The effect of gonadal steroids on vasoactive intestinal Peptide concentration and release from mediobasal hypothalamus and the anterior pituitary gland.


:Abstract The effects of chronic administration of sex steroids on the content of vasoactive intestinal peptide (VIP) in the mediobasal hypothalamus and anterior pituitary were studied in adult rats. Gonadectomy had no effect on VIP concentration in the mediobasal hypothalamus or anterior pituitary gland. Estradiol benzoate (1 mug/100 g body wt/day) administered for 10 days decreased mediobasal hypothalamus VIP concentration of ovariectomized rats whereas it produced no change in mediobasal hypothalamus VIP content of orchidectomized rats. Testosterone propionate (100 mug/100 g body wt/day) administration decreased mediobasal hypothalamus VIP content in both sexes. Estradiol administration caused an increase whereas testosterone treatment resulted in a decrease in anterior pituitary VIP levels in both sexes. The effect of chronic administration of the sex steroids on VIP release from the mediobasal hypothalamus and anterior pituitary was also investigated. Estradiol increased evoked VIP release from the mediobasal hypothalamus and decreased mediobasal hypothalamus VIP content whereas testosterone decreased both mediobasal hypothalamus release and content. Chronic treatment with estradiol enhanced anterior pituitary VIP release and content while testosterone decreased both parameters studied. The data indicate that anterior pituitary VIP content is under the control of gonadal hormones and that the increased anterior pituitary VIP found after estradiol administration may be due to an augmented release from the mediobasal hypothalamus and probably an increase in anterior pituitary VIP synthesis.


J Neuroendocrinol


Lasaga M,Duvilanski BH,Seilicovich A,Afione S,Diaz Mdel C,Pisera D,Traktenberg R,Debeljuk L




Has Abstract


1991-02-01 00:00:00














  • Sex differences and the roles of sex steroids in apoptosis of sexually dimorphic nuclei of the preoptic area in postnatal rats.

    abstract::The brain contains several sexually dimorphic nuclei that exhibit sex differences with respect to cell number. It is likely that the control of cell number by apoptotic cell death in the developing brain contributes to creating sex differences in cell number in sexually dimorphic nuclei, although the mechanisms respon...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Tsukahara S

    更新日期:2009-03-01 00:00:00

  • 6-hydroxydopamine lesions of the locus coeruleus induce a paradoxical increase in growth hormone secretion in male rats.

    abstract::While the pharmacology of noradrenaline effects on growth hormone (GH) secretion has been extensively studied, the precise localization of noradrenergic neurons involved remains unclear. In the present work, we investigated whether A6 noradrenergic neurons located in the locus coeruleus can play a role in the rhythmic...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Bluet-Pajot MT,Mounier F,Durand D,Kordon C,Llorens-Cortes C,Videau C,Epelbaum J

    更新日期:1992-02-01 00:00:00

  • Identification of dopamine, gonadotrophin-releasing hormone-I, and vasoactive intestinal peptide neurones activated by electrical stimulation to the medial preoptic area of the turkey hypothalamus: a potential reproductive neuroendocrine circuit.

    abstract::The neural and neurochemical substrates regulating reproduction in birds remain vaguely defined. The findings that electrical stimulation in the medial preoptic area (ES/MPOA) or intracerebroventricular infusion of dopamine (DA) stimulated luteinising hormone (LH) and prolactin (PRL) release in female turkeys, led to ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Al-Zailaie KA,Kang SW,Youngren OM,Thayananuphat A,Bakken T,Chaiseha Y,Millam JR,Proudman JA,El Halawani ME

    更新日期:2006-07-01 00:00:00

  • Microinfusion of a nitric oxide donor in discrete brain regions activates the hypothalamic-pituitary-adrenal axis.

    abstract::We previously showed that the intracerebroventricular injection of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1) released adrenocorticotropic hormone (ACTH) and upregulated transcripts for corticotropin-releasing factor (CRF) and vasopressin in the paraventricular nucleus (PVN) of the rat hypothalamus. ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Seo DO,Rivier C

    更新日期:2001-11-01 00:00:00

  • Photoperiod affects the ability of testosterone to alter proopiomelanocortin mRNA, but not luteinizing hormone-releasing hormone mRNA, levels in male sheep.

    abstract::This study tested the hypothesis that photoperiod affects the ability of testosterone to reduce proopiomelanocortin (POMC) mRNA levels in the arcuate nucleus and luteinizing hormone-releasing hormone (LHRH) mRNA levels in both the preoptic area (POA) or medial basal hypothalamus (MBH). Twenty castrated male sheep were...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Hileman SM,Kuehl DE,Jackson GL

    更新日期:1998-08-01 00:00:00

  • The role of vasopressin in the genetic and neural regulation of monogamy.

    abstract::Arginine vasopressin modulates pairbond formation in the monogamous prairie vole (Microtus ochrogaster). Our laboratory has investigated the genetic and neural mechanisms by which vasopressin and its V1a receptor (V1aR) regulate social attachment between mates. Non-monogamous vole species show strikingly different dis...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Lim MM,Hammock EA,Young LJ

    更新日期:2004-04-01 00:00:00

  • Oestrogen requires the insulin-like growth factor-I receptor for stimulation of prolactin synthesis via mitogen-activated protein kinase.

    abstract::Sex steroids and growth factors interact at the intracellular level in a variety of tissues to control numerous physiological functions. Oestrogen is known to stimulate prolactin synthesis and secretion, but the effect of insulin-like growth factor (IGF)-I is less clear. We used GH3 cells, a somatolactotroph cell line...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Arroba AI,Frago LM,Argente J,Chowen JA

    更新日期:2005-02-01 00:00:00

  • Pituitary hormone gene expression in male golden hamsters: interactions between photoperiod and testosterone.

    abstract::Abstract Daylength regulates neuroendocrine function in male golden hamsters. Exposure to short days triggers gonadal regression and decreases serum luteinizing hormone (LH), prolactin and testosterone concentrations. Inhibitory photoperiods also amplify the negative feedback actions of androgens upon gonadotropin sec...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Hegarty CM,Jonassen JA,Bittman EL

    更新日期:1990-10-01 00:00:00

  • Effect of constant light, pinealectomy and guanosine triphosphate gamma-s on the density of melatonin receptors in the rat suprachiasmatic nucleus: a possible implication of melatonin action.

    abstract::We report here the effects of pinealectomy and exposition to constant light on the density of melatonin receptors in the suprachiasmatic nuclei of the rat using quantitative autoradiography. The B(max) values were significantly increased when the animals were maintained in constant light for 3 days (8.22 ± 0.95 fmol/m...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Gauer F,Masson-Pévet M,Pévet P

    更新日期:1992-08-01 00:00:00

  • Hypothalamic Gonadotropin-Releasing Hormone Secretion: Methodological Aspects of in vitro Systems.

    abstract::Abstract The regulation of gonadotropin-releasing hormone (GnRH) secretion from the medial basal hypothalamus (MBH) of adult male rats has been studied using two types of in vitro methods, the dynamic superfusion and static incubation systems. We compared both systems for methodological features including stability of...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Wibullaksanakul S,Handelsman DJ

    更新日期:1991-04-01 00:00:00

  • Patch-clamp analysis of direct steroidal modulation of glutamate receptor-channels.

    abstract::Steroid hormones regulate the neuroendocrine and behavioral functions of the brain by using a number of diverse cellular mechanisms. Many steroids exert rapid electrophysiological effects on neurons, involving specific interactions with membrane components, such as neurotransmitter receptors. Previous studies suggest ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Wong M,Moss RL

    更新日期:1994-06-01 00:00:00

  • Interaction between glucocorticoids and corticotropin releasing hormone (CRH) in the regulation of the pituitary CRH receptor in vivo in the rat.

    abstract::Acute stress causes biphasic changes in corticotropin releasing hormone (CRH) receptor mRNA expression with an early decrease followed by an increase. However, in the absence of glucocorticoids in adrenalectomized rats, stress results in prolonged CRH receptor (CRH-R) mRNA loss, suggesting that interactions between gl...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Ochedalski T,Rabadan-Diehl C,Aguilera G

    更新日期:1998-05-01 00:00:00

  • Folic acid, but not folate, regulates different stages of neurogenesis in the ventral hippocampus of adult female rats.

    abstract::Folate is an important regulator of hippocampal neurogenesis, and folic acid is needed prenatally to reduce the risk of neural tube defects. Both high levels of folic acid and low levels of folate can be harmful to health because low levels of folate have been linked to several diseases while high folic acid supplemen...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Qiu W,Gobinath AR,Wen Y,Austin J,Galea LAM

    更新日期:2019-10-01 00:00:00

  • DAMGO suppresses both excitatory and inhibitory synaptic transmission in supraoptic neurones of mouse hypothalamic slice preparations.

    abstract::Opioid effects on synaptic transmission in the mouse supraoptic nucleus (SON) were investigated using whole-cell, patch-clamp techniques. The mu-opioid receptor agonist, [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin (DAMGO) decreased the amplitude of both evoked excitatory postsynaptic currents (eEPSCs) and inhibitory...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Honda E,Ono K,Inenaga K

    更新日期:2004-03-01 00:00:00

  • Photoperiod alters the time course of brain cyclooxygenase-2 expression in Siberian hamsters.

    abstract::Fever is initiated by activation of the arachidonic acid cascade and the biosynthesis of prostaglandins within the brain. Inducible cyclooxygenase (COX-2) is a rate-limiting enzyme in prostaglandin synthesis, and the number of blood vessels expressing COX-2 correlates with elevated body temperature following periphera...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Bilbo SD,Quan N,Prendergast BJ,Bowers SL,Nelson RJ

    更新日期:2003-10-01 00:00:00

  • Autoradiographic detection of oxytocin- and vasopressin-binding sites in various subnuclei of the bed nucleus of the stria terminalis in the rat. Effects of functional and experimental sexual steroid variations.

    abstract::Abstract Oxytocin- and vasopressin-binding sites were detected by autoradiography on films and on emulsion-coated sections of rat brains using highly selective [(125)|]-labelled oxytocin and vasopressin antagonists. Two distinct areas with high concentrations of oxytocin-binding sites were detected in the bed nucleus ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Kremarik P,Freund-Mercier MJ,Stoeckel ME

    更新日期:1991-12-01 00:00:00

  • Regulation of progestin receptor expression in the developing rat brain by a dopamine d1 receptor antagonist.

    abstract::Steroid receptors within the developing brain influence a variety of cellular processes that endure into adulthood, altering both behaviour and physiology. Therefore, it is important to understand how steroid receptor expression is regulated during early brain development. Most studies indicate that oestradiol, by act...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Olesen KM,Auger CJ,Auger AP

    更新日期:2007-07-01 00:00:00

  • Androgen receptor function during undernutrition.

    abstract::Hypothalamo-pituitary inhibition of reproductive function during undernutrition is well known, however, the physiological mechanisms leading to suppression of gonadotrophin secretion are not clear. A variety of studies have indicated that testicular negative feedback on LH secretion is enhanced during food restriction...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Dong Q,Rintala H,Handelsman DJ

    更新日期:1994-08-01 00:00:00

  • Glial aromatization decreases neural injury in the zebra finch (Taeniopygia guttata): influence on apoptosis.

    abstract::Emerging evidence suggests a neuroprotective role for oestrogens following damage to the vertebrate brain. Aromatase (oestrogen synthase) is rapidly transcribed and translated in glial cells around areas of neural damage in several vertebrates. However, the potential neuroprotection afforded by locally up-regulated gl...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Wynne RD,Saldanha CJ

    更新日期:2004-08-01 00:00:00

  • Involvement of Cholecystokinin in Food Intake: II. Lactational Hyperphagia in the Rat.

    abstract::Abstract The role of Cholecystokinin in the hyperphagia of lactation was studied by measuring the concentration of this hormone in plasma and cerebrospinal fluid in relation to food intake in lactating rats. Cholecystokinin was measured by high-performance liquid chromatography and radioimmunoassay in plasma and by ra...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Lindén A,Uvnäs-Moberg K,Forsberg G,Bednar I,Enerotht P,Södersten P

    更新日期:1990-12-01 00:00:00

  • A comparison between the effect of cholecystokinin octapeptide and apomorphine on ingestion of intraorally administered sucrose in male rats.

    abstract::The involvement of dopamine receptors in the inhibitory effect of Cholecystokinin octapeptide on ingestive behaviour was investigated. Male rats were infused intraorally with a 1 M solution of sucrose and the amount ingested after treatment with the dopamine receptor agonist apomorphine was compared with that after tr...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Bednar I,Qureshi GA,Södersten P

    更新日期:1992-12-01 00:00:00

  • Changes in the expression of corticotrophin-releasing hormone, mineralocorticoid receptor and glucocorticoid receptor mRNAs in the hypothalamic paraventricular nucleus induced by fornix transection and adrenalectomy.

    abstract::The paraventricular nucleus (PVN) in the hypothalamus receives inputs from the hippocampus The present study explored the influence of the hippocampus on genes mediating glucocorticoid feedback in the PVN. Accordingly, the expression of mRNAs for corticotrophin-releasing hormone (CRH), the mineralocorticoid receptor (...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Han F,Ozawa H,Matsuda KI,Lu H,De Kloet ER,Kawata M

    更新日期:2007-04-01 00:00:00

  • Hyper-reactive hypothalamo-pituitary-adrenocortical axis in rats bred for high anxiety-related behaviour.

    abstract::Psychiatric patients suffering from anxiety disorders or endogenous depression exhibit increased activity in their hypothalamo-pituitary-adrenocortical (HPA) axis. Recently, two Wistar rat lines, bred for high (HAB) and low (LAB) anxiety-related behaviour on the elevated plus-maze, were described as a unique psychopat...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Landgraf R,Wigger A,Holsboer F,Neumann ID

    更新日期:1999-06-01 00:00:00

  • Oxytocin administered centrally facilitates formation of a partner preference in female prairie voles (Microtus ochrogaster).

    abstract::Prairie voles (Microtus ochrogaster) are monogamous mammals that form male-female pair bonds. Partner preference formation, one component of the pair bond in prairie voles, occurs following male-female cohabitation and is facilitated by mating. The peptide hormone oxytocin is released during physical contact and parti...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Williams JR,Insel TR,Harbaugh CR,Carter CS

    更新日期:1994-06-01 00:00:00

  • Disruption of reproductive rhythms and patterns of melatonin and prolactin secretion following bilateral lesions of the suprachiasmatic nuclei in the ewe.

    abstract::To determine whether the photoperiodic responses of reproductive and prolactin (PRL) rhythms in the ewe requires an intact suprachiasmatic nucleus (SCN) driving the pineal rhythm of melatonin secretion, four groups of ovary-intact ewes over a 6-year period were subjected to bilateral (n = 40) or sham lesions (n = 15) ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Scott CJ,Jansen HT,Kao CC,Kuehl DE,Jackson GL

    更新日期:1995-06-01 00:00:00

  • Fos expression by naloxone in LHRH neurons of the mediobasal hypothalamus and effects of pentobarbital sodium in the proestrous rat.

    abstract::Because Fos is thought to be induced in neurons that are activated, we examined whether luteinizing hormone-releasing hormone (LHRH) neurons expressed Fos protein when they were stimulated by an opioid receptor antagonist naloxone (NAL), expecting to identify LHRH neurons which are regulated by opioid neurons directly...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Funabashi T,Jinnai K,Kimura F

    更新日期:1997-02-01 00:00:00

  • Analysis of steroid-induced genes in the rat preoptic area-anterior hypothalamus using a differential-display reverse transcriptase-polymerase chain reaction.

    abstract::Steroid hormones modulate a variety of physiological functions in the hypothalamus. We attempted to identify steroid-regulated genes in the rat preoptic area-anterior hypothalamus by comparing differentially expressed mRNAs. Adult female rats were ovariectomized and, 1 week later, a silastic capsule containing 17beta-...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Park S,Seong JY,Son GH,Kang SS,Lee S,Kim SR,Kim K

    更新日期:2001-06-01 00:00:00

  • Neuronal Uptake of Monoclonal Anti-Vasopressin Antibodies in vivo and Relationship with the Physiological Status of Vasopressin Neurosecretory Cells.

    abstract::Abstract Mouse monoclonal anti-vasopressin antibody was injected just above one hypothalamic paraventricular nucleus of the rat brain. Immunocytochemistry and morphometric analysis showed that the antibody was taken up by neurons with the size and stereotaxic distribution of vasopressin-producing neurons. Labelled neu...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Burlet A,Arahmani A,Tankosic P,Burlet C

    更新日期:1990-06-01 00:00:00

  • Preterm labour: tsunami waves?

    abstract::Preterm labour and birth can be delayed but are generally unstoppable, threatening the health of the mother-baby duo. This may be a result of peripheral signals prematurely recruiting the oxytocin neurones that co-ordinate the timing of birth and, via specialised activity and secretion patterns, drive uterine contract...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Douglas AJ

    更新日期:2010-09-01 00:00:00

  • Role of oxytocin in parental behaviour.

    abstract::Both animal and human studies have provided conclusive evidence that oxytocin (OXT) acts in the brain (eg, medial preoptic area, ventral tegmental area, nucleus accumbens) to promote parental behaviour under different reproductive and physiological conditions. OXT appears to accelerate and strengthen the neural proces...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Olazábal DE

    更新日期:2018-07-01 00:00:00