Abstract:
:Single nucleotide polymorphisms (SNPs) are about to become one of the most popular genetic markers for genetic model organisms. To test the usefulness of SNPs for estimating genetic diversity, we surveyed three genomic regions in two Drosophila melanogaster populations, one from Africa and one European, collected in Austria. Diversity estimates based on the full SNP set indicated higher levels of variability in the African than in the European flies. When the analysis was based on the European SNP set, European and African flies had similar levels of variability. Interestingly, this bias was not observed for diversity estimates using SNPs derived from the ancestral African population. This result suggests that diversity estimates based on SNPs from ancestral populations could provide a general strategy to avoid biased SNP diversity estimates. Finally, the potential of SNPs for nonmodel organisms is discussed.
journal_name
Mol Ecoljournal_title
Molecular ecologyauthors
Schlötterer C,Harr Bdoi
10.1046/j.1365-294x.2002.01491.xsubject
Has Abstractpub_date
2002-05-01 00:00:00pages
947-50issue
5eissn
0962-1083issn
1365-294Xpii
1491journal_volume
11pub_type
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