01-01 00:00:00
abstract::Venous malformations in the posterior fossa are relatively rare. Although the introduction of CT and MRI has made them easier to detect, their treatment is still controversial. Based on our experience with six patients and a review of the literature, we have tried to establish guidelines for their treatment. Since the...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01476418
更新日期:1994-01-01 00:00:00
abstract::We studied the influence of the type of surgery (microsurgery or macrosurgery) and extent (complete resection with lobectomy, complete resection alone, partial resection with lobectomy or partial resection alone) on early postoperative results and survival time in 118 consecutive patients who underwent surgery for gli...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01402111
更新日期:1991-01-01 00:00:00
abstract::A 28-year-old man with genetically confirmed hyperostosis corticalis generalisata (Van Buchem disease) suffered from headache and progressive cognitive and sensibility disorders. Bone formation of the skull was ongoing, leading to narrowing of the intracranial space and foramen magnum. A large bilateral frontoparietal...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-015-2445-1
更新日期:2015-07-01 00:00:00
abstract::Parafalcine chondrosarcoma is extremely rare, and may be difficult to differentiate preoperatively from falx meningioma. An 18-year-old woman presented with a parafalcine chondrosarcoma incidentally detected as a small lesion 2 years before admission, suggesting falx meningioma. Brain computed tomography and magnetic ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-005-0530-6
更新日期:2005-07-01 00:00:00
abstract:INTRODUCTION:Patients with thalamic hemorrhage, depressed level of consciousness and/or signs of elevated intracranial pressure may be treated with neurocritical care (NCC) and external ventricular drainage (EVD) for release of cerebrospinal fluid. METHODS:Forty-three patients with thalamic hemorrhage treated with NCC...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-013-1871-1
更新日期:2013-11-01 00:00:00
abstract::The characteristic findings of metrizamide CT cisternography in two cases of epidermoid are reported. The main finding was a "cauliflower-like" appearance and was thought to be caused by the irregular interstices of epidermoids. Metrizamide CT cisternography may be helpful in making a diagnosis of an epidermoid. ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400854
更新日期:1984-01-01 00:00:00
abstract::This experimental study presents the ultrastructure of regenerating sciatic nerve of the rabbit, after transection and immediate end to end anastomosis, using perineural fascicular nerve autograft, in a sterile environment. Twenty-four hours, 1, 2, and 6 weeks after the anastomosis, the treated sciatic nerves were exp...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01456115
更新日期:1987-01-01 00:00:00
abstract::A surgical carbon dioxide laser unit (laser) has been used since 1977 in twenty-five cases of various brain tumours, including ten meningiomas (four sphenoid ridge, two parasagittal, two falx, one olfactory, one posterior fossa), eleven gliomas (seven glioblastoma, four astrocytoma), two metastatic brain tumours, one ...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF02074786
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Computer-assisted design and manufacturing (CAD/CAM) techniques have been implemented in craniosynostosis surgery to facilitate cranial remodeling. However, until now, computed tomography (CT) scans with ionizing radiation were necessary to plan the procedure and create guiding templates. The purpose of this...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-020-04445-z
更新日期:2020-06-09 00:00:00
abstract::Intracranial meningiomas are characteristically benign tumours with a tendency to recur following surgical resection. Our group is investigating the pathogenesis of meningioma recurrence. In our initial studies we identified two cases of dural "tails" associated with intracranial meningiomas. Gadolinium-enhanced magne...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01401115
更新日期:1992-01-01 00:00:00
abstract::Cerebral primitive neuro-ectodermal tumour (PNET) occurring as a second primary malignancy in childhood is exceedingly rare. We present a 7-year-old boy who developed a proven supratentorial PNET five years after enucleation and radio-/chemotherapy for a sporadic, unilateral retinoblastoma with optic nerve invasion. T...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01420048
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Public engagement has become one of the most effective tools in gaining feedback and perspectives from members of the public, involving patients with decisions, and inspiring young people to carry the medical profession forwards. Brainbook is a multi-platform, social media-based resource that was created spe...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-018-3757-8
更新日期:2019-01-01 00:00:00
abstract::In 15 patients without acute brain injury the concentrations of Neuron-specific Enolase (NSE), S-100 Protein (S-100), Creatine Kinase (CK), and Creatine Kinase BB isoenzyme (CK-BB) in ventricular cerebrospinal fluid (CSF) were measured immediately after lateral ventricle cannulation for diagnostic or treatment purpose...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01400675
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Schwannomas occur sporadically or in association with neurofibromatosis 2 (NF2), an autosomal dominant disorder, which predisposes to multiple schwannomas, meningiomas and spinal ependymomas, with bilateral vestibular schwannomas as the classic hallmark. As NF2 and sporadic schwannomas differ in some respect...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s007010070036
更新日期:2000-01-01 00:00:00
abstract::Supervolt radiation therapy produced no improved survival rates in the treatment of glioblastoma multiforme as compared to orthovolt therapy. Survival times of more than one year or two years must still be considered a rarity. The application of computer techniques to the calculation of dose distributions greatly enha...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/BF01406633
更新日期:1978-01-01 00:00:00
abstract:BACKGROUND:Aneurysmal subarachnoid hemorrhage (SAH) causes long-term psychosocial impairments even in patients who regain functional independence. Little is known about predictors of these impairments. We studied how early clinical data and neuropsychological results predict work status and health-related quality of li...
journal_title:Acta neurochirurgica
pub_type: 杂志文章
doi:10.1007/s00701-012-1417-y
更新日期:2012-08-01 00:00:00