Abstract：
:The development of functions for MATLAB and S-PLUS that can be used for the evaluation of specific population pharmacokinetic designs has been described recently. These functions are based on the evaluation of an approximation of the population Fisher information matrix. Optimisation of the design of the population experiment can be made on the basis of D-optimal design techniques, where the determinant of the population Fisher information matrix is maximised. This maximisation is complex due to the convoluted nature of the surface of the determinant. Four optimisation algorithms (simplex, non-adaptive random search, non-adaptive random search followed by simplex and simulated annealing) are compared in their ability to optimise the sampling times for various design structures for three examples of population pharmacokinetic models. In all cases, despite more computing time, simulated annealing was superior to the other methods for finding optimal designs with greater benefits being seen over the other algorithms for the more complex designs.
journal_name
Comput Methods Programs Biomedjournal_title
Computer methods and programs in biomedicineauthors
Duffull SB,Retout S,Mentré Fdoi
10.1016/s0169-2607(01)00178-xsubject
Has Abstractpub_date
2002-07-01 00:00:00pages
25-35issue
1eissn
0169-2607issn
1872-7565pii
S016926070100178Xjournal_volume
69pub_type
杂志文章abstract：BACKGROUND AND OBJECTIVE:Diabetic disease is typically composed because of higher than normal blood sugar levels. Instead the production of insulin may be regarded insufficient. It has been noted in recent days that the percentage of diabetes-affected patients have grown to a larger extent throughout the world. Evident...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105659
更新日期：2020-11-01 00:00:00
abstract：:This paper discusses the underlying issues in the evaluation of computer systems which apply artificial intelligence in medicine. Three different levels of evaluation are described: the subjective evaluation of the research contribution of a developmental prototype, the validation of a system's knowledge and performan...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：
更新日期：1986-03-01 00:00:00
abstract：:Magnetic resonance angiography (MRA) offers a non-invasive approach to the acquisition of anatomically accurate human arterial structure. Combining the latest computational fluid dynamics (CFD) techniques with clinical data from MRA, the detailed haemodynamics information in the human circulation system can be obtaine...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(98)00008-x
更新日期：1998-06-01 00:00:00
abstract：:A method to determine the shapes of a thermally fluctuating phospholipid vesicle is described. The vesicle that was attached at one point to a glass plate was submitted to a flow. It was observed by an inverted optical microscope using phase contrast technique. A large number of consecutive video images were digitised...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/S0169-2607(03)00065-8
更新日期：2004-03-01 00:00:00
abstract：:Open hashing is used to demonstrate the effectiveness of several hashing functions for the uniform distribution of biological records. The three types of database tested include (1) genetic nomenclature, mutation sites and strain names, (2) surnames extracted from literature files and (3) a set of 1000 numeric ASCII s...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(89)90164-8
更新日期：1989-02-01 00:00:00
abstract：:Several approaches, based on different assumptions and with various degree of theoretical sophistication and implementation complexity, have been developed for improving the measurement of evoked potentials (EP) performed by conventional averaging (CA). In many of these methods, one of the major challenges is the expl...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(01)00175-4
更新日期：2002-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The application of medical knowledge strongly affects the performance of intelligent diagnosis, and method of learning the weights of medical knowledge plays a substantial role in probabilistic graphical models (PGMs). The purpose of this study is to investigate a discriminative weight-learning...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.01.005
更新日期：2018-03-01 00:00:00
abstract：:Following the paper publication of practice guidelines for the management of febrile patients returning from the tropics, we constructed a consultation website that comprises a decision chart and specific diagnostic features providing medical diagnostic assistance to primary care physicians. We then integrated a resea...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2006.09.004
更新日期：2007-01-01 00:00:00
abstract：:This work provides a performance comparison of four different machine learning classifiers: multinomial logistic regression with ridge estimators (MLR) classifier, k-nearest neighbours (KNN), support vector machine (SVM) and naïve Bayes (NB) as applied to terahertz (THz) transient time domain sequences associated with...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2016.01.017
更新日期：2016-04-01 00:00:00
abstract：:A parametric model for the ultrasound signals from blood and tissue is developed and a new imaging method, knowledge-based imaging, is defined. This method utilizes the likelihood ratio function to classify blood and tissue signals. The method separates blood and tissue signals by the difference in movement patterns i...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2009.03.012
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Congenital anomalies are seen at 1-3% of the population, probabilities of which are tried to be found out primarily through double, triple and quad tests during pregnancy. Also, ultrasonographical evaluations of fetuses enhance detecting and defining these abnormalities. About 60-70% of the ano...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.06.010
更新日期：2018-09-01 00:00:00
abstract：:Steady state flux balance analysis (FBA) for cellular metabolism is used, e.g., to seek information on the activity of the different pathways under equilibrium conditions, or as a basis for kinetic models. In metabolic models, the stoichiometry of the system, commonly completed with bounds on some of the variables, is...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2009.07.007
更新日期：2010-02-01 00:00:00
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journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(01)00132-8
更新日期：2001-07-01 00:00:00
abstract：:This study employs the concept of applying constant-phase models to input respiratory impedance data obtained with the non-invasive Forced Oscillation Technique (FOT) lung function test. Changes in respiratory mechanics from healthy and chronic obstructive pulmonary disease (COPD) diagnosed patients are observed with ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2009.06.006
更新日期：2010-01-01 00:00:00
abstract：:A computer program for a microcomputer (HP 86) is presented to discriminate between different models and to design new experiments for model discrimination. By a non-linear fitting algorithm a set of experimental data is fitted with different models suggested by the user. The parameters characterizing each model are e...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(86)90022-2
更新日期：1986-04-01 00:00:00
abstract：:Role of hepatic insulin degradation in modulating insulin delivery to peripheral circulation, in insulin-resistant hypertensive patients, is not yet fully understood. This issue was investigated here by a novel application to hypertension of a previously proposed minimal modelling of insulin and C-peptide data, using ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2009.08.007
更新日期：2010-02-01 00:00:00
abstract：:Interventricular septum thickness in end-diastole (IVSd) is one of the key parameters in cardiology. This paper presents a fast algorithm, suitable for pocket-sized ultrasound devices, for measurement of IVSd using 2D B-mode parasternal long axis images. The algorithm is based on a deformable model of the septum and t...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2011.02.011
更新日期：2012-11-01 00:00:00
abstract：:A confocal microscope can produce gray-scale images of the different layers of the cornea. We have addressed the problem of classifying these images, i.e. recognizing the layer displayed, using the shape of the cells contained, which is uniquely related to each specific layer. A first method was designed, based first ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/s0169-2607(01)00153-5
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Early detection of cardiovascular (CV) disease or associated risk factors during childhood is of paramount importance, allowing for early treatment or lifestyle modifications, respectively. The objective of this study was to describe the development of an electronic health record (EHR), with in...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.03.009
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Finite element based simulation has emerged as a powerful tool to analyse the tooth strength and its fracture characteristics. The aim of this study is to compare and evaluate the fracture resistance of immature teeth reinforcement with MTA, Biodentine and Bioaggregate as an apical plug and bac...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2020.105356
更新日期：2020-07-01 00:00:00
abstract：:We have developed a fast, user friendly, ray-tracing program, "CSIM" for low-energy gamma rays (up to ∼200keV) to simulate the performance characteristics of parallelhole collimators. We have used a ray-tracing approach to find the sensitivity and resolution of the parallelhole collimator by including the penetration ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2012.12.004
更新日期：2013-06-01 00:00:00
abstract：:The identification of thousands of mutations yearly has put new challenges to researchers who are interested in fast and effective annotation as well as the prediction of potential implications to the gene regulation mechanisms. This work presents an integrative tool, called GREMET, for the prediction of alterations i...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.04.002
更新日期：2013-07-01 00:00:00
abstract：:This article presents a method of predictive simulation, patient-dependant, in real time of the abdominal organ positions during free breathing. The method, that considers both influence of the abdominal breathing and thoracic breathing, needs a tracking of the patient skin and a model of the patient-specific modifica...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2010.03.003
更新日期：2010-11-01 00:00:00
abstract：:In this paper we discuss the SIMID tool for simulation of the spread of infectious disease, enabling spatio-temporal visualization of the dynamics of influenza outbreaks. SIMID is based on modern random network methodology and implemented within the R and GIS frameworks. The key advantage of SIMID is that it allows no...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.01.007
更新日期：2013-06-01 00:00:00
abstract：:Tight glycemic control (TGC) has shown benefits in ICU patients, but been difficult to achieve consistently due to inter- and intra- patient variability that requires more adaptive, patient-specific solutions. STAR (Stochastic TARgeted) is a flexible model-based TGC framework accounting for patient variability with a ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2011.07.003
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVE:This paper proposes a novel approach for automatic left ventricle (LV) quantification using convolutional neural networks (CNN). METHODS:The general framework consists of one CNN for detecting the LV, and another for tissue classification. Also, three new deep learning architectures were proposed for LV quan...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2018.12.002
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Heart rate variability (HRV) has increasingly been linked to medical phenomena and several HRV metrics have been found to be good indicators of patient health. This has enabled generalised treatment plans to be developed in order to respond to subtle personal differences that are reflected in ...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2019.105127
更新日期：2020-03-01 00:00:00
abstract：:The increasing flow of short time series microarray experiments for the study of dynamic cellular processes poses the need for efficient clustering tools. These tools must deal with three primary issues: first, to consider the multi-functionality of genes; second, to evaluate the similarity of the relative change of a...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2013.05.025
更新日期：2013-09-01 00:00:00
abstract：:A linear time invariant model is applied to functional fMRI blood flow data. Based on traditional time series analysis, this model assumes that the fMRI stochastic output sequence can be determined by a constant plus a linear filter (hemodynamic response function) of several fixed deterministic inputs and an error ter...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/j.cmpb.2005.12.003
更新日期：2006-04-01 00:00:00
abstract：:ENDO-LAB is an IBM PC-based system which performs calculations and record-keeping for the Vanderbilt University Medical Center Endocrinology Laboratory. It manages maintenance and quality control, and prints reports for regulatory agencies. The system was designed to minimize paperwork without changing laboratory proc...
journal_title：Computer methods and programs in biomedicine
pub_type： 杂志文章
doi：10.1016/0169-2607(88)90088-0
更新日期：1988-11-01 00:00:00
