Abstract:
:Rapid and precise compositional analysis of copoly (DL-lactic/glycolic acid) (PLGA) was performed by pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) combined with one-step hydrolysis and methylation in the presence of tetramethylammonium hydroxide (TMAH). Pyrolysis of PLGA with TMAH gave two characteristic products, derivatives of DL-lactic acid and glycolic acid, which directly reflect the average molar composition of PLGA. The analytical results for PLGA samples with various compositional ratios were in good agreement with those obtained by 1H-NMR spectrometry, and the precision was satisfactory.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Urakami K,Higashi A,Umemoto K,Godo M,Watanabe C,Hashimoto Kdoi
10.1248/cpb.49.203subject
Has Abstractpub_date
2001-02-01 00:00:00pages
203-5issue
2eissn
0009-2363issn
1347-5223journal_volume
49pub_type
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