Possible role of the fetal adrenal glands in the etiology of postmaturity.

Abstract:

:Plasma cortisol levels were studied in the cord blood and neonatal blood of the following vaginally delivered groups: (A) postmature; (B) postterm (but not postmature); and (C) term neonates. Significantly lower levels of 8 A.M. neonatal plama cortisol were found in postmature neonates when compared with term neonates (P LESS THAN 0.02) or merely postterm neonates (P LESS THAN 0.02). No difference was found in the cord blood cortisol levels in all three groups. Contrary to the traditional belief that postmaturity results from placental aging, our findings appear to indicate that postmaturity represents a specific fetal disorder. Fetal adrenal insufficiency may be a characteristic of this disorder. Prolonged pregnancy in these cases may be reflected inability of the affected fetus to initiate labor.

journal_name

Am J Obstet Gynecol

authors

Nwosu U,Wallach EE,Boggs TR,Nemiroff RL,Bongiovanni AM

doi

10.1016/0002-9378(75)90013-7

subject

Has Abstract

pub_date

1975-02-01 00:00:00

pages

366-70

issue

3

eissn

0002-9378

issn

1097-6868

pii

0002-9378(75)90013-7

journal_volume

121

pub_type

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