Abstract：
:We previously showed that the intracerebroventricular injection of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) released adrenocorticotropic hormone (ACTH) and upregulated transcripts for corticotropin-releasing factor (CRF) and vasopressin in the paraventricular nucleus (PVN) of the rat hypothalamus. In the present work, we microinfused SIN-1 into the PVN itself, the amygdala, the hippocampus or the frontal cortex to identify the brain regions that modulate the influence of NO on the hypothalamic-pituitary-adrenal (HPA) axis. Microinfusion into the PVN, which contains most of the CRF and vasopressin neurones that control HPA axis activity, significantly released ACTH. Microinfusion into the amygdala or the hippocampus, areas which also regulate HPA axis activity, similarly increased plasma ACTH levels. However, these responses were smaller and showed a delayed onset, compared to that observed following PVN treatment. In contrast, microinfusion of SIN-1 into the frontal cortex, which is not believed to exert a major direct influence on the HPA axis, was without effect. The observation that compared to microinfusion into the PVN, peak ACTH levels were both smaller and delayed when SIN-1 was microinfused into the amygdala or the hippocampus, and that SIN-1 only increased NO levels when injected into the PVN, suggests that the NO donor injected outside the PVN activates this nucleus by targeting pathways that connect it to these other regions rather than by leakage. Collectively, our results provide important clues regarding the putative role of these regions in modulating the influence of NO on the HPA axis.
journal_name
J Neuroendocrinoljournal_title
Journal of neuroendocrinologyauthors
Seo DO,Rivier Cdoi
10.1046/j.1365-2826.2001.00690.xsubject
Has Abstractpub_date
2001-11-01 00:00:00pages
925-33issue
11eissn
0953-8194issn
1365-2826pii
690journal_volume
13pub_type
杂志文章abstract：:Neurons from hypothalamic paraventricular nuclei (PVN) and supraoptic nuclei (SON) from postnatal day 6-8 rats were enzymatically dissociated and separately maintained in monolayer cultures for 14 days. The osmotic pressure of the culture medium, based on Neurobasal medium (Life Technologies), was varied (255, 300 and...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1999.00296.x
更新日期：1999-02-01 00:00:00
abstract：:Abstract The effect of intraperitoneally administered gamma-hydroxybutyrate on the hypothalamo-hypophysial-adrenocortical axis was studied. A significant increase in plasma corticosterone was induced by the administration of gamma-hydroxybutyrate (100 mg/kg). The lack of antagonism of this action of gamma-hydroxybutyr...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1990.tb00439.x
更新日期：1990-08-01 00:00:00
abstract：:The aim of the present study was to analyse whether hormonal responses could explain an exercise limitation in Down's syndrome (DS). Fourteen young men with DS (mean age 22.5 +/- 0.7 years) and 15 controls (CONT, mean age 22.5 +/- 0.3 years) participated in the study. During a treadmill submaximal incremental test, bl...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2008.01695.x
更新日期：2008-05-01 00:00:00
abstract：:We studied the effect of corticosterone on interleukin (IL)-1 beta synthesis, body temperature, general activity, food consumption and fluid intake in rats treated with bacterial lipopolysaccharide (LPS). Radiotelemetry was used to assess body temperature and locomotor activity in combination with continuous automated...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1996.tb00833.x
更新日期：1996-02-01 00:00:00
abstract：:NADPH-diaphorase has recently been shown to be the enzyme nitric oxide (NO) synthase, and to be present in the rat supraoptic nucleus (SON) and posterior pituitary. Investigations were carried out to assess whether there is any difference in the extent to which this enzyme is present, as assessed by light-microscopic ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1992.tb00183.x
更新日期：1992-08-01 00:00:00
abstract：:Seasonal animals use different strategies to reduce energy expenditure in the face of reduced seasonal food availability. For example, the ground squirrel enters a hibernation state with reduced metabolism, hypothermia and suppressed central nervous system activity, whereas the Djungarian hamster (Phodopus sungorus) e...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2007.01620.x
更新日期：2007-12-01 00:00:00
abstract：:This study examined the immunolocalization and ontogeny of the inhibin-specific alpha subunit in the brain of male rats. Immunohistochemistry using antiserum directed against the mature region of porcine inhibin alpha (1-19, Tyr20) revealed positive reactions in process-bearing cells resembling astroglia in several re...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1999.00310.x
更新日期：1999-03-01 00:00:00
abstract：:The spatial and temporal expression of steroidogenic genes in zebrafish has not been fully characterised. Because zebrafish are increasingly employed in endocrine and stress research, a better characterisation of steroidogenic pathways is required to target specific steps in the biosynthetic pathways. In the present s...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12586
更新日期：2018-04-01 00:00:00
abstract：:Rat pituitary homogenates were submitted to differential and density gradient centrifugation. Subcellular fractions as well as the purified secretory granules were examined in electron microscopy, radioimmunological techniques, protease digestion, alkaline treatment and immunoblotting. The global outcome of these expe...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1993.tb00538.x
更新日期：1993-12-01 00:00:00
abstract：:It is well-known that alpha-melanophore-stimulating hormone (alpha-MSH) release from the amphibian pars intermedia (PI) depends on the light condition of the animal's background, permitting the animal to adapt the colour of its skin to background light intensity. In the present study, we carried out nine experiments o...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2004.01247.x
更新日期：2004-11-01 00:00:00
abstract：:Many animals synchronise their reproductive activity with the seasons to optimise the survival of their offspring. This synchronisation involves switching on and off their gonadotrophic axis. Ever since their discovery as key regulators of gonadotrophin-releasing hormone (GnRH) neurones, the hypothalamic RF-amide pept...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12529
更新日期：2017-09-01 00:00:00
abstract：:Maternal neglect, including physical and emotional neglect, is a pervasive public health challenge with serious long-term effects on child health and development. I provide an overview of the neurobiological basis of maternal caregiving, aiming to better understand how to prevent and respond to maternal neglect. Drawi...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2826.2011.02228.x
更新日期：2011-11-01 00:00:00
abstract：:Intravenous infusion of hypertonic saline increased plasma [Na (+) ] and osmolality and induced a short-latency drinking response. These changes were associated with increased glucose utilization in the supraoptic and paraventricular nuclei and neural lobe, and decreases in the medial septum and nucleus ambiguus. The ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1992.tb00162.x
更新日期：1992-04-01 00:00:00
abstract：:During development, melatonin receptors are transiently expressed in multiple neuroendocrine tissues, suggesting a novel role for melatonin in developmental physiology. The best characterised model of melatonin signalling during development is the pars distalis of the rat pituitary. However, although many studies have...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2005.01389.x
更新日期：2006-01-01 00:00:00
abstract：:Ovulation in vertebrates is caused by a surge of luteinising hormone (LH) from the pituitary. The LH surge is initiated by rising oestradiol concentration, although the precise mechanism of oestradiol action in humans and primates is not yet understood. Recent advances in labelling and three-dimensional imaging have r...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2010.02084.x
更新日期：2010-12-01 00:00:00
abstract：:Siberian hamsters (Phodopus sungorus) rely on photoperiod as a primary cue to coordinate seasonally appropriate changes in physiology and behaviour. Among these seasonal changes is reduced immune function in short 'winter-like' days, compared to long 'summer-like' days. Previous evidence suggests that immune function ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.0007-1331.2001.00736.x
更新日期：2002-01-01 00:00:00
abstract：:The novel apelin receptor (APJ receptor, APJR) has a restricted expression in the central nervous system suggestive of an involvement in the regulation of body fluid homeostasis. The endogenous ligand for APJR, apelin, is also highly concentrated in regions that are involved in the control of drinking behaviour. While...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2003.01044.x
更新日期：2003-07-01 00:00:00
abstract：:Prairie voles (Microtus ochrogaster) are monogamous mammals that form male-female pair bonds. Partner preference formation, one component of the pair bond in prairie voles, occurs following male-female cohabitation and is facilitated by mating. The peptide hormone oxytocin is released during physical contact and parti...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1994.tb00579.x
更新日期：1994-06-01 00:00:00
abstract：:Opioid effects on synaptic transmission in the mouse supraoptic nucleus (SON) were investigated using whole-cell, patch-clamp techniques. The mu-opioid receptor agonist, [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin (DAMGO) decreased the amplitude of both evoked excitatory postsynaptic currents (eEPSCs) and inhibitory...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.0953-8194.2004.01151.x
更新日期：2004-03-01 00:00:00
abstract：:Psychiatric patients suffering from anxiety disorders or endogenous depression exhibit increased activity in their hypothalamo-pituitary-adrenocortical (HPA) axis. Recently, two Wistar rat lines, bred for high (HAB) and low (LAB) anxiety-related behaviour on the elevated plus-maze, were described as a unique psychopat...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1999.00342.x
更新日期：1999-06-01 00:00:00
abstract：:Neuropeptide Y (NPY) is found in autonomic neurones and participates in regulation of autonomic functions. To investigate the role of NPY in the stress response in normo- and hypertensive rats, activation of brainstem and arcuate nucleus (ARC) NPY neurones and levels of NPY mRNA in the ARC were measured in response to...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.1999.00391.x
更新日期：1999-09-01 00:00:00
abstract：:Interleukin (IL)-6 has been involved in the control of body weight and body fat. Nevertheless, the mechanisms underlying these effects are not completely understood because central and peripheral actions of IL-6 are plausible. To gain further insight into the central effects of IL-6, we used transgenic mice expressing...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2011.02158.x
更新日期：2011-08-01 00:00:00
abstract：:Stress exposure during early-life development can programme individual brain and physiology. The hypothalamic-pituitary-adrenal (HPA) axis is one of the primary targets of this programming, which is generally associated with a hyperactive HPA axis, indicative of a reduced negative-feedback. This reduced feedback effic...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/jne.12228
更新日期：2014-12-01 00:00:00
abstract：:Oxytocin and vasopressin reduce the amplitude of excitatory postsynaptic responses in magnocellular neuroendocrine cells of the supraoptic nucleus (SON). To test whether synaptic glutamate release is modulated by these neuropeptides, we examined the combined effect of vasopressin and oxytocin on depolarization-induced...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2003.00976.x
更新日期：2003-02-01 00:00:00
abstract：:Individual variation in the expression of maternal behaviour can affect offspring development and survival. Ewes showing a poorer quality of maternal behaviour (low levels of licking and grooming, infrequent low-pitched bleating, inconsistent udder acceptance) at parturition and throughout lactation (large ewe-lamb di...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2826.2008.01657.x
更新日期：2008-04-01 00:00:00
abstract：:The regional distribution of neurones expressing aromatase mRNA in the ram hypothalamus was examined by in situ hybridization using 33P-labelled cRNA probes. The highest amounts of hybridization signal were observed in the central part of the medial preoptic nucleus and posterior medial part of the bed nucleus of the ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2000.00496.x
更新日期：2000-07-01 00:00:00
abstract：:The present study was carried out to characterize interleukin-1 (IL-1) receptors on murine pituitary cells. Receptor autoradiography confirmed the existence of binding sites for IL-1 alpha in the murine adenohypophysis, but not in the neural or intermediate lobes. Specific binding of IL-1 to isolated pituitary membran...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1993.tb00384.x
更新日期：1993-04-01 00:00:00
abstract：:The hypothalamic-neurohypophyseal system (HNS) mediates neuroendocrine responses to dehydration through the actions of the antidiuretic hormone vasopressin (VP) and the natriuetic peptide oxytocin (OT). VP and OT are synthesised as separate prepropeptide precursors in the cell bodies of magnocellular neurones in the h...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.2007.01604.x
更新日期：2007-11-01 00:00:00
abstract：:The mouse anterior pituitary contains both types of interleukin (IL)-1 receptors, IL-1 receptor type I (IL-1RI) and IL-1 receptor type II (IL-1RII). These receptors are expressed mainly on somatotroph cells. In the present study, the ability of the mouse pituitary to respond in vivo to IL-1 or to lipopolysaccharide (L...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2826.2003.01013.x
更新日期：2003-03-01 00:00:00
abstract：:Abstract Oxytocin- and vasopressin-binding sites were detected by autoradiography on films and on emulsion-coated sections of rat brains using highly selective [(125)|]-labelled oxytocin and vasopressin antagonists. Two distinct areas with high concentrations of oxytocin-binding sites were detected in the bed nucleus ...
journal_title：Journal of neuroendocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2826.1991.tb00335.x
更新日期：1991-12-01 00:00:00
