Elenoside, a new cytotoxic drug, with cardiac and extracardiac activity.

abstract：:Purslane (Portulaca oleracea L.) is popular as a potherb in many areas of Europe, Asia, and the Mediterranean region and is widely distributed around the globe. It has a wide range of pharmacological effects, such as antibacterial, anti-aging, anti-inflammatory, and anti-oxidative properties. Although the extract of p...

journal_title：Biological & pharmaceutical bulletin

authors： Kim JY,Oh HM,Kwak SC,Cheon YH,Lee MS,Rho MC,Oh J

更新日期：2015-01-01 00:00:00

abstract：:The first-pass intestinal metabolism of 5-fluorouracil (5-FU) was investigated by single-pass perfusion of the rat small intestine. At the low concentration of 0.06 mg/ml, the fraction of 5-FU absorbed into (i.e., appeared in) the mesenteric venous blood (Fa,b) was about 50% smaller than the fraction absorbed (disappe...

journal_title：Biological & pharmaceutical bulletin

authors： Gu J,Yuasa H,Hayashi Y,Watanabe J

更新日期：1998-08-01 00:00:00

abstract：:The therapeutic value of an antirheumatic alkaloid, sinomenine (SIN), was investigated in the acute experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). SIN is a bioactive alkaloid derived from the Chinese medicinal plant, Sinomenium acutum REHDER & E. H. WILSON (Family Menispermaceae). Ch...

journal_title：Biological & pharmaceutical bulletin

authors： Zeng Y,Gu B,Ji X,Ding X,Song C,Wu F

更新日期：2007-08-01 00:00:00

abstract：:Schwann cell injury is observed in diabetic neuropathy. It is speculated that glycolaldehyde (GA), a precursor of advanced glycation end products (AGEs), contributes to the pathogenesis and development of diabetic neuropathy. Here, we demonstrated for the first time that GA at near-physiological concentration decrease...

journal_title：Biological & pharmaceutical bulletin

authors： Sato K,Tatsunami R,Yama K,Tampo Y

更新日期：2013-01-01 00:00:00

abstract：:We have recently demonstrated that Bak Foong Pills (BFP), a well-known Chinese medicine widely used for treating gynecological disorders, stimulates human colonic epithelial anion secretion, which was mediated by intracellular cAMP and Ca(2+). The present study further investigated the effect of BFP on exocrine pancre...

journal_title：Biological & pharmaceutical bulletin

authors： Tang N,Zhu JX,Zhao WC,Xing Y,Gou YL,Rowlands DK,Chung YW,Chan HC

更新日期：2003-10-01 00:00:00

abstract：:The oligopeptide transporter PEPT1 (SLC15A1) is responsible for absorption of peptidic nutrients in the small intestine. Although the L-diastereomer of the beta-lactam antibiotic cephalexin (L-cephalexin) is likely to be transported by PEPT1, there has been no direct demonstration of PEPT1-mediated L-cephalexin transp...

journal_title：Biological & pharmaceutical bulletin

authors： Mitsuoka K,Tamai I,Morohashi Y,Kubo Y,Saitoh R,Tsuji A,Kato Y

更新日期：2009-08-01 00:00:00

abstract：:The objectives of the present study were to assess pharmacokinetics, pharmacodynamics, tolerability and safety of intravenous administration of bivalirudin, a direct thrombin inhibitor, in healthy Chinese subjects. 48 subjects were equally divided into 4 groups (0.5 mg/kg, 0.75 mg/kg, 1.05 mg/kg intravenous bolus, and...

journal_title：Biological & pharmaceutical bulletin

authors： Zhang D,Wang Z,Zhao X,Lu W,Gu J,Cui Y

更新日期：2011-01-01 00:00:00

abstract：:Ceramide kinase (CerK) and ceramide-1-phosphate (C1P) are involved in various cellular functions, while regulation of the enzyme activity has not been well elucidated. We herein investigated the effects of several glycerophospholipids on human recombinant CerK activity with CaCl2 and MgCl2 by measuring the formation o...

journal_title：Biological & pharmaceutical bulletin

authors： Matsuzaki W,Takahashi H,Nakamura H,Murayama T

更新日期：2016-01-01 00:00:00

abstract：:The effect of fungichromin (FC) on the formation of Candida albicans biofilm was assessed using 2,3-bis(2-methoxy-4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction method, scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). Results showed that FC revealed an inhibitor...

journal_title：Biological & pharmaceutical bulletin

authors： An D,Wang X,Li J,Jiang S,Ma X,Zhang H,Shi H,Sun H,Ye L,Li J

更新日期：2016-12-01 00:00:00

abstract：:In vitro studies were conducted to identify human drug-metabolizing enzymes involved in the metabolism of SNI-2011 ((+/-)-cis-2-methylspiro [1,3-oxathiolane-5,3'-quinuclidine] monohydrochloride hemihydrate, cevimeline hydrochloride hydrate). When 14C-SNI-2011 was incubated with human liver microsomes, SNI-2011 trans-s...

journal_title：Biological & pharmaceutical bulletin

authors： Washio T,Arisawa H,Kohsaka K,Yasuda H

更新日期：2001-11-01 00:00:00

abstract：:The effects of Ginkgo biloba leaf extract (GBE), one of the most widely used herbal dietary supplements in Japan and the United States, on the pharmacokinetics of nifedipine (NFP), a typical probe of P450 (CYP) 3A, but not a substrate of the multidrug transporter P-glycoprotein (P-gp), were studied using rats. Simulta...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshioka M,Ohnishi N,Sone N,Egami S,Takara K,Yokoyama T,Kuroda K

更新日期：2004-12-01 00:00:00

abstract：:We previously reported the isolation of a novel cerebroside (1-O-(beta-D-glucopyranosyl)-(2S,3R,4E,8Z)-2-N-palmityloc tadecasphinga-4,8-diene; LCC) from the fruits of Lycium chinense MILL. (Solanaceae) which protected primary cultured rat hepatocytes from the toxicity induced by carbon tetrachloride (CCl4). The presen...

journal_title：Biological & pharmaceutical bulletin

authors： Kim SY,Lee EJ,Kim HP,Kim YC,Moon A,Kim YC

更新日期：1999-08-01 00:00:00

abstract：:The possibility of pharmacokinetic interactions between Sho-saiko-to extract powder (TJ-9), the most widely used traditional Chinese herbal (Kampo) medicine in Japan, and carbamazepine (CBZ), an important anti-epileptic drug, was examined in rats. There was no significant difference in the protein binding of CBZ in se...

journal_title：Biological & pharmaceutical bulletin

authors： Ohnishi N,Okada K,Yoshioka M,Kuroda K,Nagasawa K,Takara K,Yokoyama T

更新日期：2002-11-01 00:00:00

abstract：:A protein was purified from rabbit seminal plasma using preparative acrylamide disc electrophoresis, ammonium sulfate precipitation and gel filtration. The protein inhibited the in vitro fertilization of mouse ova inseminated with epididymal sperm and with capacitated sperm. The inhibition was not observed, however, w...

journal_title：Biological & pharmaceutical bulletin

authors： Okabe M,Kishi Y,Ying X,Kohama Y,Mimura T,Li SS

更新日期：1993-05-01 00:00:00

abstract：:The effect of carboxamidemethylated Fc fragment (CM-Fc) from human immunoglobulin G (IgG) on type II collagen (C II)-induced arthritis (CIA) in DBA/1J mice was studied. CM-Fc suppressed the development of CIA while Fc fragment did not. CM-Fc inhibited the increase in serum anti-C II IgG. CM-Fc suppressed C II-induced ...

journal_title：Biological & pharmaceutical bulletin

authors： Mimura T,Itoh M,Gohgi H,Suzuki N,Takeuchi K,Tsujikawa K,Kohama Y

更新日期：1994-05-01 00:00:00

abstract：:It is known that female rats are resistant to ischemic acute renal failure (ARF), compared with male rats. To elucidate sex differences in ischemic ARF, we searched global protein expression in post-ischemic kidneys using proteomic techniques. Ischemic ARF was induced by 45-min ischemia followed by reperfusion. By pro...

journal_title：Biological & pharmaceutical bulletin

authors： Takayama J,Takaoka M,Sugino Y,Yamamoto Y,Ohkita M,Matsumura Y

更新日期：2007-10-01 00:00:00

abstract：:The fundamental role that receptor tyrosine kinases play in cancer and other proliferative diseases has provided the impetus for an extensive effort on the part of both academic and pharmaceutical laboratories to develop highly specific inhibitors. In this study, inhibitory activity of previously synthesized arylaceti...

journal_title：Biological & pharmaceutical bulletin

authors： Altuntas TG,Olgen S,Nebioglu D,Akaho E

更新日期：2004-01-01 00:00:00

abstract：:This study was designed to evaluate the protective effect of kolaviron (KV), a biflavonoid from Garcinia kola seeds, against gamma-radiation (5 Gy)-induced oxidative stress in brain of Wistar rats. Vitamin C (VC) served as standard antioxidant. Forty-four rats were divided into 4 groups of 11 animals each. One group w...

journal_title：Biological & pharmaceutical bulletin

authors： Adaramoye OA

更新日期：2010-01-01 00:00:00

abstract：:Cynanchi Wilfordii Radix (CWR) is used in Korea as a substitute for Polygoni Multiflori Radix (PMR), which is a crude drug traditionally used in East Asian countries. Recently, the use of Cynanchi Auriculati Radix (CAR) in place of PMR and CWR has emerged a major concern in the Korean market. In Japan, PMR is permitte...

journal_title：Biological & pharmaceutical bulletin

authors： Sato-Masumoto N,Uchikura T,Sugiwaki H,Yoshimura M,Masada S,Atsumi T,Watanabe M,Tanaka N,Uchiyama N,Amakura Y,Hakamatsuka T

更新日期：2017-01-01 00:00:00

abstract：:Extract from fruits of Nandina domestica THUNBERG (NDE) has been used to improve cough and breathing difficulty in Japan for many years. To explore whether NDE may alleviate respiratory inflammation, we investigated its effect on expression of cyclooxygenase-2 (COX-2) and production of prostaglandin E₂ (PGE₂) in human...

journal_title：Biological & pharmaceutical bulletin

authors： Ueki T,Akaishi T,Okumura H,Abe K

更新日期：2012-01-01 00:00:00

abstract：:DNA rich in non-methylated CG motifs (CpGs) enhances induction of immune responses against co-administered antigen encoding genes. CpGs are therefore among the promising adjuvants known to date. However, naked plasmid DNA, even which contains CpG motifs, are taken up by antigen presenting cells via the endocytosis pat...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshikawa T,Imazu S,Gao JQ,Hayashi K,Tsuda Y,Okada N,Tsutsumi Y,Akashi M,Mayumi T,Nakagawa S

更新日期：2006-01-01 00:00:00

abstract：:The cardiac toxicity of amitriptyline and the effect of the light schedule on it were studied in chick embryos. Fertilized eggs of White Leghorns were incubated under dark conditions and investigated, on two occasions, in the light phase and in the dark phase. Amitriptyline was injected into the air sac of fertilized ...

journal_title：Biological & pharmaceutical bulletin

authors： Yoshiyama Y,Sugiyama T,Kanke M

更新日期：2004-02-01 00:00:00

abstract：:A hydroalcoholic (50%) extract of Emblica officinalis (fruit) (EO-50) reduced the severity of hepatic fibrosis induced by carbon tetrachloride (CCl4) and thioacetamide (TAA). Improved liver function was observed by measuring the levels of aspartate aminotransaminase (AST), alanine aminotransferase (ALT), alkaline phos...

journal_title：Biological & pharmaceutical bulletin

authors： Tasduq SA,Mondhe DM,Gupta DK,Baleshwar M,Johri RK

更新日期：2005-07-01 00:00:00

abstract：:We investigated the cytotoxicity of eight vitamin K3 (VK3) analogs against neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, and SK-N-SH) and normal cell lines (human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)) using a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) a...

journal_title：Biological & pharmaceutical bulletin

authors： Kitano T,Yoda H,Tabata K,Miura M,Toriyama M,Motohashi S,Suzuki T

更新日期：2012-01-01 00:00:00

abstract：:The predictability of serum vancomycin (VCM) concentrations by means of the Bayesian method was evaluated to establish whether the method can be used to select safe and effective VCM treatment regimens for individual patients. Serum VCM concentrations at the trough and 2 h after the end of infusion (peak) were measure...

journal_title：Biological & pharmaceutical bulletin

authors： Teramachi H,Hatakeyama H,Matsushita R,Imai Y,Miyamoto K,Tsuji A

更新日期：2002-10-01 00:00:00

abstract：:The present study was to study the hepatoprotective effects of phloridzin (PHL) on hepatic fibrosis induced by carbon tetrachloride (CCl₄) in rats, on the basis of this investigation, the possible mechanism of PHL was elucidated. Male Sprague Dawley (SD) rats were randomly divided into six groups: control, model, PHL-...

journal_title：Biological & pharmaceutical bulletin

authors： Deng G,Wang J,Zhang Q,He H,Wu F,Feng T,Zhou J,Zou K,Hattori M

更新日期：2012-01-01 00:00:00

abstract：:Seventeen thiopaeonimetabolin-I adducts were obtained as mixtures of diastereoisomers after incubation of paeoniflorin with Lactobacillus brevis in the presence of various thiols. The anticonvulsant activity of the adducts was investigated in mice using the maximal subcutaneous pentylenetetrazol seizure test and sodiu...

journal_title：Biological & pharmaceutical bulletin

authors： Abdel-Hafez AA,Meselhy MR,Nakamura N,Hattori M,Watanabe H,Murakami Y,El-Gendy MA,Mahfouz NM,Mohamed TA

更新日期：1999-05-01 00:00:00

abstract：:Fibroin, the protein of silk, and hydrolyzed fibroin have recently been described to enhance insulin sensitivity and glucose metabolism in 3T3-L1 adipocytes. Here, we report that a series of synthetic peptides derived from the fibroin sequence have enhancing effects on glucose transport in normal and insulin-resistant...

journal_title：Biological & pharmaceutical bulletin

authors： Kim ED,Bayaraa T,Shin EJ,Hyun CK

更新日期：2009-03-01 00:00:00

abstract：:P2X7 receptor (P2X7R), a purinergic receptor, is involved in pathophysiological events such as inflammation and cell death, and thus is an attractive target for therapeutic approaches. It is reported that divalent metal cations (DMCs) inhibit P2X7R activation and that there are species differences in their inhibitory ...

journal_title：Biological & pharmaceutical bulletin

authors： Fujiwara M,Ohbori K,Ohishi A,Nishida K,Uozumi Y,Nagasawa K

更新日期：2017-01-01 00:00:00

abstract：:Nine compounds, including six phenylethanoid glycosides: acteoside (1); bioside (2); echinacoside (3); poliumoside (4); phenylethyl glycoside (5); salidroside (6) and three flavonoids; linarin (7); apigenin (8); isorhoifolin (9), were isolated from the flowers of Buddleja officinalis MAXIM. (Buddlejaceae). Chemical st...

journal_title：Biological & pharmaceutical bulletin

authors： Tai BH,Jung BY,Cuong NM,Linh PT,Tung NH,Nhiem NX,Huong TT,Anh NT,Kim JA,Kim SK,Kim YH

更新日期：2009-12-01 00:00:00