Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA.

Abstract:

:HIV-1 trans-activator of transcription (Tat) is an unusual transcriptional activator in being an RNA-binding protein rather than a DNA-binding protein. Recent findings have greatly advanced our understanding of the transcriptional function(s) of this protein. Here we review how Tat interacts with trans-activation responsive RNA and how this interaction contributes to transcription. We discuss the biological implications of recent studies showing an association of Tat with cellular kinases(s) and protein acetylases. Evidence for nontranscriptional activities of the Tat protein is also summarized.

journal_name

Arch Biochem Biophys

authors

Rana TM,Jeang KT

doi

10.1006/abbi.1999.1206

subject

Has Abstract

pub_date

1999-05-15 00:00:00

pages

175-85

issue

2

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(99)91206-7

journal_volume

365

pub_type

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