Exercise immunology: neuroendocrine regulation of NK-cells.

Abstract:

:Natural immunity, including that of the natural killer (NK) cells, is strongly influenced by physical exercise, but the physiological significance of the reported changes in NK cells after exercise training is as yet unclear. The exercise effect is likely mediated by interactions between the central nervous and endocrine systems. Chronic activation of endogenous opioid systems augments natural cytotoxicity. We have investigated the possible involvement of opioids in the exercise-induced enhancement of NK cell function. The pathways by which the central nervous system may communicate with the periphery include neuroendocrine outflow via the hypothalamic-pituitary-adrenal axis and the autonomic nervous system (ANS) through direct nerve fiber connections with cells or the organs of the immune system. This review will discuss the role of various neuroendocrine factors such as growth hormone, catecholamines and glucocorticoids and the role of the ANS, in particular the sympathetic division, in modulating NK cell function in response to exercise.

journal_name

Int J Sports Med

authors

Jonsdottir IH

doi

10.1055/s-2000-1447

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

S20-3

eissn

0172-4622

issn

1439-3964

journal_volume

21 Suppl 1

pub_type

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