Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.

abstract：:The Wnt-1 proto-oncogene is essential for proper development of the midbrain and is expressed in a spatially and temporally restricted manner during central nervous system development in mice. In vitro, the gene is specifically transcribed during the retinoic acid (RA)-induced neuroectodermal differentiation of the P1...

journal_title：Molecular and cellular biology

authors： St-Arnaud R,Moir JM

更新日期：1993-03-01 00:00:00

abstract：:Pax family transcription factors bind DNA through the paired domain. This domain, which is comprised of two helix-turn-helix motifs and a beta-hairpin structure, is a target of mutations in congenital disorders of mice and humans. Previously, we showed that Pax-5 (B-cell-specific activator protein) recruits proteins o...

journal_title：Molecular and cellular biology

authors： Wheat W,Fitzsimmons D,Lennox H,Krautkramer SR,Gentile LN,McIntosh LP,Hagman J

更新日期：1999-03-01 00:00:00

abstract：:Cell polarity plays a critical role in the development of all metazoans; however, the mechanisms of cell polarity and the specific role of cell polarity pathways in mammalian organisms are still poorly understood. Lethal giant larvae (Lgl) is an apical-basal polarity gene identified in Drosophila, where it functions a...

journal_title：Molecular and cellular biology

authors： Sripathy S,Lee M,Vasioukhin V

更新日期：2011-07-01 00:00:00

abstract：:Mammalian poly(ADP-ribose) polymerase (PARP) is a nuclear chromatin-associated protein with a molecular mass of 114 kDa that catalyzes the transfer of ADP-ribose units from NAD+ to nuclear proteins that are located within chromatin. We report here the identification of a novel property of PARP as a modulator of nuclea...

journal_title：Molecular and cellular biology

authors： Miyamoto T,Kakizawa T,Hashizume K

更新日期：1999-04-01 00:00:00

abstract：:Total genomic DNA from a temperature-sensitive, colcemid-resistant Chinese hamster ovary (CHO) cell mutant expressing an electrophoretic variant beta-tubulin was used to transform wild-type CHO cells to colcemid-resistant cells at 37 degrees C. Southern blot analysis of the transformant demonstrated the three- to five...

journal_title：Molecular and cellular biology

authors： Whitfield C,Abraham I,Ascherman D,Gottesman MM

更新日期：1986-05-01 00:00:00

abstract：:Glucocorticoid-induced leucine zipper (GILZ) is a leucine zipper protein, whose expression is augmented by dexamethasone (DEX) treatment and downregulated by T-cell receptor (TCR) triggering. Stable expression of GILZ in T cells mimics some of the effects of glucocorticoid hormones (GCH) in GCH-mediated immunosuppress...

journal_title：Molecular and cellular biology

authors： Ayroldi E,Zollo O,Macchiarulo A,Di Marco B,Marchetti C,Riccardi C

更新日期：2002-11-01 00:00:00

abstract：:We investigated the role of RNA polymerase II (pol II) carboxy-terminal domain (CTD) phosphorylation in pre-mRNA processing coupled and uncoupled from transcription in Xenopus oocytes. Inhibition of CTD phosphorylation by the kinase inhibitors 5,6-dichloro-1beta-D-ribofuranosyl-benzimidazole and H8 blocked transcripti...

journal_title：Molecular and cellular biology

authors： Bird G,Zorio DA,Bentley DL

更新日期：2004-10-01 00:00:00

abstract：:We have characterized a pathway for nuclear export of the glucocorticoid receptor (GR) in mammalian cells. This pathway involves the Ca2+ -binding protein calreticulin (CRT), which directly contacts the DNA binding domain (DBD) of GR and facilitates its delivery from the nucleus to the cytoplasm. In the present study,...

journal_title：Molecular and cellular biology

authors： Holaska JM,Black BE,Rastinejad F,Paschal BM

更新日期：2002-09-01 00:00:00

abstract：:Intracellular degradation of vertebrate ornithine decarboxylase (ODC) is accelerated by polyamines, the products of the pathway controlled by ODC. Antizyme, a reversible, tightly binding protein inhibitor of ODC activity, is believed to be involved in this process. Mouse and Trypanosoma brucei ODCs are structurally si...

journal_title：Molecular and cellular biology

authors： Li X,Coffino P

更新日期：1992-08-01 00:00:00

abstract：:Following hepatic injury or stress, gluconeogenic and acute-phase response genes are rapidly upregulated to restore metabolic homeostasis and limit tissue damage. Regulation of the liver-restricted insulin-like growth factor binding protein 1 (IGFBP-1) gene is dramatically altered by changes in the metabolic state and...

journal_title：Molecular and cellular biology

authors： Leu JI,Crissey MA,Leu JP,Ciliberto G,Taub R

更新日期：2001-01-01 00:00:00

abstract：:The Msh2-Msh3 heterodimer recognizes various DNA mispairs, including loops of DNA ranging from 1 to 14 nucleotides and some base-base mispairs. Homology modeling of the mispair-binding domain (MBD) of Msh3 using the related Msh6 MBD revealed that mismatch recognition must be different, even though the MBD folds must b...

journal_title：Molecular and cellular biology

authors： Dowen JM,Putnam CD,Kolodner RD

更新日期：2010-07-01 00:00:00

abstract：:Recombinant type 1 transforming growth factor beta (TGF-beta) was expressed to high levels in CHO cells by using dihydrofolate reductase (dhfr) gene amplification. The expression plasmid was derived from the pSV2 vectors and contained, in tandem, the simian TGF-beta and mouse dhfr cDNAs. Transcription of both cDNAs wa...

journal_title：Molecular and cellular biology

authors： Gentry LE,Webb NR,Lim GJ,Brunner AM,Ranchalis JE,Twardzik DR,Lioubin MN,Marquardt H,Purchio AF

更新日期：1987-10-01 00:00:00

abstract：:Histone acetylation and deacetylation have been implicated in the regulation of gene expression. Molecular studies have shown that histone deacetylases (HDACs) function as transcriptional repressors. However, very little is known about their roles during development in multicellular organisms. We previously demonstrat...

journal_title：Molecular and cellular biology

authors： Dufourcq P,Victor M,Gay F,Calvo D,Hodgkin J,Shi Y

更新日期：2002-05-01 00:00:00

abstract：:Calpains regulate a wide spectrum of biological functions, including migration, adhesion, apoptosis, secretion, and autophagy, through the modulating cleavage of specific substrates. Ubiquitous microcalpain (μ-calpain) and millicalpain (m-calpain) are heterodimers composed of catalytic subunits encoded, respectively, ...

journal_title：Molecular and cellular biology

authors： Cataldo F,Peche LY,Klaric E,Brancolini C,Myers MP,Demarchi F,Schneider C

更新日期：2013-06-01 00:00:00

abstract：:Alpha interferon (IFN-alpha) and IFN-beta are able to interfere with viral infection. They exert a vast array of biologic functions, including growth arrest, cell differentiation, and immune system regulation. This regulation extends from innate immunity to cellular and humoral adaptive immune responses. A strict cont...

journal_title：Molecular and cellular biology

authors： Mesplède T,Island ML,Christeff N,Petek F,Doly J,Navarro S

更新日期：2005-10-01 00:00:00

abstract：:To examine a role for focal adhesion kinase (FAK) in cardiac morphogenesis, we generated a line of mice with a conditional deletion of FAK in nkx2-5-expressing cells (herein termed FAKnk mice). FAKnk mice died shortly after birth, likely resulting from a profound subaortic ventricular septal defect and associated mala...

journal_title：Molecular and cellular biology

authors： Hakim ZS,DiMichele LA,Doherty JT,Homeister JW,Beggs HE,Reichardt LF,Schwartz RJ,Brackhan J,Smithies O,Mack CP,Taylor JM

更新日期：2007-08-01 00:00:00

abstract：:The PKC1-associated mitogen-activated protein (MAP) kinase pathway of Saccharomyces cerevisiae regulates cell integrity by controlling the actin cytoskeleton and cell wall synthesis. Activation of PKC1 occurs via the GTPase RHO1 and the kinase pair PKH1 and PKH2. Here we report that YPK1 and YPK2, an essential pair of...

journal_title：Molecular and cellular biology

authors： Schmelzle T,Helliwell SB,Hall MN

更新日期：2002-03-01 00:00:00

abstract：:Growth differentiation factor 15 (GDF15) is a secreted protein with pleotropic functions from the transforming growth factor β (TGF-β) family. GDF15 is synthesized as a precursor and undergoes proteolytic cleavage to generate mature GDF15. The strong appetite-suppressing effect of mature GDF15 makes it an attractive t...

journal_title：Molecular and cellular biology

authors： Li JJ,Liu J,Lupino K,Liu X,Zhang L,Pei L

更新日期：2018-10-15 00:00:00

abstract：:The Wnt/β-catenin pathway promotes proliferation of neural progenitor cells (NPCs) at early stages and induces neuronal differentiation from NPCs at late stages, but the molecular mechanisms that control this stage-specific response are unclear. Pin1 is a prolyl isomerase that regulates cell signaling uniquely by cont...

journal_title：Molecular and cellular biology

authors： Nakamura K,Kosugi I,Lee DY,Hafner A,Sinclair DA,Ryo A,Lu KP

更新日期：2012-08-01 00:00:00

abstract：:The Rb protein is known to exert its activity at decision points in the G1 phase of the cell cycle. To investigate whether it may also play some role(s) at later points in the cell cycle, we used a system of rapid inducible gene amplification to conditionally overexpress Rb protein during G2 phase. A cell line express...

journal_title：Molecular and cellular biology

authors： Karantza V,Maroo A,Fay D,Sedivy JM

更新日期：1993-11-01 00:00:00

abstract：:The recently discovered nucleotide binding domain-leucine rich repeat (NLR) gene family is conserved from plants to mammals, and several members are associated with human autoinflammatory or immunodeficiency disorders. This family is defined by a central nucleotide binding domain that contains the highly conserved Wal...

journal_title：Molecular and cellular biology

authors： Ye Z,Lich JD,Moore CB,Duncan JA,Williams KL,Ting JP

更新日期：2008-03-01 00:00:00

abstract：:Sialic acid-binding immunoglobulin-like lectins (siglecs) are predominately expressed on immune cells. They are best known as regulators of cell signaling mediated by cytoplasmic tyrosine motifs and are increasingly recognized as receptors for pathogens that bear sialic acid-containing glycans. Most siglec proteins un...

journal_title：Molecular and cellular biology

authors： Tateno H,Li H,Schur MJ,Bovin N,Crocker PR,Wakarchuk WW,Paulson JC

更新日期：2007-08-01 00:00:00

abstract：:Glutamine is the preferred source of nitrogen of Neurospora crassa. In its presence and that of the gene product of MS5 (nmr-1), the fungus represses the assimilation of less preferred forms of nitrogen, such as nitrate. In the absence of glutamine and the presence of the product of gene nit-2, less preferred forms of...

journal_title：Molecular and cellular biology

authors： Sorger GJ,Brown D,Farzannejad M,Guerra A,Jonathan M,Knight S,Sharda R

更新日期：1989-09-01 00:00:00

abstract：:Human MED26 was originally purified in the cofactor required for the Sp1 activation complex (CRSP) as a 70-kDa component named CRSP70. This polypeptide was specific to metazoans and the “small” form of the Mediator complex. We report here that a Drosophila melanogaster homologue of MED26 similarly interacts with other...

journal_title：Molecular and cellular biology

authors： Marr SK,Lis JT,Treisman JE,Marr MT 2nd

更新日期：2014-07-01 00:00:00

abstract：:ADR1 is a yeast transcription factor that contains two zinc fingers of the Cys-2-His-2 (C2H2) class. Mutations that change the specificity of DNA binding of ADR1 to its target site, upstream activation sequence 1 (UAS1), have been identified at three positions in the first zinc finger. Mutations Arg-115 to Gln, His-11...

journal_title：Molecular and cellular biology

authors： Thukral SK,Morrison ML,Young ET

更新日期：1992-06-01 00:00:00

abstract：:The gene coding for the most abundant antifreeze protein (AFP) in the winter flounder was placed downstream of the Drosophila melanogaster hsp70 promoter and introduced into the D. melanogaster germ line by P-element-mediated transformation. In each of six transgenic strains tested, heat shock treatment induced the ex...

journal_title：Molecular and cellular biology

authors： Rancourt DE,Walker VK,Davies PL

更新日期：1987-06-01 00:00:00

abstract：:Expression of the recombinant human U1-70K protein in COS cells resulted in its rapid transport to the nucleus, even when binding to U1 RNA was debilitated. Deletion analysis of the U1-70K protein revealed the existence of two segments of the protein which were independently capable of nuclear localization. One nuclea...

journal_title：Molecular and cellular biology

authors： Romac JM,Graff DH,Keene JD

更新日期：1994-07-01 00:00:00

abstract：:The transcriptional coactivators p300 and CREB binding protein (CBP) are important regulators of the cell cycle, differentiation, and tumorigenesis. Both p300 and CBP are targeted by viral oncoproteins, are mutated in certain forms of cancer, are phosphorylated in a cell cycle-dependent manner, interact with transcrip...

journal_title：Molecular and cellular biology

authors： Snowden AW,Anderson LA,Webster GA,Perkins ND

更新日期：2000-04-01 00:00:00

abstract：:During mammalian dosage compensation, one of two X-chromosomes in female cells is inactivated. The choice of which X is silenced can be imprinted or stochastic. Although genetic loci influencing the choice decision have been identified, the primary marks for imprinting and random selection remain undefined. Here, we e...

journal_title：Molecular and cellular biology

authors： Boumil RM,Ogawa Y,Sun BK,Huynh KD,Lee JT

更新日期：2006-03-01 00:00:00

abstract：:By assessing the contribution of deregulated E2F activity to erythroid defects in Rb null mice, we have identified E2f-2 as being upregulated in end-stage red cells, where we show it is the major pRb-associated E2f and the predominant E2f detected at key target gene promoters. Consistent with its expression pattern, E...

journal_title：Molecular and cellular biology

authors： Dirlam A,Spike BT,Macleod KF

更新日期：2007-12-01 00:00:00