当前位置： SCI文献检索 > JOURNAL OF CLINICAL ANESTHESIA期刊下所有文献 > Rocuronium versus succinylcholine-atracurium for tracheal intubation and maintenance relaxation during propofol anesthesia.

Rocuronium versus succinylcholine-atracurium for tracheal intubation and maintenance relaxation during propofol anesthesia.

Abstract：

STUDY OBJECTIVES:To compare the onset and offset time (clinical duration), and intubating conditions obtained with rocuronium bromide 0.6 mg/kg and succinylcholine 1.0 mg/kg after induction with propofol and fentanyl; and to compare rocuronium with atracurium for maintenance during propofol anesthesia. DESIGN:Prospective, open-label, parallel group comparative, randomized study. SETTING:Operating rooms of a university hospital. PATIENTS:30 ASA physical status I and II adult patients scheduled for elective surgeries with general anesthesia. INTERVENTIONS:Patients premedicated with midazolam 2 mg were anesthetized with fentanyl 2 microg/kg followed by propofol 2.5 mg/kg and muscle relaxants. Group 1 (n = 15) received succinylcholine 1.5 mg/kg and Group 2 (n = 16) received rocuronium bromide 0.6 mg/kg. Intubation was performed 60 seconds after the administration of muscle relaxant. Patients in Group 1 received atracurium and patients in Group 2 received rocuronium for maintenance if required. MEASUREMENTS:The ease of intubation was scored using a scale of 1 to 4. Onset and offset time monitored with evoked twitch response of the adductor pollicis were recorded. MAIN RESULTS:Intubation was successful in all patients and there was no difference in scores between the two groups. Although onset time was shorter with succinylcholine than with rocuronium, neuromuscular blockade was successfully antagonized in both groups, and the recovery profile was not different between the two groups. CONCLUSIONS:Rocuronium bromide at a dose of 0.6 mg/kg, when used with propofol and fentanyl for induction, provides intubating conditions similar to succinylcholine 1.0 mg/kg at 1 minute. The actual onset time and offset time, however, are significantly longer with rocuronium. There was no difference between atracurium and rocuronium as a maintenance drug. Rocuronium is suitable for surgical procedures greater than 30 minutes, eliminating the need for an additional relaxant to succinylcholine.

journal_name

J Clin Anesth

journal_title

Journal of clinical anesthesia

authors

Lam AM,Pavlin EG,Visco E,Taraday J

doi

10.1016/s0952-8180(00)00191-4

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

449-53

issue

eissn

0952-8180

issn

1873-4529

pii

S0952-8180(00)00191-4

journal_volume

pub_type

临床试验,杂志文章,随机对照试验

在线工具

Rocuronium versus succinylcholine-atracurium for tracheal intubation and maintenance relaxation during propofol anesthesia.