[Prognostic value of DNA ploidy in prostatic cancer].

Abstract:

OBJECTIVE:To asses the prognostic value of deoxyribonucleic acid (DNA) ploidy in a group of patients with prostate cancer treated with adrogenic blockade. MATERIALS AND METHODS:A retrospective study on 136 patients with prostatic cancer having undergone androgenic blockade was carried out. The prognostic influence of age, T and M categories, Gleason score and flow cytometry-determined DNA ploidy from survival analyses. Univariate survival analysis was carried out following Kaplan-Meier's method, while for multivariate survival analysis Cox's proportional hazard model was used. RESULTS:The univariante analysis showed that T and M categories, Gleason score and DNA ploidy have prognostic value. The Cox's regression analysis identified DNA ploidy, metastasis and Gleason score as independent variables having prognostic potential. CONCLUSIONS:DNA ploidy has independent prognostic value in prostate cancer treated with androgenic blockade and improves the predictive potential of classical prognostic factors.

journal_name

Actas Urol Esp

authors

Martínez Jabaloyas JM,Ruiz Cerdá JL,Sanz Chinesta S,Jiménez A,Hernández M,Jiménez Cruz JF

doi

10.1016/s0210-4806(01)72616-2

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

283-90

issue

4

eissn

0210-4806

issn

1699-7980

pii

S0210-4806(01)72616-2

journal_volume

25

pub_type

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