Abstract：
:In Drosophila the Toll family, a group of transmembrane proteins, plays crucial roles in the host defense against invading pathogens. Mammalian species also conserve this system as the Toll-like receptor (TLR) family, which includes more than 10 members that have been identified so far. Both the Toll and TLR families recognize various kinds of microorganisms through pathogen-associated molecular patterns. Mammalian TLRs are expressed on macrophages and dendritic cells and mediate the signal for cytokine release or upregulation of costimulatory molecules. These activities cooperatively generate host defense mechanisms. Recently, gene targeting experiments, including ours, have contributed much to clarifying not only the function but also the signaling mechanism of TLRs. TLR2 is essential for recognizing lipopeptides and lipoproteins from several microorganisms and also peptidoglycans derived from gram-positive bacteria. TLR4 recognizes lipopolysaccharides and lipoteichoic acids from gram-negative and- positive bacteria, respectively. Furthermore, TLR9 is critical for recognizing bacterial DNAs. Thus, TLRs distinguish various immunostimulatory molecular patterns. Although TLR9 can produce similar biological responses, studies with mutant mice lacking a TLR-associating protein, MyD88, showed that TLR signaling is differentially regulated among TLR family members. Here, we describe recent progress in elucidating the function and signaling mechanisms of the TLR family.
journal_name
Acta Odontol Scandjournal_title
Acta odontologica Scandinavicaauthors
Kaisho T,Akira Sdoi
10.1080/000163501750266701subject
Has Abstractpub_date
2001-06-01 00:00:00pages
124-30issue
3eissn
0001-6357issn
1502-3850journal_volume
59pub_type
杂志文章,评审abstract：:Objective: To follow up 2209 individuals in a longitudinal study and assess self-reported TMD pain, painful and non-painful comorbid conditions, and pain-related disability.Material and methods: During 2012-2014, questionnaires were sent to 2209 eligible individuals who had been screened for TMD pain each year during ...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016357.2020.1730000
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:Considering that patients' satisfaction is one of the most important goals in conducting removable dental prosthesis (RDP) therapy and the fact that there are many factors which influence this parameter, the present study aims to evaluate the expectation before and satisfaction after therapy with RDP in patie...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2012.654612
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:To examine the initial viscosity and adhesive strength of modern denture adhesives in vitro. MATERIALS AND METHODS:Three cream-type denture adhesives (Poligrip S, Corect Cream, Liodent Cream; PGS, CRC, LDC) and three powder-type denture adhesives (Poligrip Powder, New Faston, Zanfton; PGP, FSN, ZFN) were use...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2014.913309
更新日期：2014-11-01 00:00:00
abstract：:In a previous paper it was maintained that the effect of the permanent use of an anterior partial bite-raising splint was an intrusion of the front teeth and an eruption of the others. However, the effect might have been merely a change in the inclination of the front teeth. The present study comprised the same materi...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016358309162340
更新日期：1983-10-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of age on root resorption and distribution along different parts of the root during prolonged light force application. MATERIAL AND METHODS:Orthodontic appliances were placed in two groups of 30 rats (one group 6 weeks old, the other 9-12 months old), with contralateral sides as con...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016350801982522
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:To investigate the failure of 15 dental implants (Paragon/Zimmer) in relation to their surface quality. MATERIALS AND METHODS:The study comprised of 15 dental implants (7 mm D Advent Implant, 3.9 mm D apex design implant), which were followed from surgery to completion of prosthetic restorations. The implant...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2011.569507
更新日期：2011-11-01 00:00:00
abstract：:In a 5-year clinical trial it was observed that the marginal degradation of class-II amalgam restorations could be related to the bulk of the restoration. The association between the occlusal cavity depth and the marginal degradation was observed after 6 months and varied for the different types of alloy. Ridit scores...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016359109005888
更新日期：1991-04-01 00:00:00
abstract：OBJECTIVE:Toothbrush abrasion is significant in the development of tooth wear, particularly when combined with erosion. This in vitro study aimed to evaluate the impact of toothpaste slurry abrasivity and toothbrush filament stiffness on abrasion of eroded enamel. MATERIAL AND METHODS:Eroded enamel samples (hydrochlor...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016350802195041
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVE:Monocyte-derived macrophages (MDMs) ability to phagocytize and produce nitric oxide (NO) was tested against root-canal strains of Enterococcus faecalis submitted to alkaline stress. Root-canal strains were also compared with urine Enterococci. MATERIALS AND METHODS:Enterococcus faecalis were stressed with al...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016357.2018.1533142
更新日期：2019-03-01 00:00:00
abstract：:The aim of this study was to obtain information on restorative dental care in Finland and to analyze the changes in treatment over a 5-year period. A random sample of dentists was drawn from the registers of the health authorities and the dental association in Finland, and in the spring of 1997 a questionnaire was sen...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/000163501750157090
更新日期：2001-04-01 00:00:00
abstract：:Three composites, two microfilled (Heliosit and Silux) and one macrofilled (Prisma-Fil), were exposed to visible light from three different light units. The depth of the cure was estimated by measuring the length of the test specimen after removing the uncured material. The macrofilled composite cured to a greater dep...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016358409041127
更新日期：1984-02-01 00:00:00
abstract：:This randomized clinical trial was initiated to study the effect of two restorative procedures on the clinical quality and longevity of class-III resin restorations. The material consisted of 52 pairs of class-III restorations in the microfilled resin Silar completed with two modifications of the conventional acid-etc...
journal_title：Acta odontologica Scandinavica
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/00016359309040575
更新日期：1993-08-01 00:00:00
abstract：OBJECTIVE:To investigate the incidence and prevalence of developmental odontogenic cysts in children and adolescents and compare the features of the two most common types, dentigerous cyst and keratocystic odontogenic tumor (KCOT). STUDY DESIGN:A retrospective review in a series of 369 patients with all histological d...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2014.913192
更新日期：2014-11-01 00:00:00
abstract：:The color change resulting from storage in water was measured on a number of experimental and proprietary complex resins. The experimental resins contained varying amounts of amine (DEPT or DEBA), benzoyl-peroxide (BPO) and inhibitor (MHQ). The proprietary resins had earlier been analyzed as regards the composition of...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016358309162298
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:Since the properties of polymers can be influenced using electron-beam irradiation, the aim of this study was to investigate whether electron-beam post-curing can improve the mechanical properties of experimental denture base polymers. MATERIAL AND METHODS:Rectangular specimens of different experimental poly...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016350701278781
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:Guided by the conceptual framework of Gilbert and co-workers, this study assesses satisfaction with oral health as reported by 65-year-olds in Sweden and Norway, the relationship of socio-demographic factors, clinical and subjective oral health indicators with satisfaction of oral health, and the consistency ...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016350902908780
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:Sense of Coherence (SOC) has been associated with perceived oral health measures, but the contribution of SOC to clinical measures is still unclear. The aim of the present cross-sectional study was to evaluate the potential association between periodontal health outcomes, such as periodontal clinical paramete...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2016.1154601
更新日期：2016-07-01 00:00:00
abstract：:The purpose of the present investigation was to study prevalence of periodontal disease among 30 to 39-years-old from Oporto in the north of Portugal. In addition, an attempt was made to elucidate possible periodontal disease determinants in this population. A random sample consisting of a total of 322 individuals was...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/000163500750051746
更新日期：2000-10-01 00:00:00
abstract：OBJECTIVE:Previous results regarding human sex chromosome aneuploidies have shown that the X and Y chromosomes affect tooth size and morphology. This study looked for the effect of sex chromosome deficiency on permanent tooth crown heights. MATERIALS AND METHODS:The material, from the Finnish KVANTTI Research Project,...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2014.921327
更新日期：2014-11-01 00:00:00
abstract：:The influence of different stone mixing agents, impression materials and lubrication methods on the surface hardness of a stone die material has been evaluated. For one impression material the dimensional effect of the mixing agents and lubrication on the dies was also studied. The stone die material was mixed with wa...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357509004622
更新日期：1975-01-01 00:00:00
abstract：OBJECTIVE:The objective of this study is to evaluate clinical and patient reported outcomes of different bleaching products. MATERIALS AND METHODS:Thirty participants were randomly divided into three bleaching groups (n = 10). Bleaching was performed with high concentrations of hydrogen peroxide (HP) - Boost (40%) and...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章,随机对照试验
doi：10.1080/00016357.2017.1376111
更新日期：2018-01-01 00:00:00
abstract：:Three groups of extracted human teeth were sectioned longitudinally into experimental and control halves. The enamel surfaces of the three groups of teeth were pretreated with 37% H3PO4 for 1 min, 0.5 M NaClO3 for 2 h, or water rinsing for 10 min. The experimental halves of the three groups received an application of ...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016359609003538
更新日期：1996-10-01 00:00:00
abstract：INTRODUCTION:The aim of this study is to compare the root canal transportation with the PathFile-ProTaper recommended protocol, PathFile-ProTaper modified protocol and stainless steel K-flexofiles. METHODS:Forty-five ISO 15, 0.02 taper S-shaped Endo Training Blocks were divided randomly into three groups of 15 each an...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2013.805430
更新日期：2014-01-01 00:00:00
abstract：:The purpose of this study, comprising two parts, was to investigate the congruence between answers given by general dentists in questionnaires concerning prosthodontic services and the recorded information on the services actually performed by each dentist. In Part I it is investigated whether questionnaire reports of...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/000163599429048
更新日期：1999-02-01 00:00:00
abstract：:According to several studies on human populations, the mandible deviates on opening significantly more often to the left than to the right. An association between the asymmetry of opening and handedness has been suggested. The present study of 143 left-handed Finnish conscripts showed no significant difference from th...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章,评审
doi：10.3109/00016358909167309
更新日期：1989-04-01 00:00:00
abstract：OBJECTIVE:To investigate the expression of Wnt3a, Wnt10b, β-catenin and DKK1 in the periodontal ligament (PDL) during orthodontic tooth movement (OTM) in rats. MATERIALS AND METHODS:Nickel-titanium closed-coil springs were used to deliver an initial 50 g mesial force to the left maxillary first molars in 30 rats. The ...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2015.1090011
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate the plaque pH level and ureolytic activity among children and adults of Karen Hill tribes. METHODS:Thirty-four children aged 6-10 years and 46 adults aged 20-38 years were interviewed regarding oral hygiene practices, sucrose intake and betel chewing. Caries experience ...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2013.794952
更新日期：2014-04-01 00:00:00
abstract：:The purpose of this study was to determine the sensitivity, specificity, positive and negative predictive values for Corah's Dental Anxiety Scale (DAS) and two modified versions of it (MDAS; MDAS/4). A questionnaire was mailed to a simple random sample of 1,190 25-year-old residents in the west of Norway in 1997. Half...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/00016350050217091
更新日期：2000-12-01 00:00:00
abstract：:The present study describes a Swedish family in which the mother and her son were affected with signs of popliteal pterygium syndrome (PPS, OMIM 119500). Both individuals had bilateral complete cleft lip and palate, oral synechiae, paramedian pits on the lower lip, toe syndactyly and a piece of triangular skin overgro...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.1080/000163500429334
更新日期：2000-04-01 00:00:00
abstract：OBJECTIVE:The clinical features of the early stages of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in patients with breast cancer remain unclear. A retrospective cohort study was conducted of patients with breast cancer who received intravenous bisphosphonate (BP) treatment in a single center in order to cl...
journal_title：Acta odontologica Scandinavica
pub_type： 杂志文章
doi：10.3109/00016357.2014.887772
更新日期：2014-11-01 00:00:00
