Study of the melt pelletization process focusing on the micromeritic property of pellets.

abstract：:A series of benzylidene 2-aminoimidazolones derivatives were synthesized. Most compounds displayed strong inhibitory activity on the proliferation of human HepG2 cells in vitro. The active compounds were further evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against five human ca...

journal_title：Chemical & pharmaceutical bulletin

authors： Ling Y,Wang ZQ,Xiao YA,Zhu C,Shen L,Wang XM,Hui Y,Wang XY

更新日期：2013-01-01 00:00:00

abstract：:Three different sensitive and accurate spectroscopic procedures were developed for the determination of three angiotensin-converting enzyme inhibitors, namely, ramipril, enalapril maleate and fosinopril. The first two spectrophotometric (extractive and non-extractive) procedures were based on ternary complex formation...

journal_title：Chemical & pharmaceutical bulletin

authors： Baraka MM,El-Sadek M,Moussa EM,Abd-Alaty NM

更新日期：2008-11-01 00:00:00

abstract：:A new cycloartane bisdesmoside and two new trinorcycloartane glycosides, along with four known cycloartane compounds, were isolated from the rhizomes of Cimicifuga dahurica (Ranunculaceae). The structures of the new compounds were elucidated as 3-O-alpha-L-arabinopyranosyl cimigenol 15-O-beta-D-glucopyranoside, 24-hyd...

journal_title：Chemical & pharmaceutical bulletin

authors： Zhang QW,Ye WC,Hsiao WW,Zhao SX,Che CT

更新日期：2001-11-01 00:00:00

abstract：:Sixteen derivatives of 1-(beta-D-arabinofuranosyl)-2-thiocytosine (araSC), including five 5'-esters, three 3'-esters, five N4-amides and three 5'-phosphodiesters, were synthesized and their reactivity to mouse tissue homogenates, including plasma, liver and intestine, and antitumor activity in mice bearing P388 cells ...

journal_title：Chemical & pharmaceutical bulletin

authors： Kawaguchi T,Ichikawa T,Hasegawa T,Saneyoshi M,Wakayama T,Kato H,Yukita A,Nagata T

更新日期：2000-04-01 00:00:00

abstract：:Different green synthesis of alkyl esters of acyclovir (acyclovir prodrugs) is described. Hexanoic, decanoic, dodecanoic and tetradecanoic acyclovir esters were synthesized reacting acyclovir and the respective acid anhydride in dimethyl sulfoxide (DMSO), in solvents from renewable sources and without solvent (T=30 °C...

journal_title：Chemical & pharmaceutical bulletin

authors： de Regil-Hernández R,Martínez-Lagos F,Rodríguez-Bayón A,Sinisterra JV

更新日期：2011-01-01 00:00:00

abstract：:A series of 2-(4-methylphenyl)benzothiazoles was synthesized and evaluated using an adjuvant-induced arthritic rat model. This class of desired compounds affecting the immune response was found using hemagglutination assay. 4-Acetoxy-2-(4-methylphenyl)benzothiazole (7m), KB-2683, was most potent in the adjuvant-induce...

journal_title：Chemical & pharmaceutical bulletin

authors： Hori N,Tsukamoto G,Imamura A,Ohashi M,Saito T,Yoshino K

更新日期：1992-09-01 00:00:00

abstract：:The conjugation of Ulex europaeus agglutinin I (UEAI) onto surface of liposomes has been demonstrated to effectively improve the intestinal absorption of antigen, subsequently induced strong mucosal and systemic immune responses. In this context, we prepared bovine serum albumin (BSA)-encapsulating UEAI-modified lipos...

journal_title：Chemical & pharmaceutical bulletin

authors： Li K,Zhao X,Xu S,Pang D,Yang C,Chen D

更新日期：2011-01-01 00:00:00

abstract：:During a search for novel, orally-active inhibitors of upregulation of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1), we found a new series of 10H-pyrazino[2,3-b][1,4]benzothiazine derivatives to be potent ICAM-1 inhibitors. Of these compounds, N-[1-(10H-Pyrazino[2,3-b][1,4]benzothiazin-8-ylmet...

journal_title：Chemical & pharmaceutical bulletin

authors： Kaneko T,Clark RS,Ohi N,Kawahara T,Akamatsu H,Ozaki F,Kamada A,Okano K,Yokohama H,Muramoto K,Ohkuro M,Takenaka O,Kobayashi S

更新日期：2002-07-01 00:00:00

abstract：:A mechanism for the relatively high permeability of vitamin C in relation to the change in the protein domain of the stratum corneum has been proposed. Firstly, the skin permeation characteristics of vitamin C (l-[1-14C]-ascorbic acid) using whole skin and stripped skin of the hairless mouse were investigated. By empl...

journal_title：Chemical & pharmaceutical bulletin

authors： Lee AR,Tojo K

更新日期：1998-01-01 00:00:00

abstract：:Absorption spectra of polycrystalline L-, D-, and DL-tartaric acid have been measured by terahertz time domain spectroscopy (THz-TDS). Different absorption bands are observed for DL-tartaric acid and its enantiomers (L- and D-tartaric acid). This result shows that the THz-TDS can be used for distinguishing between DL-...

journal_title：Chemical & pharmaceutical bulletin

authors： Nishikiori R,Yamaguchi M,Takano K,Enatsu T,Tani M,de Silva UC,Kawashita N,Takagi T,Morimoto S,Hangyo M,Kawase M

更新日期：2008-03-01 00:00:00

abstract：:As part of a search for new potent derivatives, electrochemical oxidation of etoposide (1) was carried out under controlled potential (500 mV) to yield 1,2-dehydroetoposide (4), 4'-O-demethyl-1,2,3,4-tetradehydro-4-dehydroxy-podophyllotox in (5) and 1,2,3,4-tetradehydroetoposide (6). They showed no cytotoxicity agains...

journal_title：Chemical & pharmaceutical bulletin

authors： Obata R,Ohnuma T

更新日期：1993-10-01 00:00:00

abstract：:Hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC), a polymer in which a small amount of HPMC is stearoxyl substituted, was used as an emulsifier of emulsion-type lotion. A high-pressure homogenizer (microfluidizer) was used. The viscosity of the 1% HM-HPMC aqueous gel decreased after passing through the...

journal_title：Chemical & pharmaceutical bulletin

authors： Fujii M,Wada F,Honda N,Miura K,Hashizaki K,Taguchi H,Koizumi N,Watanabe Y

更新日期：2020-01-01 00:00:00

abstract：:To find a novel acyl-CoA: cholesterol acyltransferase inhibitor, a series of sulfamide derivatives were synthesized and evaluated. Compound 1d, in which carboxymethyl moiety at the 5-position of Pactimibe was replaced by a sulfamoylamino group, showed 150-fold more potent anti-foam cell formation activity (IC(50): 0.0...

journal_title：Chemical & pharmaceutical bulletin

authors： Takahashi K,Ohta M,Shoji Y,Kasai M,Kunishiro K,Miike T,Kanda M,Shirahase H

更新日期：2010-08-01 00:00:00

abstract：:Two series of new pyridines bearing thiazoline (3a--n) and thiazolidinone (5a--e) moieties were prepared via the cyclization of the corresponding substituted pyridyl thiourea (2a--g) with an appropriately substituted phenacyl bromide or chloroacetic acid, respectively. The antimicrobial activity was determined for rep...

journal_title：Chemical & pharmaceutical bulletin

authors： Hassan HY,el-Koussi NA,Farghaly ZS

更新日期：1998-05-01 00:00:00

abstract：:The sequence Fourier analysis reported previously seems to be applicable to elucidating a simple and concerted interaction in Arabidopsis thaliana, similar to that in Homo sapiens. ...

journal_title：Chemical & pharmaceutical bulletin

authors： Numao N,Miyama M,Hanagata N

更新日期：2004-08-01 00:00:00

abstract：:The sugar-inositol portion of the novel glycosylinositol-phosphoceramides, ZGL1 and ZGL2, from the filamentus fungi, Acremonium sp., were elucidated by a combination of NMR techniques including (1)H-(1)H (COSY and HOHAHA) and (1)H-(13)C (HMQC and HMBC) spectroscopy. Further, examination of the (1)H-(31)P HMQC spectrum...

journal_title：Chemical & pharmaceutical bulletin

authors： Yamada-Hada J,Hada N,Aoki K,Yamamoto K,Takeda T

更新日期：2004-04-01 00:00:00

abstract：:The direct conversion of alpha-hydroxy ketones and alpha-keto oximes into quinoxaline derivatives in the presence of a catalytic amount of ceric ammonium nitrate via metal-catalyzed aerobic oxidation followed by in situ trapping with aromatic 1,2-diamines in water as a green and efficient reaction media, is reported. ...

journal_title：Chemical & pharmaceutical bulletin

authors： Shaabani A,Maleki A

更新日期：2008-01-01 00:00:00

abstract：:Ten biscembranoids (1-10), including the two new compounds sarcophytolides M and N (1 and 2), were isolated from the methanol extract of the Vietnamese soft coral Sarcophyton pauciplicatum. Their structures were elucidated by spectroscopic methods including one dimensional (1D)- and 2D-NMR, high-resolution electrospra...

journal_title：Chemical & pharmaceutical bulletin

authors： Nam NH,Tung PT,Ngoc NT,Hanh TT,Thao NP,Thanh NV,Cuong NX,Thao do T,Huong TT,Thung do C,Kiem PV,Kim YH,Minh CV

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study was to predict the stability of octreotide in a mixed infusion containing sodium bisulfite (SBS). In aqueous solution the hydrolysis of octreotide was found to be accelerated by pH, and by increasing concentrations of SBS. Equations for the degradation rate constants (kobs) of pH and SBS were...

journal_title：Chemical & pharmaceutical bulletin

authors： Takasu Y,Yoshida M,Shimizu K,Asahara K,Tange M,Uchida T

更新日期：2014-01-01 00:00:00

abstract：:Tryptanthrin is an ancient medicine which recently was also found to have a function of downregulating multidrug resistance (MDR). However, tryptanthrin is insoluble in water, which limits its availability for delivery into cancer cells. There is a need to improve delivery systems to increase the inhibition of MDR. Th...

journal_title：Chemical & pharmaceutical bulletin

authors： Fang YP,Lin YK,Su YH,Fang JY

更新日期：2011-01-01 00:00:00

abstract：:From the quaternary alkaloidal fraction of the dried tubers of Stephania cepharantha, two new isoquinoline alkaloids, stecepharine and tetradehydroreticuline have been isolated along with the known compounds, magnoflorine, menisperine, steponine, cyclanoline, oblongine, cis-N-methylcapaurine and 2'-N-methylisotetrandr...

journal_title：Chemical & pharmaceutical bulletin

authors： Tanahashi T,Su U,Nagakura N,Nayeshiro H

更新日期：2000-03-01 00:00:00

abstract：:Three new anthraquinone glycosides, lasianthuoside A (1), B (2), and C (3), were isolated from the root of Lasianthus acuminatissimus MERR., The structural elucidation of these anthraquinones was mainly established on the basis of 1D and 2D NMR and HR-MS spectroscopic analysis. Ten known compounds, damnacanthol (4), d...

journal_title：Chemical & pharmaceutical bulletin

authors： Li B,Zhang DM,Luo YM,Chen XG

更新日期：2006-03-01 00:00:00

abstract：:When phenylalanine was irradiated at ultraviolet (UV) light, p-tyrosine, m-tyrosine and o-tyrosine were identified as hydroxylated products. From p-tyrosine and m-tyrosine, the formation of L-3,4-dihydroxyphenylalanine (DOPA) was observed. The hydroxylation of phenylalanine was prevented by radical scavengers, e.g., c...

journal_title：Chemical & pharmaceutical bulletin

authors： Ishimitsu S,Fujimoto S,Ohara A

更新日期：1990-05-01 00:00:00

abstract：:A quantitative structure property relationship (QSPR) study was performed to develop a model that relates the structures of 150 drug organic compounds to their aqueous solubility (log S(w)). Molecular descriptors derived solely from 3D structure were used to represent molecular structures. A subset of the calculated d...

journal_title：Chemical & pharmaceutical bulletin

authors： Ghasemi J,Saaidpour S

更新日期：2007-04-01 00:00:00

abstract：:1,4-Oxazepine formation reactions of 1,8-naphthyridine derivatives (1-4) with peroxy acid have been studied using a semiempirical MO method (AM1) and an ab initio molecular orbital method (Gaussian 94). The energies of molecules involved in the reaction paths were calculated and the transition states related to experi...

journal_title：Chemical & pharmaceutical bulletin

authors： Matsuzaki H,Takeuchi I,Hamada Y,Hatano K

更新日期：2000-05-01 00:00:00

abstract：:One novel sesquiterpene with new skeleton, (6S)-2-methyl-6-(4-hydroxyphenyl-3-methyl)-2-hepten-4-one (1), two new bisabolane sesquiterpenes, (6S)-2-methyl-6-(4-hydroxyphenyl)-2-hepten-4-one (2), (6S)-2-methyl-6-(4-formylphenyl)-2-hepten-4-one (3), and two calebin derivatives, 4''-(4'''-hydroxyphenyl-3'''-methoxy)-2''-...

journal_title：Chemical & pharmaceutical bulletin

authors： Zeng Y,Qiu F,Takahashi K,Liang J,Qu G,Yao X

更新日期：2007-06-01 00:00:00

abstract：:A new cardenolide diglycoside (1) was isolated from Nerium oleander together with ten known cardenolide diglycosides 2-11. The structure of compound 1 was established on the basis of their spectroscopic data. The in vitro anti-inflammatory activity of compounds 1-11 was examined on the basis of inhibitory activity aga...

journal_title：Chemical & pharmaceutical bulletin

authors： Zhao M,Bai L,Toki A,Hasegawa R,Sakai J,Hasegawa T,Ogura H,Kataoka T,Bai Y,Ando M,Hirose K,Ando M

更新日期：2011-01-01 00:00:00

abstract：:A new polyhydroxy sterol ester, (25S)-5alpha-cholestane-3beta,6alpha,7alpha,8,15alpha,16beta-hexahydroxyl-26-O-14'Z-eicosenoate (1), together with seven known steroid derivatives (2-8), were isolated from the EtOH extract of the whole body of China Sea starfish Asterina pectinifera. The structure of 1 was determined b...

journal_title：Chemical & pharmaceutical bulletin

authors： Peng Y,Zheng J,Huang R,Wang Y,Xu T,Zhou X,Liu Q,Zeng F,Ju H,Yang X,Liu Y

更新日期：2010-06-01 00:00:00

abstract：:Four new lanostane triterpene lactones (colossolactone I, colossolactone II, colossolactone III and colossolactone IV) were isolated from the Vietnamese mushroom Ganoderma colossum (FR.) C. F. BAKER along with five known compounds. The structures of the new compounds were determined on the basis of MS, NMR and circula...

journal_title：Chemical & pharmaceutical bulletin

authors： El Dine RS,El Halawany AM,Nakamura N,Ma CM,Hattori M

更新日期：2008-05-01 00:00:00

abstract：:A new glycosyl inositolphosphoceramide-type ganglioside, CSP2, was obtained from the polar lipid fraction of the chloroform/methanol extract of the feather star Comanthina schlegeli together with a known same type of ganglioside CJP2. The structure of this ganglioside has been determined on the basis of chemical and s...

journal_title：Chemical & pharmaceutical bulletin

authors： Inagaki M,Shiizaki M,Hiwatashi T,Miyamoto T,Higuchi R

更新日期：2007-11-01 00:00:00