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Cytotoxic T lymphocyte epitope analogues containing cis- or trans-4-aminocyclohexanecarboxylic acid residues.

Abstract：

:In order to improve the immunotherapeutical potential of H-Cys-Leu-Gly-Gly-Leu-Leu-Thr-Met-Val-OH (CLG) peptide, an Epstein-Barr virus (EBV) subdominant epitope derived from the membrane protein LMP2, we have synthesized and tested CLG analogues containing cis- and/or trans-4-aminocyclohexanecarboxylic acid (ACCA) replacing Gly-Gly and/or Thr-Met dipeptide units. All pseudopeptides were tested for metabolic stability and for their capacity to bind HLA-A2 molecules and to sensitize target cells to lysis. All new compounds exhibited higher enzymatic resistance compared to the original CLG and some trans-ACCA-derivatives were able to associate HLA-A2 and to efficiently stimulate CTL responses directed against the CLG natural epitope.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Marastoni M,Bazzaro M,Micheletti F,Gavioli R,Tomatis R

doi

10.1016/s0968-0896(02)00033-0

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

3061-6

issue

9

eissn

0968-0896

issn

1464-3391

pii

S0968089602000330

journal_volume

10

pub_type

杂志文章

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