Abstract:
:The increased longevity afforded by combination antiretroviral therapy in developed countries has led to an increased concern regarding senescence-related diseases in patients with human immunodeficiency virus (HIV) infection. Previous epidemiologic analyses have demonstrated an increased risk of chronic obstructive pulmonary disease, as well as a significant burden of respiratory symptoms in HIV-infected patients. We performed the St. George's Respiratory Questionnaire (SGRQ) in 199 HIV-positive men, and determined the predominant factors contributing to poor respiratory-related health status. In univariate analyses, worse SGRQ scores were associated with respiratory-related variables such as greater smoking pack-year history (p=0.028), lower forced expiratory volume in 1 second (FEV1) (p<0.001), and worse emphysema severity as quantified by computed tomographic imaging (p=0.017). In addition, HIV-specific variables, such as a history of plasma viral load >100,000 copies/mL (p=0.043), lower nadir CD4 cell count (p=0.040), and current CD4 cell count ≤350 cells/μL (p=0.005), as well as elevated levels of inflammatory markers, specifically plasma interleukin (IL)-6 (p=0.002) and alpha-1 antitrypsin (p=0.005) were also associated with worse SGRQ scores. In a multiple regression model, FEV1, current CD4 count ≤350 cells/μL, and IL-6 levels remained significant contributors to reduced respiratory-related health status. HIV disease activity as measured by HIV-related immunosuppression in conjunction with the triggering of key inflammatory pathways may be important determinants of worse respiratory health status among HIV-infected individuals. Limitations of this analysis include the absence of available echocardiograms, diffusion capacity and lung volume testing, and an all-male cohort due to the demographics of the clinic population.
journal_name
AIDS Patient Care STDSjournal_title
AIDS patient care and STDsauthors
Leung JM,Liu JC,Mtambo A,Ngan D,Nashta N,Guillemi S,Harris M,Lima VD,Mattman A,Shaipanich T,Raju R,Hague C,Leipsic JA,Sin DD,Montaner JS,Man SFdoi
10.1089/apc.2013.0373subject
Has Abstractpub_date
2014-05-01 00:00:00pages
240-7issue
5eissn
1087-2914issn
1557-7449journal_volume
28pub_type
杂志文章abstract::The National HIV/AIDS Strategy (NHAS) calls for a reduction in health disparities, a reduction in new HIV infections, and improved retention in HIV care and treatment. It acknowledges that HIV-positive peers can play an important role in supporting these aims. However, peer training must be comprehensive enough to equ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.2011.0224
更新日期:2012-01-01 00:00:00
abstract::The objective of this study was to estimate racial/ethnic differences in retention in HIV care and viral suppression and to identify related individual and neighborhood determinants. Florida HIV surveillance records of cases aged ≥13 years diagnosed during the years 2000-2014 were analyzed. Retention in care was defin...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2016.0197
更新日期:2017-04-01 00:00:00
abstract::We explored the relationship between vitamin D levels and insulin resistance (IR) among 1082 nondiabetic (754 HIV-infected) women enrolled in the Women's Interagency HIV study (WIHS), a large and well-established cohort of HIV infected and uninfected women in the US. Vitamin D levels 20-29 ng/mL were considered insuff...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2012.0400
更新日期:2013-06-01 00:00:00
abstract::The introduction of protease inhibitors (PIs) and highly active antiretroviral therapy in the mid-1990s dramatically altered the treatment of HIV infection, enabling suppression of viral replication to undetectable levels and preventing disease progression. Most PIs present a strong barrier against viral resistance; t...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2007.0099
更新日期:2008-04-01 00:00:00
abstract::Chronic viral hepatitis has emerged as one of the leading causes of morbidity and mortality among HIV-positive patients. These individuals are at risk for aggressive chronic active hepatitis, cirrhosis, and hepatocellular carcinoma, and eventually, death. Currently available therapies for hepatitis B are limited and i...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729103322395456
更新日期:2003-09-01 00:00:00
abstract::The once daily, single-tablet regimen (STR) combining rilpivirine (RPV), emtricitabine (FTC), and tenofovir disoproxil fumarate (TDF) provides a simplified treatment option for antiretroviral therapy (ART)-naïve patients with baseline HIV-1 RNA (BLVL) of ≤100,000 copies/mL. The aim of this analysis is to compare long-...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,随机对照试验
doi:10.1089/apc.2013.0310
更新日期:2014-04-01 00:00:00
abstract::Low 25-hydroxyvitamin D levels are common in the general and HIV-infected populations alike. Defined as levels less than 30 ng/mL, suboptimal vitamin D is known to afflict over 70% of representative samples from each group in resource-rich countries with even greater prevalence in resource-poor regions of the world. I...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.2012.0145
更新日期:2012-09-01 00:00:00
abstract::Linking and engaging HIV-positive patients in care is the key bridging step to glean the documented health and prevention advantages of antiretroviral therapy (ART). In China, HIV transmission among men who have sex with men (MSM) is surging, yet many HIV-positive MSM do not use HIV care services. We conducted a quali...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2015.0296
更新日期:2016-02-01 00:00:00
abstract::Injection drug use (IDU) is an important vector of HIV infection in the United States. Many patients with HIV infection have comorbid substance use disorders. Integrated treatment for HIV and substance use disorders has been shown to improve HIV and other health outcomes, but significant barriers to integrated treatme...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2009.0242
更新日期:2010-01-01 00:00:00
abstract::Although rates of crystal methamphetamine use in the United States have fallen from their peak in the mid-2000s, use remains a major public health concern, which disproportionately affects gay and bisexual men (GBM). It poses a particular challenge for HIV-positive men, for whom it has been linked to medication adhere...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2016.0196
更新日期:2017-02-01 00:00:00
abstract::Hepatitis C virus (HCV) and HIV share the same parenteral routes of transmission. This common epidemiology explains the high frequency of combined infections by HCV and HIV. The aim of this review is to clarify some important issues dealing with the reciprocal impact of HIV and HCV-associated infections, including the...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.1998.12.11
更新日期:1998-01-01 00:00:00
abstract::Adherence to antiretroviral regimens is thought to be imperative for HIV-positive patients. However, little is known about health care professionals' willingness to discuss adherence with patients, nor what barriers, if any, may impede their adherence communication. The aims of the study were to examine physicians' be...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729100438854
更新日期:2000-09-01 00:00:00
abstract::Depression is highly prevalent among HIV-infected patients, yet little is known about the quality of HIV providers' depression treatment practices. We assessed depression treatment practices of 72 HIV providers at three academic medical centers in 2010-2011 with semi-structured interviews. Responses were compared to n...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2012.0406
更新日期:2013-03-01 00:00:00
abstract::Although many methods for assessing adherence have been developed, most are not feasible for busy clinical settings. Using patients from the Adherence and Efficacy of Protease inhibitor Therapy (ADEPT) study (1998-2000), we systematically evaluated the relationship between psychosocial, environmental, clinical, and ot...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2006.20.760
更新日期:2006-11-01 00:00:00
abstract::Hypogonadism and erectile dysfunction (ED) appear to be more common among men infected with HIV compared to age-matched men within the general U.S. population. HIV providers should consider these conditions and utilize standardized evaluation and diagnostic criteria. Treatment of both hypogonadism and ED increases sex...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.2005.19.655
更新日期:2005-10-01 00:00:00
abstract::Nationally representative data from the 2007 National Health Interview Survey (NHIS) were used to compare HIV testing prevalence among US adults with mental illness (schizophrenia spectrum disorder, bipolar disorder, depression, and/or anxiety) to those without, providing an update of prior work using 1999 and 2002 NH...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2014.0196
更新日期:2014-12-01 00:00:00
abstract::Gastrointestinal ulcerations in persons infected with HIV have many causes, the most common being opportunistic infections and neoplasms. Recently, idiopathic ulcerative lesions of the colon and rectum have been described. Two cases are reported of idiopathic colonic and anorectal inflammation and ulceration which fai...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.1998.12.903
更新日期:1998-12-01 00:00:00
abstract::The efficacy of highly active antiretroviral therapy (HAART) has been well documented, particularly among HIV-infected individuals with CD4 cell counts below 200/mm(3). Despite this, eligible individuals may continue to show some reluctance to use HAART. The present study explored the factors influencing patients' dec...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2006.20.848
更新日期:2006-12-01 00:00:00
abstract::HIV vaccine availability does not guarantee uptake. Given suboptimal uptake of highly efficacious and already accessible vaccines in the United States, low vaccine coverage in the developing world, and the expectation that initial HIV vaccines will be only partially efficacious, the public health community will face f...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/apc.2004.18.691
更新日期:2004-12-01 00:00:00
abstract::Despite the advent of effective antiretroviral therapy (ART), HIV-seropositive injection drug users (IDU) continue to suffer from elevated levels of morbidity and mortality. Evidence is needed to identify social- and structural-level barriers to effective ART. We investigated the impact of homelessness on plasma HIV R...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2011.0169
更新日期:2012-01-01 00:00:00
abstract::Thrombotic thrombocytopenic purpura (TTP) is a rare but well-described complication of HIV infection, which occurs equally frequently during the early asymptomatic phase of HIV infection and with clinical AIDS. The clinical spectrum varies from a low-grade asymptomatic thrombocytopenia with mild renal insufficiency to...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.1996.10.349
更新日期:1996-12-01 00:00:00
abstract::Despite successful implementation of anonymous voluntary human immunodeficiency virus (HIV) counseling and testing (aVCT) in Taiwan, the trend of late HIV presentation in sexually active populations has remained unchanged in Taiwan over the past decade. We evaluated the effect and acceptance of an aVCT cascade program...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2020.0044
更新日期:2020-07-01 00:00:00
abstract::To describe the epidemiology, outcomes, and risk factors of acute kidney injury (AKI) among human immunodeficiency virus (HIV)-infected patients admitted to the intensive care unit (ICU).We reviewed all the HIV-infected admissions to the ICU at Beijing Ditan hospital in the time span from June 2005 to May 2017 and col...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2018.0040
更新日期:2018-10-01 00:00:00
abstract::T-20 is a novel antiretroviral agent that inhibits the fusion of human immunodeficiency virus (HIV) with target cell membranes. It is delivered by self-administered, twice-daily, subcutaneous injections. The impact of this mode of administration on patients' ability to conduct normal activities of daily living (ADL) a...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729102320231162
更新日期:2002-07-01 00:00:00
abstract::Women living with HIV in high-income settings continue to experience modifiable barriers to care. We sought to determine the features of care that facilitate access to comprehensive primary care, inclusive of HIV, comorbidity, and sexual and reproductive healthcare. Using a systematic mixed studies review design, we r...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2017.0305
更新日期:2018-04-01 00:00:00
abstract::While debate continues at what stage of human immunodeficiency virus (HIV) disease to begin combination antiretroviral therapy, a number of clinical and public health benefits are linked to early entry into primary care soon after first testing HIV positive. However, HIV-infected patients continue to test late and del...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/108729101753205694
更新日期:2001-10-01 00:00:00
abstract::In recent years, AIDS and sexually transmitted diseases (STDs) have become a burgeoning problem and are spreading at an alarming rate. Microbicides are being developed as a new therapeutic category for prevention of transmission of sexually transmitted infections (STIs) and HIV. Many of the microbicide formulations (M...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章,评审
doi:10.1089/108729103322277402
更新日期:2003-08-01 00:00:00
abstract::Ten years after the Centers for Disease Control and Prevention recommended universal HIV screening, rates remain low. Internal medicine residents are the front-line medical providers for large groups of patients. We evaluated the knowledge of internal medicine residents about HIV testing guidelines and examined adhere...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2018.0035
更新日期:2018-05-01 00:00:00
abstract::We sought to determine the consequences of stopping highly active antiretroviral therapy (HAART) in a group of 41 HIV-infected individuals with undetectable HIV viral loads and CD4+ counts greater than 500 cells per microliter for 6 months or more. Clinical and laboratory parameters were monitored, as was the time to ...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2005.19.429
更新日期:2005-07-01 00:00:00
abstract::Previous investigational data using abacavir (ABC), lamuvidine (3TC), and zidovudine has suggested the possibility of triple nucleoside analogue reverse transcriptase inhibitors (NRTI) therapy as an option in the treatment of HIV infection. We performed a pilot study to assess the potency of once daily ABC+ 3TC+ tenof...
journal_title:AIDS patient care and STDs
pub_type: 杂志文章
doi:10.1089/apc.2005.19.135
更新日期:2005-03-01 00:00:00