Time to Treatment: A Crucial Factor in Thrombolysis and Primary Angioplasty.

abstract：:Acutely ill medical patients are at significant risk of venous thromboembolism (VTE). Thromboprophylaxis can substantially reduce the incidence of VTE, but to be optimally effective must consist of the correct choice of agent, at an appropriate dose, and for sufficient duration. Increasing evidence suggests that VTE r...

journal_title：Journal of thrombosis and thrombolysis

authors： Stark JE,Smith WJ

更新日期：2011-10-01 00:00:00

abstract：:Although clinical evidence supports a plausible association between thyroid disorders and venous thrombosis, reliable evidence is so far lacking on the potential biological mechanisms and neither temporary nor permanent thromboembolic risk factors were constantly identified. We performed a 2-years retrospective analys...

journal_title：Journal of thrombosis and thrombolysis

authors： Lippi G,Franchini M,Targher G,Montagnana M,Salvagno GL,Guidi GC,Favaloro EJ

更新日期：2009-10-01 00:00:00

abstract：:D-dimer levels are increased in patients with acute pulmonary embolism (PE). However, D-dimer levels are also increased in patients with community-acquired pneumonia (CAP). The aim of this prospective cohort study was to examine the incidence and clinical features of patients preliminarily diagnosed with CAP and with ...

journal_title：Journal of thrombosis and thrombolysis

authors： Zhang Y,Zhou Q,Zou Y,Song X,Xie S,Tan M,Zhang G,Wang C

更新日期：2016-05-01 00:00:00

abstract：:Schistosomes are parasitic platyhelminths that currently infect over 200 million people and cause the chronic debilitating disease schistosomiasis. While these large intravascular parasites can disturb blood flow, surprisingly they do not appear to provoke thrombus formation around them in vivo. In order to determine ...

journal_title：Journal of thrombosis and thrombolysis

authors： Da'dara AA,de Laforcade AM,Skelly PJ

更新日期：2016-05-01 00:00:00

abstract：INTRODUCTION:Recent investigations show that activated factor VII, the primary enzyme in the extrinsic pathway of blood coagulation, exerts additional extra-coagulant functions, such as apoptosis and angiogenesis. On the basis of these recent acquisitions, the present study was aimed to evaluate activated factor VII in...

journal_title：Journal of thrombosis and thrombolysis

authors： Volpe A,Salvagno GL,Lippi G,Caramaschi P,Montagnana M,Canestrini S,Carletto A,Bambara LM,Biasi D,Guidi GC

更新日期：2006-10-01 00:00:00

abstract：:Anticoagulation for the prevention of stroke is an important aspect of the management of atrial fibrillation. Novel anticoagulants including oral factor Xa inhibitors rivaroxaban and apixaban and the direct thrombin inhibitor dabigatran have emerged as important therapeutic treatment options for prevention of stroke i...

journal_title：Journal of thrombosis and thrombolysis

authors： DeWald TA,Becker RC

更新日期：2014-01-01 00:00:00

abstract：:Fibrinolysis is regulated by the thrombin/thrombin-activatable fibrinolysis inhibitor (TAFI) system. Thus, anticoagulants and inhibitors of TAFI are expected to accelerate fibrinolysis. The combined effects of an anticoagulant and a TAFIa inhibitor on fibrinolysis remain unknown. The aim of this study was to evaluate ...

journal_title：Journal of thrombosis and thrombolysis

authors： Morishima Y,Kamisato C,Honda Y

更新日期：2020-01-01 00:00:00

abstract：:The adverse impact of the development of cardiogenic shock in the setting of acute myocardial infarction was first described by Killip and Kimball in 1967. While the in-hospital mortality rate in patients with myocardial infarction and no evidence of heart failure was only 6%, the mortality rate in those patients who ...

journal_title：Journal of thrombosis and thrombolysis

authors： Levine GN,Hochman JS

更新日期：1995-01-01 00:00:00

abstract：:The effect of taurine on the plasma levels of L-arginine, asymmetrical dimethylarginine (ADMA) and L-arginine/ADMA ratio and nitric oxide was investigated in experimental endotoxemia. L-arginine and ADMA levels were quantified by high performance liquid chromatography with fluorescence detector. Nitric oxide level was...

journal_title：Journal of thrombosis and thrombolysis

authors： Balabanli B,Erdamar H,Türközkan N,Yaman H,Kurt Y

更新日期：2007-08-01 00:00:00

abstract：:Drug-eluting stents (DES) reduce the incidence of in-stent restenosis (ISR) after primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI). Whether the use of biomarkers might be of utility to identify patients who remain at risk for DES ISR after primary PCI has never been exami...

journal_title：Journal of thrombosis and thrombolysis

authors： Claessen BE,Stone GW,Mehran R,Witzenbichler B,Brodie BR,Wöhrle J,Witkowski A,Guagliumi G,Zmudka K,Henriques JP,Tijssen JG,Sanidas EA,Chantziara V,Hakim D,Leon S,Xu K,Dangas GD

更新日期：2012-08-01 00:00:00

abstract：:Warfarin is among the ten drugs most commonly involved in adverse drug reactions, has a narrow therapeutic index and complex dosage regimen, exhibits enormous variability dose-response and high risk drug-drug interactions. To analyze the profile of pharmacoepidemiological drug prescriptions for warfarin in patients ad...

journal_title：Journal of thrombosis and thrombolysis

authors： Guidoni CM,Obreli-Neto PR,Pereira LR

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:There are several new strategies proposed to improve the outcome of patients with ST-elevation myocardial infarction (STEMI). One approach is the resurgent use of facilitated percutaneous coronary interventions (PCI). Until recently, deciding whether immediate PCI after combined treatment (facilitated PCI) i...

journal_title：Journal of thrombosis and thrombolysis

authors： Di Pasquale P,Cannizzaro S,Parrinello G,Giambanco F,Vitale G,Fasullo S,Scalzo S,Ganci F,La Manna N,Sarullo F,La Rocca G,Paterna S

更新日期：2006-04-01 00:00:00

abstract：:Inherited afibrinogenemia and hypofibrinogenemia are rare bleeding disorders characterized by markedly reduced levels of fibrinogen in blood. Thrombotic complications in these disorders have been rarely described. We performed a multicenter retrospective study and reviewed the occurrence of thrombotic complications am...

journal_title：Journal of thrombosis and thrombolysis

authors： Rottenstreich A,Lask A,Schliamser L,Zivelin A,Seligsohn U,Kalish Y

更新日期：2016-08-01 00:00:00

abstract：:Several autopsy studies showed microthrombi in pulmonary circulation of severe COVID-19 patients. The major limitation of these investigations is that the autopsy provided static information. Some of these alterations could be secondary to the disseminated intravascular coagulation (DIC) observed as the final standard...

journal_title：Journal of thrombosis and thrombolysis

authors： do Espírito Santo DA,Lemos ACB,Miranda CH

更新日期：2020-11-01 00:00:00

abstract：:Pulmonary embolism (PE) is a leading cause of cardiovascular mortality. We intended to evaluate the awareness and management status of PE among Chinese physicians and provide the basis for establishing Chinese clinical guidelines on PE. We designed a nationwide survey to collect data on physicians' awareness of diagno...

journal_title：Journal of thrombosis and thrombolysis

authors： Zhang M,Zhang YX,Zhang Z,Wang J,Shao X,Xie WM,Wan J,Zhai ZG,Wang C

更新日期：2019-04-01 00:00:00

abstract：:Objective: To define the changing incidence, risk, and therapy of acute myocardial infarction (A311). Data sources: Review of contemporary AMI data from the University of Alberta Hospitals, six other sites of the Clinical Quality Improvement Network (CQIN), and other Canadian and international centers. Data synthesis:...

journal_title：Journal of thrombosis and thrombolysis

authors： Montague T,Montague P,Barnes M,Taylor L,Wowk L,Fassbender K,Ackman M,Martin S,Armstrong PW,Teo K

更新日期：1996-01-01 00:00:00

abstract：:To investigate the prevalence of permanent atrial fibrillation (AF), its clinical associated conditions and treatment status in the elderly population in rural Greece. 720 people (46.1% males) older than 65 years (mean age: 72.5 +/- 5.7 years) living in four villages in rural Greece were screened with an electrocardio...

journal_title：Journal of thrombosis and thrombolysis

authors： Ninios I,Bogossian H,Zarse M,Lazaridou F,Dimitriadis K,Ninios V,Lemke B,Louridas G

更新日期：2010-07-01 00:00:00

abstract：:The objective of this study were to assess the impact of a quality assurance effort on the door-to-needle time and the choice of thrombolytic agent for the management of acute myocardial infarction in the emergency department. The study design involved a prospective collection of data on a series of consecutive patien...

journal_title：Journal of thrombosis and thrombolysis

authors： Guidry UA,Paul SD,Vega J,Harris C,Chaturvedi R,O'Gara PT,Eagle KA

更新日期：1998-05-01 00:00:00

abstract：:The benefits of thrombolytic therapy in the treatment of acute myocardial infarction are incontrovertible. Large-scale studies combining angiographic and clinical end-points have demonstrated a perfusion-mortality relationship, with the highest survival rate among patients with early restoration of TIMI grade 3 corona...

journal_title：Journal of thrombosis and thrombolysis

authors： Moliterno DJ,Harrington RA,Califf RM,Rapold HJ,Topol EJ

更新日期：1995-01-01 00:00:00

abstract：:In vascular access practices, the internal vessel size is considered important, and a catheter to vessel ratio (CVR) is recommended to assist clinicians in selecting the most appropriate-sized device for the vessel. In 2016, new practice recommendations stated that the CVR can increase from 33 to 45% of the vessels di...

journal_title：Journal of thrombosis and thrombolysis

authors： Spencer TR,Mahoney KJ

更新日期：2017-11-01 00:00:00

abstract：:Thrombophilia, commonly manifested as venous thromboembolism (VTE), is a worldwide concern but little is known on its genetic epidemiology in many parts of the globe particularly in the developing countries. Here we employed TaqMan genotyping and pyrosequencing to evaluate the prevalence of known common nucleotide pol...

journal_title：Journal of thrombosis and thrombolysis

authors： Abdi AA,Osman A

更新日期：2017-11-01 00:00:00

abstract：:The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis. There is ample evidence from both laboratory and clinical studies to suggest that in addition to...

journal_title：Journal of thrombosis and thrombolysis

authors： Gorog DA

更新日期：2018-05-01 00:00:00

abstract：:Tenecteplase, a mutant form of alteplase, possesses pharmacological properties that might favor its use for emergent fibrinolysis of acute pulmonary embolism. Contemporaneous search of the World's literature reveals 14 humans with acute pulmonary embolism treated with tenecteplase. Here, we summarize those cases and r...

journal_title：Journal of thrombosis and thrombolysis

authors： Kline JA,Hernandez-Nino J,Jones AE

更新日期：2007-04-01 00:00:00

abstract：:Dual antiplatelet therapy with aspirin and clopidogrel are recommended as adjuncts to fibrinolytic-treated patients with ST-elevation myocardial infarction (STEMI). However, the role of switching to ticagrelor within 24 h of fibrinolytics compared with clopidogrel continuation in this setting is uncertain. Hence, we c...

journal_title：Journal of thrombosis and thrombolysis

authors： Kheiri B,Osman M,Abdalla A,Haykal T,Barbarawi M,Zayed Y,Hicks M,Ahmed S,Bachuwa G,Hassan M,Bhatt DL

更新日期：2018-10-01 00:00:00

abstract：:External validation is a prerequisite in order for a prediction model to be introduced into clinical practice. Nonetheless, methodologically intact external validation studies are a scarce finding. Utilization of big datasets can help overcome several causes of methodological failure. However, transparent reporting is...

journal_title：Journal of thrombosis and thrombolysis

authors： Nikolakopoulos I,Nourabadi S,Eldredge JB,Anand L,Zhang M,Qiu M,Rosenberg D,Spyropoulos AC

更新日期：2021-01-01 00:00:00

abstract：:Coagulation dysfunction and inflammatory status were compared between diabetic and non-diabetic COVID-19 patients. The standardized mean difference (SMD) and its 95% confidence interval (CI) was computed for the difference of inflammatory and hypercoagulability markers. The levels of serum ferritin (standardized mean ...

journal_title：Journal of thrombosis and thrombolysis

authors： Varikasuvu SR,Varshney S,Dutt N

更新日期：2020-09-05 00:00:00

abstract：:Monocytes and monocyte-derived microparticles (MMPs) play a major role in acute coronary syndrome (ASC). Activated monocytes (ac-M) and MMPs support thrombin generation via tissue factor (TF). The aim of this study was to evaluate the inhibitory effect of fondaparinux, a selective Xa inhibitor, on thrombin generation ...

journal_title：Journal of thrombosis and thrombolysis

authors： Ben-Hadj-Khalifa-Kechiche S,Hezard N,Poitevin S,Remy MG,Florent B,Mahjoub T,Nguyen P

更新日期：2010-11-01 00:00:00

abstract：:To assess the effect of cessation of dual antiplatelet therapy (DAPT) regimens containing 2nd generation P2Y12 inhibitors on platelet reactivity, in patients who completed 12 months of DAPT following an acute myocardial infarction. Clinical data has shown an increased cardiovascular risk in the 90 days following cessa...

journal_title：Journal of thrombosis and thrombolysis

authors： Witberg G,Bathish J,Bental T,Leshem-Lev D,Assali A,Kornowski R,Lev E

更新日期：2018-10-01 00:00:00

abstract：:The occurrence of an inhibitor against coagulation factor V (FV) is a rare but challenging condition, which may span from asymptomatic laboratory abnormalities to potentially life-threatening bleeding. The onset of FV inhibitors has been associated most frequently in the past with the patients' exposure to topical bov...

journal_title：Journal of thrombosis and thrombolysis

authors： Franchini M,Lippi G

更新日期：2011-05-01 00:00:00

abstract：:Plasminogen plays an important role in fibrinolysis as well as wound healing, cell migration, tissue modeling and angiogenesis. Congenital plasminogen deficiency is a rare autosomal recessive disorder that leads to the development of thick, wood-like pseudomembranes on mucosal surfaces, mostly seen in conjunctivas nam...

journal_title：Journal of thrombosis and thrombolysis

authors： Celkan T

更新日期：2017-01-01 00:00:00