Regulation of rat APJ receptor messenger ribonucleic acid expression in magnocellular neurones of the paraventricular and supraopric nuclei by osmotic stimuli.


:The novel apelin receptor (APJ receptor, APJR) has a restricted expression in the central nervous system suggestive of an involvement in the regulation of body fluid homeostasis. The endogenous ligand for APJR, apelin, is also highly concentrated in regions that are involved in the control of drinking behaviour. While the physiological roles of APJR and apelin are not fully known, apelin has been shown to stimulate drinking behaviour in rats and to have a regulatory effect on vasopressin release from magnocellular neurones of the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. To determine the role of APJR in the regulation of water balance, this study examined the effects of osmotic stimulation on the expression of APJR mRNA in the magnocellular PVN (mPVN) and SON of salt-loaded and water-deprived rats. Intake of 2% NaCl and water deprivation for 48 h induced expression of APJR mRNA in the mPVN and SON. Using dual-label in situ hybridization histochemistry, we also investigated whether APJR is colocalized within vasopressin neurones in control, salt-loaded and water-deprived rats. APJR mRNA was found to colocalize with a small population of vasopressin-containing magnocellular neurones in control and water-deprived rats. Salt-loading resulted in an increased colocalization of APJR and vasopressin mRNAs in the SON. These data verify a role for APJ receptors in body fluid regulation and suggest a role for apelin in the regulation of vasopressin-containing neurones via a local autocrine/paracrine action of the peptide.


J Neuroendocrinol


O'Carroll AM,Lolait SJ




Has Abstract


2003-07-01 00:00:00














  • NF kappa B activation in mouse pituitary: comparison of response to interleukin-1 beta and lipopolysaccharide.

    abstract::The mouse anterior pituitary contains both types of interleukin (IL)-1 receptors, IL-1 receptor type I (IL-1RI) and IL-1 receptor type II (IL-1RII). These receptors are expressed mainly on somatotroph cells. In the present study, the ability of the mouse pituitary to respond in vivo to IL-1 or to lipopolysaccharide (L...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Parnet P,Pousset F,Laye S

    更新日期:2003-03-01 00:00:00

  • Anabolic androgenic steroid abuse: multiple mechanisms of regulation of GABAergic synapses in neuroendocrine control regions of the rodent forebrain.

    abstract::Anabolic androgenic steroids (AAS) are synthetic derivatives of testosterone originally developed for clinical purposes but are now predominantly taken at suprapharmacological levels as drugs of abuse. To date, almost 100 different AAS compounds that vary in metabolic fate and physiological effects have been designed ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Oberlander JG,Porter DM,Penatti CA,Henderson LP

    更新日期:2012-01-01 00:00:00

  • Role of oxytocin in parental behaviour.

    abstract::Both animal and human studies have provided conclusive evidence that oxytocin (OXT) acts in the brain (eg, medial preoptic area, ventral tegmental area, nucleus accumbens) to promote parental behaviour under different reproductive and physiological conditions. OXT appears to accelerate and strengthen the neural proces...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Olazábal DE

    更新日期:2018-07-01 00:00:00

  • Prolonged hormone secretion from neuroendocrine cells of Aplysia is independent of extracellular calcium.

    abstract::The role of Ca2+ from extracellular and intracellular sources in stimulating neurosecretion was investigated in four experiments using neuroendocrine bag cells of the marine mollusk Aplysia. (i) Bag cells were treated with either an extracellular calcium chelator (BAPTA) or Co(2+)-substitution within 30 s after onset ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Wayne NL,Kim J,Lee E

    更新日期:1998-07-01 00:00:00

  • Evidence for expression of galanin receptor Gal-R1 mRNA in certain gonadotropin releasing hormone neurones of the rostral preoptic area.

    abstract::Previous studies have shown that galanin plays an important role in the regulation of gonadotropin releasing hormone (GnRH) release. At present, it is not known if this role is exerted by direct or indirect interactions between galanin producing neurones and GnRH neurones. The objective of this study was to determine ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Mitchell V,Bouret S,Prévot V,Jennes L,Beauvillain JC

    更新日期:1999-10-01 00:00:00

  • Protocadherins and hypothalamic development: do they play an unappreciated role?

    abstract::Normal brain development requires coordinated cell movements at precise times. It has long been established that cell-cell adhesion proteins of the cadherin superfamily are involved in the adhesion and sorting of cells during tissue morphogenesis. In the present review, we focus on protocadherins, which form the large...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Coughlin GM,Kurrasch DM

    更新日期:2015-06-01 00:00:00

  • Voltage-induced Ca2+ release by ryanodine receptors causes neuropeptide secretion from nerve terminals.

    abstract::Depolarisation-secretion coupling is assumed to be dependent only on extracellular calcium ([Ca2+ ]o ). Ryanodine receptor (RyR)-sensitive stores in hypothalamic neurohypophysial system (HNS) terminals produce sparks of intracellular calcium ([Ca2+ ]i ) that are voltage-dependent. We hypothesised that voltage-elicited...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Velázquez-Marrero C,Custer EE,Marrero H,Ortiz-Miranda S,Lemos JR

    更新日期:2020-04-01 00:00:00

  • Noradrenergic regulation of hypothalamic cells that produce growth hormone-releasing hormone and somatostatin and the effect of altered adiposity in sheep.

    abstract::The growth hormone (GH) axis is sensitive to alteration in body weight and there is evidence that central noradrenergic systems regulate neurones that produce growth hormone-releasing hormone (GHRH) and somatostatin (SRIF). This study reports semiquantitative estimates of the noradrenergic input to neuroendocrine GHRH...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Iqbal J,Manley TR,Yue Q,Namavar MR,Clarke IJ

    更新日期:2005-06-01 00:00:00

  • Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin.

    abstract::Leptin plays a major role in coordinating the integrated response of the brain to changes in nutritional state. Leptin receptor expressing neurones within the arcuate nucleus (ARC) of the hypothalamus sense circulating leptin and densely innervate other regions of the hypothalamus, including the paraventricular nucleu...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Jovanovic Z,Tung YC,Lam BY,O'Rahilly S,Yeo GS

    更新日期:2010-08-01 00:00:00

  • Simultaneous Visualization of Vasopressin and Oxytocin mRNA- Containing Neurons in the Hypothalamus Using Non-Radioactive in situ Hybridization Histochemistry.

    abstract::In situ hybridization histochemistry (ISHH) using synthetic oligodeoxynucleotide probes has been used to demonstrate the sites of expression of mRNA for vasopressin (AVP) and oxytocin (OXT) in the rat brain. ISHH was performed with two types of non-radioactive probes, labelled with either alkaline phosphatase or 5'-bi...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Ichimiya Y,Emson PC,Christodoulou C,Gait MJ,Ruth JL

    更新日期:1989-04-01 00:00:00

  • Oestrogens and Progestagens: Synthesis and Action in the Brain.

    abstract::When steroids, such as pregnenolone, progesterone and oestrogen, are synthesised de novo in neural tissues, they are more specifically referred to as neurosteroids. These neurosteroids bind specific receptors to promote essential brain functions. Pregnenolone supports cognition and protects mouse hippocampal cells aga...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Rossetti MF,Cambiasso MJ,Holschbach MA,Cabrera R

    更新日期:2016-07-01 00:00:00

  • Characterization of gonadotrophin-releasing hormone precursor cDNA in the Old World mole-rat Cryptomys hottentotus pretoriae: high degree of identity with the New World guinea pig sequence.

    abstract::Regulation of pituitary gonadotrophins by the decapeptide gonadotrophin-releasing hormone 1 (GnRH1) is crucial for the development and maintenance of reproductive functions. A common amino acid sequence for this decapeptide, designated as 'mammalian' GnRH, has been identified in all mammals thus far investigated with ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Kalamatianos T,du Toit L,Hrabovszky E,Kalló I,Marsh PJ,Bennett NC,Coen CW

    更新日期:2005-05-01 00:00:00

  • Maternal photoperiodic programming enlightens the internal regulation of thyroid-hormone deiodinases in tanycytes.

    abstract::Seasonal rhythms in physiology are widespread among mammals living in temperate zones. These rhythms rely on the external photoperiodic signal being entrained to the seasons, although they persist under constant conditions, revealing their endogenous origin. Internal long-term timing (circannual cycles) can be reveale...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Sáenz de Miera C

    更新日期:2019-01-01 00:00:00

  • DAMGO suppresses both excitatory and inhibitory synaptic transmission in supraoptic neurones of mouse hypothalamic slice preparations.

    abstract::Opioid effects on synaptic transmission in the mouse supraoptic nucleus (SON) were investigated using whole-cell, patch-clamp techniques. The mu-opioid receptor agonist, [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin (DAMGO) decreased the amplitude of both evoked excitatory postsynaptic currents (eEPSCs) and inhibitory...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Honda E,Ono K,Inenaga K

    更新日期:2004-03-01 00:00:00

  • Sex differences in the distribution and abundance of androgen receptor mRNA-containing cells in the preoptic area and hypothalamus of the ram and ewe.

    abstract::Rams and ewes show a negative-feedback response to peripheral treatment with testosterone, with both sexes having a similar degree of suppression in luteinizing hormone (LH) secretion during the breeding season. At least part of the action of testosterone to suppress gonadotropin-releasing hormone/LH secretion is exer...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Scott CJ,Clarke IJ,Rao A,Tilbrook AJ

    更新日期:2004-12-01 00:00:00

  • Effect of growth hormone-releasing peptide-2 (GHRP-2) and GH-releasing hormone (GHRH) on the the cAMP levels and GH release from cultured acromegalic tumours.

    abstract::There is a difference between the sheep and rat somatotrophs in the response to growth hormone-releasing peptide-2 (GHRP-2), which raises the question of what the response may be in human somatotrophs. In the present study, cells were obtained from seven human acromegalic tumours and the effects of GHRP-2 were studied...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Chen C,Pullar M,Loneragan K,Zhang J,Clarke IJ

    更新日期:1998-06-01 00:00:00

  • Expression of corticotropin releasing factor (CRF), urocortin and CRF type 1 receptors in hypothalamic-hypophyseal systems under osmotic stimulation.

    abstract::The expression of corticotropin releasing factor (CRF) and urocortin in hypothalamic magnocellular neurones increases in response to osmotic challenge. To gain a better understanding of the physiological roles of CRF and urocortin in fluid homeostasis, CRF, urocortin and CRF type 1 receptor (CRFR-1) gene expression wa...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Imaki T,Katsumata H,Miyata M,Naruse M,Imaki J,Minami S

    更新日期:2001-04-01 00:00:00

  • Activation of vasopressin neurons in aging and Alzheimer's disease.

    abstract::The supraoptic (SON) and paraventricular nuclei (PVN) of the human hypothalamus are production sites of vasopressin (AVP) and oxytocin (OXT). Although the hypothalamus is affected in Alzheimer's disease (AD), previous work has not only shown that in these two nuclei no neurons are lost, neither during aging nor in AD,...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Lucassen PJ,Salehi A,Pool CW,Gonatas NK,Swaab DF

    更新日期:1994-12-01 00:00:00

  • The pregnancy-induced increase in baseline circulating growth hormone in rats is not induced by ghrelin.

    abstract::The elevation in baseline circulating growth hormone (GH) that occurs in pregnant rats is thought to arise from increased pituitary GH secretion, but the underlying mechanism remains unclear. Distribution, Fourier and algorithmic analyses confirmed that the pregnancy-induced increase in circulating GH in 3-week pregna...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: El-Kasti MM,Christian HC,Huerta-Ocampo I,Stolbrink M,Gill S,Houston PA,Davies JS,Chilcott J,Hill N,Matthews DR,Carter DA,Wells T

    更新日期:2008-03-01 00:00:00

  • Glucocorticoid enhances the neurotoxic actions of quinolinic acid in the striatum in a cell-specific manner.

    abstract::This study demonstrates that corticosterone can exacerbate the damaging effects of infused quinolinic acid (QA) on the dorsal striatum. Adult adrenalectomised male rats were pretreated subcutaneously with graded doses of corticosterone (0, 0.5, 2, 5, 20 and 40 mg/kg/day) for 2 days and then received a unilateral infus...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Ngai LY,Herbert J

    更新日期:2005-07-01 00:00:00

  • Effect of constant light, pinealectomy and guanosine triphosphate gamma-s on the density of melatonin receptors in the rat suprachiasmatic nucleus: a possible implication of melatonin action.

    abstract::We report here the effects of pinealectomy and exposition to constant light on the density of melatonin receptors in the suprachiasmatic nuclei of the rat using quantitative autoradiography. The B(max) values were significantly increased when the animals were maintained in constant light for 3 days (8.22 ± 0.95 fmol/m...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Gauer F,Masson-Pévet M,Pévet P

    更新日期:1992-08-01 00:00:00

  • Long slender cytoplasmic extensions: a common feature of neuroendocrine cells?

    abstract::We have recently developed a new method for visualisation of gut mucosal cells and demonstrated that enterochromaffin (EC) and enterochromaffin-like (ECL) cells possess cytoplasmic extensions. The aim of the present study was to characterise the morphology of D- and G-cells. The D-cells in the stomach differed morphol...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Hauso Ø,Gustafsson BI,Waldum HL

    更新日期:2007-09-01 00:00:00

  • A tumultuous transition to motherhood: Altered brain and hormonal responses in mothers with postpartum depression.

    abstract::Postpartum depression (PPD) is a common but complex condition that is poorly understood and multifactorial in aetiology. It is a condition that can compromise the mother's care for her infant, which may pose challenges to the formation of the mother-infant bond and the infant's overall development. Past research has l...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Nguyen AJ,Hoyer E,Rajhans P,Strathearn L,Kim S

    更新日期:2019-09-01 00:00:00

  • Circadian variation of plasma calcitonin gene-related Peptide in man.

    abstract::Abstract Calcitonin gene-related peptide (CGRP) is one of the most potent endogenous vasodilator peptides known so far. Almost all clinical studies using or measuring CGRP are conducted during the day, and hence this study was carried out to see any variations of CGRP levels in the circulation during this period. Thre...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Wimalawansa SJ

    更新日期:1991-06-01 00:00:00

  • Hypothalamic pituitary adrenal axis responses to low-intensity stressors are reduced after voluntary wheel running in rats.

    abstract::Regular physical exercise is beneficial for both physical and mental health. By contrast, stress is associated with deleterious effects on health and there is growing evidence that regular physical exercise counteracts some of the effects of stress. However, most previous studies have suggested that prior exercise doe...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Campeau S,Nyhuis TJ,Sasse SK,Kryskow EM,Herlihy L,Masini CV,Babb JA,Greenwood BN,Fleshner M,Day HE

    更新日期:2010-08-01 00:00:00

  • Seasonal variation of melatonin binding sites in the pars tuberalis of the male mink (Mustela vison).

    abstract::The seasonal changes of 2-[125I]iodomelatonin binding were studied using quantitative autoradiography in the pars tuberalis (PT) of the mink, a short-day breeder, kept out of doors. Studies were performed at 7 times of the year (July, September, October, January, February, and May), corresponding to different states o...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Messager S,Caillol M,George D,Martinet L

    更新日期:1997-07-01 00:00:00

  • Neuropeptide Y (NPY) delays the oestrogen-induced luteinizing hormone (LH) surge in the ovariectomized ewe: further evidence that NPY has a predominant negative effect on LH secretion in the ewe.

    abstract::Studies in rats suggest that neuropeptide Y (NPY) plays a stimulatory role in the generation of the preovulatory luteinizing hormone (LH) surge, via the Y1 receptor. We have investigated this issue using the oestradiol benzoate (EB)-treated ovariectomized (OVX) ewe which is a model for the preovulatory LH surge. A Y1 ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Estrada KM,Pompolo S,Morris MJ,Tilbrook AJ,Clarke IJ

    更新日期:2003-11-01 00:00:00

  • From sensory circumventricular organs to cerebral cortex: Neural pathways controlling thirst and hunger.

    abstract::Much progress has been made during the past 30 years with respect to elucidating the neural and endocrine pathways by which bodily needs for water and energy are brought to conscious awareness through the generation of thirst and hunger. One way that circulating hormones influence thirst and hunger is by acting on neu...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: McKinley MJ,Denton DA,Ryan PJ,Yao ST,Stefanidis A,Oldfield BJ

    更新日期:2019-03-01 00:00:00

  • The role of ascending neuronal pathways in stress-induced release of noradrenaline in the hypothalamic paraventricular nucleus of rats.

    abstract::Central catecholaminergic pathways carrying pain-related signals to the hypothalamic paraventricular nucleus (PVN) were investigated in laboratory rats. Four per cent formalin injected subcutaneously was employed as a stressful stimulus. Neuronal activity in brainstem catecholaminergic and paraventricular neurones was...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Palkovits M,Baffi JS,Pacak K

    更新日期:1999-07-01 00:00:00

  • Neonatal programming by neuroimmune challenge: effects on responses and tolerance to septic doses of lipopolysaccharide in adult male and female rats.

    abstract::A mild immune challenge experienced during the neonatal period leads to attenuated febrile responses to a similar challenge experienced later in life. However, the immune response to an endotoxin differs depending upon the severity of the challenge and it is not clear whether a neonatal immune challenge will also affe...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Spencer SJ,Field E,Pittman QJ

    更新日期:2010-04-01 00:00:00