Follow-up of vertically HIV-1-infected long-surviving children.

Abstract:

:This study describes the clinical, immunologic, and virological characteristics of 30 vertically human immunodeficiency virus type 1 (HIV-1)-infected children older than 8 years of age (long-survivors) before the introduction of protease inhibitors therapy. All of them were followed from birth. At the age of 8 years, 7 children presented no HIV-1-associated signs or only mild ones and only 5 had severe clinical manifestations (acquired immune deficiency virus [AIDS]). The remaining 18 children presented moderate signs with some immunodeficiency. The follow-up from 8 years of age (3.5 years on the average) showed that 6 children remained asymptomatic and were therefore defined as long-survivors nonprogressors (average, 13 years) and only 4 children developed AIDS. Progressive encephalopathy was the most striking clinical manifestation at follow-up and occurred in 6 children (always after immunodeficiency) with a polymorphic picture combining eye movement alterations, pyramidal signs and symptoms and mental deterioration. The majority of our long-survivors carried a virus with nonsyncytia-inducing phenotype, thus confirming its association with long survival. A switch to syncytia-inducing phenotype was observed only in 2 cases during the follow-up, but their clinical status did not change at follow-up.

journal_name

AIDS Patient Care STDS

authors

Salvini F,Scarlatti G,Bossi A,Pinzani R,Zibordi F,Giovanettoni C,Plebani A

doi

10.1089/108729101300003645

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

59-65

issue

2

eissn

1087-2914

issn

1557-7449

journal_volume

15

pub_type

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