Primary leiomyosarcoma of the pancreas: a case report and review of literature.

Abstract:

:Primary leiomyosarcoma of the pancreas is a rare tumor for which only 21 reports appear in the world literature. We describe an additional case of pancreatic leiomyosarcoma in a 76-year-old man, who complained of persistent high fever. Histologic examination revealed a pleomorphic spindle cell tumor. Reactivity for muscle-specific actin, alpha-smooth muscle actin, and basement membrane components, along with negative staining for epithelial and neural markers, were consistent with a smooth muscle sarcoma. The patient died of disease 1 year after complete surgical excision. This report highlights the need to use a complete antibody panel in order to accurately immunophenotype pleomorphic malignant tumors of the pancreas. A review of the cases compiled in the literature indicates that pancreatic leiomyosarcoma, like its counterpart arising in deep soft tissues, is an aggressive neoplasm characterized by short survival and a high rate of metastases.

journal_name

Arch Pathol Lab Med

authors

Nesi G,Pantalone D,Ragionieri I,Amorosi A

doi

10.1043/0003-9985(2001)125<0152:PLOTP>2.0.CO;2

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

152-5

issue

1

eissn

0003-9985

issn

1543-2165

journal_volume

125

pub_type

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