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Neurological phenotype in Waardenburg syndrome type 4 correlates with novel SOX10 truncating mutations and expression in developing brain.

Abstract：

:Waardenburg syndrome type 4 (WS4), also called Shah-Waardenburg syndrome, is a rare neurocristopathy that results from the absence of melanocytes and intrinsic ganglion cells of the terminal hindgut. WS4 is inherited as an autosomal recessive trait attributable to EDN3 or EDNRB mutations. It is inherited as an autosomal dominant condition when SOX10 mutations are involved. We report on three unrelated WS4 patients with growth retardation and an as-yet-unreported neurological phenotype with impairment of both the central and autonomous nervous systems and occasionally neonatal hypotonia and arthrogryposis. Each of the three patients was heterozygous for a SOX10 truncating mutation (Y313X in two patients and S251X [corrected] in one patient). The extended spectrum of the WS4 phenotype is relevant to the brain expression of SOX10 during human embryonic and fetal development. Indeed, the expression of SOX10 in human embryo was not restricted to neural-crest-derived cells but also involved fetal brain cells, most likely of glial origin. These data emphasize the important role of SOX10 in early development of both neural-crest-derived tissues, namely melanocytes, autonomic and enteric nervous systems, and glial cells of the central nervous system.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Touraine RL,Attié-Bitach T,Manceau E,Korsch E,Sarda P,Pingault V,Encha-Razavi F,Pelet A,Augé J,Nivelon-Chevallier A,Holschneider AM,Munnes M,Doerfler W,Goossens M,Munnich A,Vekemans M,Lyonnet S

doi

10.1086/302895

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

1496-503

issue

5

eissn

0002-9297

issn

1537-6605

pii

S0002-9297(07)62979-6

journal_volume

66

pub_type

杂志文章

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