Abstract:
:The use of the uniformly most powerful among the unbiased (UMPU) test was recently suggested for the study of gametic association between two polymorphic loci as an alternative to the Fisher's exact test (Zapata and Alvarez, 1997, Annals of Human Genetics 61, 71-77). However, the proposed test is not UMPU for two-sided alternatives. In this study, we present the UMPU test, discuss criticisms against the use of randomized tests, and compare the power of several tests. We show that, in many practical cases, the use of the UMPU test is less than desirable and propose the alternative adjusted-more extreme tables (A-MET) and the equal-tails (ET) tests. We suggest that some of the general arguments against the use of randomized tests can be alleviated by a newly proposed extended p-value definition.
journal_name
Biometricsjournal_title
Biometricsauthors
Fuchs Cdoi
10.1111/j.0006-341x.2001.00535.xsubject
Has Abstractpub_date
2001-06-01 00:00:00pages
535-8issue
2eissn
0006-341Xissn
1541-0420journal_volume
57pub_type
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