Abstract:
:Large scale gene perturbation experiments generate information about the number of genes whose activity is directly or indirectly affected by a gene perturbation. From this information, one can numerically estimate coarse structural network features such as the total number of direct regulatory interactions and the number of isolated subnetworks in a transcriptional regulation network. Applied to the results of a large-scale gene knockout experiment in the yeast Saccharomyces cerevisiae, the results suggest that the yeast transcriptional regulatory network is very sparse, containing no more direct regulatory interactions than genes. The network comprises >100 independent subnetworks.
journal_name
Genome Resjournal_title
Genome researchauthors
Wagner Adoi
10.1101/gr.193902subject
Has Abstractpub_date
2002-02-01 00:00:00pages
309-15issue
2eissn
1088-9051issn
1549-5469journal_volume
12pub_type
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