Characterization of cytokines present in pediatric otitis media with effusion: comparison of allergy positive and negative.

Abstract:

:To investigate the possible relationship between allergy and otitis media with effusion (OME), we investigated the cytokine level in the middle ear effusion (MEE)s of children with persistent OME. Interleukin (IL)-2, IL-4, IL-6 and tumor necrosis factor (TNF)-alpha in the MEEs were measured by devised sensitive sandwich enzyme-linked immunosorbent assay (ELISA) and compared allergy positive group with allergy negative group. The mean levels of IL-4, IL-6 and TNF-alpha in MEE were significantly higher in allergy positive group than allergy negative group (P<0.05). Elevation of Th-2-driven cytokines (IL-4, IL-6) and TNF-alpha in MEEs may be a contributing factor in the persistence of OME with allergy.

authors

Jang CH,Kim YH

doi

10.1016/s0165-5876(02)00185-4

subject

Has Abstract

pub_date

2002-10-21 00:00:00

pages

37-40

issue

1

eissn

0165-5876

issn

1872-8464

pii

S0165587602001854

journal_volume

66

pub_type

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