Carcinoma of the cervix: results of a hyperbaric oxygen trial associated with the use of the cathetron.

Abstract:

:Since 1971, 82 patients with advanced carcinoma of the cervix have been included in a randomised clinical trial in association with the Working Party on Radiotherapy and Hyperbaric Oxygen of the Medical Research Council. External irradiation was given in 10 fractions by an unconventional schedule, either in air or HBO, and combined with three large fractions of intracavitary irradiation using the Cathetron. The results are acceptable overall, with 69% local control, 15% with tumour developing outside the treated volume and 40% survival at five years, but no improvement has been shown with HBO. Symptoms suggestive of some degree of late damage to the small bowel were present in 13% of patients, with a higher but not statistically significant, incidence in the HBO group. It is postulated that the schedule of radiotherapy used has allowed reoxygenation during treatment and that no further gain due to the use of HBO may be achieved. After a review of the results from other centres and taking into account the difficulties of treatment in HBO it is concluded that for advanced carcinoma of the cervix the addition of HBO to radiotherapy is not clinically worthwhile.

journal_name

Clin Radiol

journal_title

Clinical radiology

authors

Ward AJ,Dixon B

doi

10.1016/s0009-9260(79)80213-5

subject

Has Abstract

pub_date

1979-07-01 00:00:00

pages

383-7

issue

4

eissn

0009-9260

issn

1365-229X

pii

S0009-9260(79)80213-5

journal_volume

30

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1979-07-01 00:00:00

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