Abstract:
:For the meta-analysis of controlled clinical trials or epidemiological studies, in which the responses are at least approximately normally distributed, a refined test for the hypothesis of no overall treatment effect is proposed. The test statistic is based on a direct estimation function for the variance of the overall treatment effect estimator. As outcome measures, the absolute and the standardized difference between means are considered. In simulation studies it is shown that the proposed test keeps the prescribed significance level very well in contrast to the commonly used tests in the fixed effects and random effects model, respectively, which can become very liberal. Furthermore, just for using the proposed test it is not necessary to choose between the fixed effects and the random effects approach in advance.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Hartung J,Knapp Gdoi
10.1002/sim.791subject
Has Abstractpub_date
2001-06-30 00:00:00pages
1771-82issue
12eissn
0277-6715issn
1097-0258journal_volume
20pub_type
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