Substrate, product, and cofactor: The extraordinarily flexible relationship between the CDE superfamily and heme.

Abstract:

:PFam Clan 0032, also known as the CDE superfamily, is a diverse group of at least 20 protein families sharing a common α,β-barrel domain. Of these, six different groups bind heme inside the barrel's interior, using it alternately as a cofactor, substrate, or product. Focusing on these six, an integrated picture of structure, sequence, taxonomy, and mechanism is presented here, detailing how a single structural motif might be able to mediate such an array of functions with one of nature's most important small molecules.

journal_name

Arch Biochem Biophys

authors

Celis AI,DuBois JL

doi

10.1016/j.abb.2015.03.004

subject

Has Abstract

pub_date

2015-05-15 00:00:00

pages

3-17

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(15)00120-4

journal_volume

574

pub_type

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