Abstract：
OBJECTIVE:To determine whether hypercholesterolaemia treatment with pravastatin causes modifications in plasma fibrinogen. DESIGN:Descriptive, prospective pharmacological intervention study, with two transversal cuts, one at the start and one after 6 months pravastatin treatment. SETTING:Health area located in the suburbs of Valencia. PATIENTS:Hypercholesterolaemia cases diagnosed de novo and treated with pravastatin for 6 months. Sample size was calculated for paired data with an alpha error of 0.05 and a beta error of 20%. The fibrinogen difference thought relevant was set at 40 mg/dl. Variability was deduced from a mini-sample of 15 cases, obtaining a total of 57 patients. Sex, age, height, weight, BMI, count, formula, globular sedimentation rate (GSR), glucaemia, total, HDL and LDL cholesterol, and triglycerides were recorded. MEASUREMENTS AND MAIN RESULTS:Mean age was 55.9, height 161.9 cm and initial weight 73.9 kg (mean BMI 28.1 kg/m(2)). After six months pravastatin treatment (10/20 mg/day) we found no significant differences in glucaemia, GSR or leukocytes. There were differences in weight, that fell by 1.5 kg (0.6 kg/m(2)), systolic pressure (4.3 mmHg) and diastolic pressure (2.7 mmHg) on average. We found the following differences for lipids: 42.3 mg/dl (15.2%) drop in mean total cholesterol, 27 mg/dl (14.5%) in LDL cholesterol, and 36.2 mg/dl (21.9%) in triglycerides. We found a mean increase in HDL cholesterol of 4.4 mg/dl. There was a mean drop of 43.7 mg/dl (11.9%) in fibrinogen. CONCLUSIONS:We found an 11.9% drop of plasma fibrinogen in patients with hypercholesterolaemia treated with pravastatin.
journal_name
Aten Primariajournal_title
Atencion primariaauthors
Murciano Revert J,Martínez-Lahuerta JJ,Aleixandre Porcar L,Debón Belda Mdoi
10.1016/s0212-6567(01)78824-5subject
Has Abstractpub_date
2001-04-15 00:00:00pages
417-21issue
6eissn
0212-6567issn
1578-1275pii
S0212-6567(01)78824-5journal_volume
27pub_type
杂志文章abstract：OBJECTIVE:To evaluate the economic impact in terms of the direct costs (health care costs) and the indirect costs (effects on production caused by mortality and morbidity) of diabetes mellitus (DM) in the Canary Islands (Spain) during 1998. DESIGN:The approach used was to study the cost of the disease through looking ...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：10.1016/s0212-6567(02)70526-x
更新日期：2002-02-28 00:00:00
abstract：OBJECTIVES:To calculate the number of hospital discharge reports (HDR) received in primary care for determined kinds of patients suffering chronic pathologies who need on-going care. To evaluate whether the reports' contents are of use to the family doctor's monitoring of the patient. DESIGN:Descriptive study. SETTIN...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：10.1016/s0212-6567(00)78687-2
更新日期：2000-10-15 00:00:00
abstract：OBJECTIVE:To analyze the diagnostic agreement rate between primary care, an asynchronous teledermatology consultation, and a conventional dermatology consultation. DESIGN:Prospective non-randomized concordance study. SETTING:Dermatology Service in Hospital Son Llàtzer (Palma de Mallorca) and primary care centers of S...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：10.1016/j.aprim.2008.11.012
更新日期：2009-10-01 00:00:00
abstract：OBJECTIVE:To study the adverse side-effects to medication and define their principle characteristics. DESIGN:A descriptive, crossover, observation study with no random distribution. SETTING:The population cared for at a Health Centre in Toledo. PATIENTS:Those over 15 years old during a 6-month period. MEASUREMENTS ...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：
更新日期：1994-09-30 00:00:00
abstract：:Nurse demand management (NDM) is an emerging concept that requires some useful clarification, not only for professionals and users but also for managers. The NDM was born in 2009 after the need to reorganize the flow of demand, but it has become more than this. NDM is understood as a program led by the primary care nu...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：10.1016/j.aprim.2017.10.011
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the efficacy of an educational intervention to minimise the prescription of those new medicines whose therapeutic effects are of little benefit. DESIGN:Controlled and randomised experimental study. SETTING:27 health centres in the province of Sevilla, Spain. PARTICIPANTS:376 general practitione...
journal_title：Atencion primaria
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1157/13080299
更新日期：2005-10-31 00:00:00
abstract：OBJECTIVE:To describe the evolution of the number of potential years of life lost (PYLL) because of AIDS in La Rioja between 1986 and 1993. DESIGN:Descriptive study. SETTING:Autonomous Community of La Rioja. PATIENTS AND OTHER PARTICIPANTS:Secondary data from the regional Register of AIDS cases in La Rioja, from the...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：
更新日期：1996-05-15 00:00:00
abstract：INTRODUCTION:Inadequate sleep patterns and insomnia are frequently linked and represent common sleep disorders among adolescents. The present study provides data on sleep patterns and insomnia among Portuguese adolescents. MATERIAL E METHODS:In a cross-sectional study we evaluated 6,919 students from the 7th to the 12...
journal_title：Atencion primaria
pub_type： 杂志文章,多中心研究
doi：10.1016/S0212-6567(14)70090-3
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the validity of a rapid serology test for diagnosing Helicobacter pylori infection in our area. DESIGN:Longitudinal, prospective study. SETTING:Urban primary care centre. MEASUREMENTS:As reference tests for defining the presence/absence of Helicobacter pylori, histology and the urease gastric m...
journal_title：Atencion primaria
pub_type： 临床试验,杂志文章
doi：10.1016/s0212-6567(01)78912-3
更新日期：2001-06-30 00:00:00
abstract：OBJECTIVES:To validate the Cockroft-Gault and the abbreviated Modification of Diet in Renal Disease (MDRD) formulas in a hypertense population aged over 60 and with blood pressure monitored in out-patients. To evaluate the prevalence of various stages of hidden chronic kidney disease in this population. DESIGN:Descrip...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：10.1157/13101799
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVES:To find the amount of non-compliance with medical treatment for Hypertension and its causes, and to describe the profile of non-compliant patients. DESIGN:A crossover study performed on two home visits. SETTING:A rural Health Centre at Calpe, Alicante. PATIENTS:The sample was obtained from the census of m...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：
更新日期：1997-09-15 00:00:00
abstract：INTRODUCTION:On the centenary of the foundation of the Paediatrics Society of Madrid, a tribute is presented to rural medical practice of that time, although there are few documents on the history of rural medicine. The main objective is to describe the context of the rural medical practice in the late 19th and beginni...
journal_title：Atencion primaria
pub_type： 历史文章,杂志文章
doi：10.1016/j.aprim.2015.05.008
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:To prepare and validate a tool to measure Basic Life Support (BLS) and semi-automatic defibrillator (SAD) skills adapted for use by health professionals in Primary Care Teams (PCT). To propose an updated version and demonstrate self-sufficiency of the team to use it in a training evaluation. DESIGN:Validatio...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：10.1016/j.aprim.2009.03.006
更新日期：2010-01-01 00:00:00
abstract：:The program of help to the smoker (PHS) consists of a systematic intervention upon the whole of the demanding population, identifying the smokers and acting on them with a short, concise advise in all visits. The results after 2 months of operation of the PHS in a primary care center are reported. Among 483 persons 10...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：OBJECTIVE:To quantify and describe the self-treatment existing among users requesting a consultation about an illness which had commenced in the previous 15 days. DESIGN:Observational prospective study. SETTING:Primary care in a semi-rural environment. Family Medicine Unit in Valls (Tarragona). PATIENTS AND OTHERS P...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：
更新日期：1993-03-15 00:00:00
abstract：OBJECTIVE:To discover the prevalence of serological markers of the Hepatitis B virus in the out-patient population of the city of Vigo. DESIGN:A year-long retrospective study (from January to December, 1990) of a total of 4,581 serums belonging to patients. These came to our laboratory from patients who attended the o...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：OBJECTIVE:To describe the situations of risk and the prevalence of HIV in women with a heterosexual partner infected by HIV. DESIGN:Cross-sectional descriptive study. SETTING:Out-patient HIV diagnosis centre in Madrid. PATIENTS:229 women seen for the first time between 1993 and 2002 because they had a stable heteros...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：10.1016/s0212-6567(04)78926-x
更新日期：2004-11-15 00:00:00
abstract：OBJECTIVE:The purpose of this study was the quantitative and qualitative analysis of the water in the reservoir and supply system to 27 villages of over 100 inhabitants or those which had a village council, within the Cistierna Health Area. DESIGN:It was a descriptive, longitudinal, prospective and observational study...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：
更新日期：1993-06-30 00:00:00
abstract：OBJECTIVE:The aim of this study was to identify multimorbidity patterns in patients from 19 to 44 years attended in primary care in Catalonia in 2010. DESIGN:Cross-sectional study. SETTING:251 primary care centres. PARTICIPANTS:530,798 people with multimorbidity, aged 19 to 44 years. MAIN OUTCOME MEASURES:Multimorb...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：10.1016/j.aprim.2015.10.006
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVES:The main aim was to calculate the prevalence of mental pathology in women between 18 and 70 in a Health District of Pamplona; second, to describe comorbidity and to analyse how mental pathology was recorded in the clinical histories. DESIGN:An observational crossover study with randomised selection. SETTIN...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：
更新日期：1998-03-31 00:00:00
abstract：OBJECTIVE:To investigate the habits and risk factors of adolescents from two Health Centres in two semi-urban populations using a structured clinical interview with open questions. DESIGN:Cross-sectional descriptive study. SETTING:Two semi-urban populations from the Malaga area. PARTICIPANTS:Adolescents aged between...
journal_title：Atencion primaria
pub_type： 杂志文章,多中心研究
doi：10.1016/j.aprim.2010.02.008
更新日期：2011-04-01 00:00:00
abstract：OBJECTIVE:To evaluate diagnostic concordance in the interpretation of electrocardiograms (ECG) between general practitioners and a referral cardiologist. DESIGN:Crossover and descriptive. SETTING:Seven General Medicine consulting rooms at Burgo de Osma Health Centre. PATIENTS AND OTHER PARTICIPANTS:318 ECGs included...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：
更新日期：1995-09-15 00:00:00
abstract：OBJECTIVES:To study internal communication between primary care health professionals DESIGN:Cross-sectional, descriptive. SETTING:Catalan Health Institute Costa de Ponent Primary Care Area, Spain. PARTICIPANTS:All workers in the area (n=3565). MEASUREMENTS:Three part questionnaire: a) sociodemographic questions; b)...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：10.1157/13125405
更新日期：2008-08-01 00:00:00
abstract：:The pandemic of the disease known as COVID-19 (acronym for coronavirus disease-2019), which was first detected in the Chinese city of Wuhan in December 2019, has led to an international public health emergency. This due to several reasons (threat to the lives of many people, unprecedented health and socioeconomic cris...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：10.1016/j.aprim.2020.09.004
更新日期：2020-11-01 00:00:00
abstract：OBJECTIVE:To study the use of single consultation in Primary Care/Psychiatry liaison. DESIGN:A retrospective study. SITE. Outpatients psychiatry department. Hospital Clínico Universitario. Zaragoza. PATIENTS OR OTHERS PARTICIPANTS:200 consecutive referrals. PERIOD:June-December 1992. MEASUREMENTS AND MAIN RESULTS:G...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：
更新日期：1994-02-28 00:00:00
abstract：OBJECTIVE:To assess the frequency of migraines attributable to continuous consumption of analgesics. DESIGN:A longitudinal prospective study of a descriptive type. SETTING:A specialised Neurology Clinic within a County hospital, which provides the Primary Care coverage for ibiza and Formentera. PATIENTS:All those pa...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：
更新日期：1994-06-15 00:00:00
abstract：OBJECTIVE:To describe the functional ability of elderly people and analyse its relationship to the use of services. DESIGN:A crossover study. SETTING:An urban population within the metropolitan area of the Community of Madrid. PARTICIPANTS:A random sample of 300 people over 70, taken from the municipal census. MEAS...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：
更新日期：1994-03-31 00:00:00
abstract：OBJECTIVES:To describe the type of relationship between primary care family doctors (PCDs) and the pharmaceutical industry (PI) and its representatives in Aragon, to describe doctors' attitudes to this relationship and to find out how doctors behave towards offers from the industry. DESIGN:Descriptive cross-sectional ...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：10.1016/s0212-6567(04)70840-9
更新日期：2004-09-30 00:00:00
abstract：OBJECTIVE:To assess the frequency of Candida species others than Candida albicans isolation, in patients with chronic as well as relapsing vaginitis. To analyze the clinical pictures and the treatments routinely employed in patients with Candida albicans infection, compared to those with other Candida species infection...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：
更新日期：1998-04-15 00:00:00
abstract：OBJECTIVE:To measure the correctness of decisions concerning counter-indications to vaccination (CV), taken by Primary Care professionals involved with the vaccination programme; to identify their associations with personal or organisational variables; and to sound out professionals' views on the source of false counte...
journal_title：Atencion primaria
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
