[Biochemical markers of bone turnover : clinical usefulness in osteoporosis].

Abstract:

:The recent development of specific and sensitive biochemical markers reflecting the overall rate of bone formation and bone resorption, has markedly improved the non invasive assessment of bone turnover in various metabolic bone diseases, especially for osteoporosis. The immunoassay of human osteocalcin recognizing the intact molecule and its major proteolytic fragment, assays for bone alkaline phosphatase and the intact form of the N-terminal extension propeptide of type I collagen are currently the most sensitive markers to assess bone formation. The best indices of bone resorption are the new immunoassays for the pyridinoline crosslinks and type I collagen related peptides in urine, but also very recently available in serum. Using these new markers, several studies have shown that bone turnover increases markedly after the menopause and remains elevated in late postmenopausal and elderly women. An increased bone turnover rate is related to a fast rate of bone loss in postmenopausal women and to a decreased bone mass in elderly women. Recent data suggest that some of the new immunoassays for pyridinoline crosslinks and related peptides could predict the subsequent risk of hip fracture in elderly women. Thus, bone markers might be used in combination with bone mass measurement to improve the prognostic assessment of postmenopausal women, i.e. their risk of developing osteoporosis and ultimately fractures. Treatment of postmenopausal women with antiresorptive drugs such as estrogens, bisphosphonates and calcitonin is followed by rapid decrease of the levels of bone markers that is correlated with the long term increase of bone mass as assessed by dual-energy X ray absorptiometry measurement. Thus, bone markers should be useful in monitoring treatment efficacy in patients with osteoporosis. Appropriate combination of the most efficient markers of bone formation and resorption will probably provide a powerful tool in the clinical investigation of osteoporosis.

journal_name

Ann Biol Clin (Paris)

authors

Garnero P,Delmas PD

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

137-48

issue

2

eissn

0003-3898

issn

1950-6112

journal_volume

57

pub_type

杂志文章,评审
  • Is a pre-analytical process for urinalysis required?

    abstract::For the reliable urinary measurement of calcium, phosphate and uric acid, a pre-analytical process by adding acid or base to urine samples at laboratory is recommended in order to dissolve precipitated solutes. Several studies on different kind of samples and analysers have previously shown that a such pre-analytical ...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:10.1684/abc.2017.1271

    authors: Petit M,Beaudeux JL,Majoux S,Hennequin C

    更新日期:2017-10-01 00:00:00

  • [Practical aspects of leukotriene E4 determination in urine].

    abstract::Leukotrienes constitute a class of potent biological mediators of inflammation and anaphylaxis. However, their routine assay in various biological fluids is restricted by the complexity of the methodology. Previously this could only be performed by research laboratories with high pressure liquid chromatography and rad...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:

    authors: Chabane MH,Le Vraux V,Le Provost AM,Leynadier F

    更新日期:1995-01-01 00:00:00

  • [Genetic aspects of atherogenic dyslipoproteinemias].

    abstract::Beyond persistent underestimation of atherogenic dyslipoproteinemias of genetic origin, which account altogether for one out of 50 births, and even more, considerable advances have been done, in the last past years, about molecular and genetic basis of metabolic defects, and possible various mutations--at this level. ...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:

    authors: de Gennes JL

    更新日期:1986-01-01 00:00:00

  • Some advances in the field of physico-chemical characterization of pathological microcrystals.

    abstract::Recent advances in the characterization of microcrystals in tissue samples based on physico-chemical techniques are reviewed. It is a new opportunity for the physician to access early a diagnosis of rare but severe pathologies and to start a specific therapy able to delay or to stop an irreversible alteration of the o...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:10.1684/abc.2015.1070

    authors: Bazin D,Daudon M

    更新日期:2015-09-01 00:00:00

  • [Effect of physical activity on bone turnover in young boys].

    abstract:AIMS:To evaluate the effect of the physical activity on bone turnover in young male soccer players at the Tanner's stage of 1-2. MATERIAL AND METHODS:61 young soccer players (13,4 +/- 0,3 years old) who actively participated in soccer since 3,7 +/- 0,7 years were compared to 60 age and sex- matched non active subjects...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:

    authors: Kalaï E,Bahlous A,Nbigh A,Sahli H,Sellami S,Abdelmoula J

    更新日期:2007-09-01 00:00:00

  • [Method validation according to ISO 15189 and SH GTA 04: application for the extraction of DNA and its quantitative evaluation by a spectrophotometric assay].

    abstract::According to the French legislation on medical biology (January 16th, 2010), all biological laboratories must be accredited according to ISO 15189 for at least 50% of their activities before the end of 2016. The extraction of DNA from a sample of interest, whether solid or liquid is one of the critical steps in molecu...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:10.1684/abc.2013.0891

    authors: Harlé A,Lion M,Husson M,Dubois C,Merlin JL

    更新日期:2013-09-01 00:00:00

  • [B-cell non-Hodgkin lymphoma discovery after observation of a platelet satellitism around atypical lymphocytes].

    abstract::We report the case of an 83-year-old woman admitted to the accident and emergency unit for pneumopathy. The blood cell count on the DXH automaton (Coulter® ™ UniCel® DxH) found a normochromic and normocytic anemia, anormal platelet count and subnormal leukocyte formula. The only alarm raised by the automaton was the p...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:10.1684/abc.2018.1406

    authors: Gatignol A,Amirault M,Legac É,Decker J

    更新日期:2019-04-01 00:00:00

  • [Biology and potential of human embryonic stem cells].

    abstract::Human embryonic stem cells (hESC) are obtained from the inner cell mass from the early embryo at blastocyste stage. Derived in cell lines for the first time in 1998, they can be maintained in culture in an undifferentiated state indefinitely under certain conditions. Two essential properties characterize hESC: pluripo...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章,评审

    doi:10.1684/abc.2008.0224

    authors: Tondeur S,Assou S,Nadal L,Hamamah S,De Vos J

    更新日期:2008-05-01 00:00:00

  • [Prescribing guidance pocket chart on the initiation of warfarin therapy in a geriatric hospital: a useful but challenging tool].

    abstract::Elderly patients are at high risk of over-anticoagulation and of haemorrhagic risk when on warfarin, especially during treatment induction. In Charles Foix Hospital, a 800-bed geriatric hospital, we specifically developed for in-patients older than 70 years (target INR 2.5) a simple low-dose warfarin induction regimen...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:

    authors: Siguret V,N'Guyen A,Harboun M,Chevallier A,Pautas E,Gouin-Thibault I,Berigaud S

    更新日期:2006-05-01 00:00:00

  • [Adaptation to Gemsaec centrigugal analyser of a method of turbidimetric estimation of amylase (author's transl)].

    abstract::Hydrolysis of a solution of amylopectin by serum or urinary amylase leads to a reduction of the turbidity of this solution, observed at 340 nm. Adapted to centrifugal analysis, this method permits 15 estimations in 3 minutes with a serial reproducibility of 2.7 per cent, and a daily reproducibility of 6 per cent. The ...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:

    authors: Houdret N,Porchet N,Lebas J,Douche MA,Degand P,Roussel P

    更新日期:1979-01-01 00:00:00

  • Droplet digital PCR, a new approach to analyze fetal DNA from maternal blood: application to the determination of fetal RHD genotype.

    abstract::The discovery of free fetal DNA in the maternal circulation has inaugurated the era of non-invasive prenatal diagnosis. The latter has the advantage of avoiding the use of conventional obstetric procedures, such as chorionic villus sampling or aspiration of amniotic fluid, thus limiting the risks of miscarriage they i...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:10.1684/abc.2016.1139

    authors: Orhant L,Rondeau S,Vasson A,Anselem O,Goffinet F,Allach El Khattabi L,Leturcq F,Vidaud D,Bienvenu T,Tsatsaris V,Nectoux J

    更新日期:2016-06-01 00:00:00

  • [Interest of the combination of high-sensitivity troponine and copeptin in diagnosis of non ST elevation myocardial infarction].

    abstract::The diagnosis of non ST elevation myocardial infarction (NSTEMI) is very important for the emergency doctor. According to the literature copeptin, a marker of the endogenous stress, combined with troponin could be of interest in this diagnosis. The objective of the study was to investigate the association of high-sens...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:10.1684/abc.2013.0884

    authors: Bourgeois C,Douplat M,Guieu R,Pradel V,Fromonot J,Bonnet JL,Alazia M

    更新日期:2013-09-01 00:00:00

  • [Spermatozoon search in forensic medicine].

    abstract::The search for sperm is part of the examinations wich may be prescribed, following a request of jucicial services, in case of a suspicion of sexual assault. This article applies to detail how the different phases, pre-analytical, analytical and post-analytical, must be absolutely adhered to so that the biologist, expe...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:10.1684/abc.2008.0274

    authors: Laudat A,Lecourbe K

    更新日期:2008-09-01 00:00:00

  • [Genetic diseases of erythrocyte membrane permeability].

    abstract::A group of genetic disorders of the red cell, appearing as congenital haemolytic anaemias, were first described on morphological bases, due mainly to the presence of stomatocytes. It turned out, however, that the alterations of the shape could widely vary, and even be absent, thereby questionning the classification on...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章,评审

    doi:

    authors: Delaunay J

    更新日期:1999-07-01 00:00:00

  • [Assay of sex hormone-binding globulin (SHBG) in human serum. Comparative measurements using three methods].

    abstract::Determination of sex-hormone-binding-globulin was performed by three methods: binding, electroimmunodiffusion and DELFIA methods. Results of normal and pathological values correlated well with the three techniques. ...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:

    authors: Patricot MC,Mathian B,Later F,Revol A

    更新日期:1990-01-01 00:00:00

  • Sites internet

    abstract::http://biotribune.com/ Biotribune.com ou la biologie medicale sur internet. Ce site est concu comme un portail sur la biologie clinique. Accueil d'internautes sur une page comportant, entre autres, les rubriques : actualite, evenements, revue des connaissances, rubrique juridique et petites annonces. Biotribune propos...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:

    authors: Couderc R

    更新日期:2000-07-01 00:00:00

  • [Pharmacogenetics or the promise of a personalized medicine: variability in drug metabolism and transport].

    abstract::There is much variability in the manner individuals respond to drugs, such that the management of some drugs is problematic. In France, the incidence of hospital admissions related to adverse drug reactions is estimated to be 3.2 %, at an annual cost of over 300 millions euros. Genetic factors affecting the pharmacoki...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章,评审

    doi:

    authors: Allorge D,Loriot MA

    更新日期:2004-09-01 00:00:00

  • [Etiology and diagnostic of viral bronchopneumonias].

    abstract::Community viral bronchopneumonias are frequent, mainly in children, and can be associated to all respiratory viruses: influenza- and parainfluenzavirus, respiratory syncytial virus, adenovirus, rhinovirus. The diagnostic method which proves viral infection of the respiratory tissues is selected as the direct detection...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章,评审

    doi:

    authors: Freymuth F,Vabret A,Galateau F,Brouard J,Eugene G,Petitjean J,Gennetay E

    更新日期:1998-01-01 00:00:00

  • [Genetic causes of male infertility].

    abstract::In this review, after a brief summary of the spermatogenesis process, we present some genetic causes of male infertility at chromosome and gene level, known at present. Even though knowledge has greatly increased, in 15% of cases, we still do not know the infertility mechanism. The genotype-phenotype relationship rema...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章,评审

    doi:

    authors: Seifer I,Fellous M,Bignon Y

    更新日期:1999-05-01 00:00:00

  • [Rapid preparation of ornithine carbamyl transferase without carbamyl phosphate synthetase activity (author's transl)].

    abstract::A rapid method of preparation of ornithine carbamyl transferase from rat liver is described. The enzyme preparation obtained is lacking in carbamyl phosphate synthetase activity. It may thus be used for the estimation of this enzyme on liver fragments obtained by needle biopsy of the liver in the diagnosis of neonatal...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:

    authors: Rabier D,Cathelineau L,Kamoun P

    更新日期:1978-01-01 00:00:00

  • [New bacteriologic aspects in infectious pathology].

    abstract::Bacterial infectious pathology presents a series of new features which have been elucidated over the last few decades. These new aspects are derived from various factors: a development of our state of knowledge, a change in the ecology of a number of bacteria and a change in the receptiveness of patients. Modern infec...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:

    authors: Wauters G

    更新日期:1983-01-01 00:00:00

  • [Complications of infected aneurysm due to Salmonella enteritidis: a case report].

    abstract::Salmonelloses are becoming more frequented. To date, very few cases of aneurisms or vascular grafts infections have been described. We report the rare case of an extradigestive manifestation, due to Salmonella enteritidis affecting a patient with Behçet disease. The biological diagnosis is based on microorganism isola...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:10.1684/abc.2010.0405

    authors: Oudaïna W,Rhissassi B,Lagmouchi M,Aboulmakarim S,Bensaid Y,Zouhdi M

    更新日期:2010-01-01 00:00:00

  • [Identification of HLA B27 antigen by flow cytometry].

    abstract::Cytofluorograph analysis after immunofluorescence with monoclonal antibodies can be useful for various antigens identification on the surface of cell membrane. This technic is described for antigen HLA B27 identification. This HLA antigen is known indeed to be linked to rhumatismal diseases. The fluorescence histogram...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:

    authors: Fizet D,Hitte C,Ferrer AM,Vezon G

    更新日期:1989-01-01 00:00:00

  • [Determination of glutathione with the GSH-400 method: value of derivative spectrophotometry].

    abstract::The GSH-400 method (Oxis International SA) performed in acid supernatant, provides an assay of reduced glutathione (L-gamma-glutamyl-L-cysteinylglycine) (GSH) in biological samples by a two step chemical reaction followed by a spectrophotometric detection. We improved the analytical performances of the assay by using ...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:

    authors: Boutolleau D,Lefévre G,Etienne J

    更新日期:1997-11-01 00:00:00

  • [Neonatal screening of glucose-6-phosphate dehydrogenase deficiency in umbilical cord blood].

    abstract::Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most frequent enzyme deficiency. It is a sex-linked genetic disease concerning mostly african, mediterranean and far-eastern populations. The main clinical expression is a hemolytic anemia which can be acute or chronic. During the neonatal period the disease m...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:

    authors: Kaddari F,Sawadogo M,Sancho J,Lelong M,Jaby D,Paulin C,Nkana K,Cailliez M

    更新日期:2004-07-01 00:00:00

  • [Pulmonary mycoses and parasitosis].

    abstract::Lungs can be the target of many fungal parasitic organisms. Some of them are specific to the lung (Pneumocystis); while others will migrate there in the course of their life cycle (Ascaris) or be caught in it (Paragonimus, Echinococcus). Sometimes, they also generate hypersensitivity reactions (fungi). In making a dia...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章,评审

    doi:

    authors: De Gentile L,Chabasse D

    更新日期:1990-01-01 00:00:00

  • [Therapeutic monitoring of antidepressant drugs].

    abstract::Depression is a pathology frequently observed in general medicine (10%). Treatment of depression makes great use of drugs from different pharmacological classes. The optimal posology is difficult to establish, and clinicians prefer to avoid side effects by prescribing low regimen. This study is related to an evaluatio...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:

    authors: Charlier C,Ansseau M,Pinto E,Andrien F,Plomteux G

    更新日期:1999-07-01 00:00:00

  • Protective effect of ginger against toxicity induced by chromate in rats.

    abstract::The evaluation of the effect of ginger on the modulation of toxic effects induced by chromate is the objective of our study. 50 male rats Albinos Wistar were divided to five groups as follow: group I (T) is served as control, received a mineral water by gavage (per os); group II (G) received an experimental diet with ...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:10.1684/abc.2013.0806

    authors: Krim M,Messaadia A,Maidi I,Aouacheri O,Saka S

    更新日期:2013-03-01 00:00:00

  • Lysosomal storage diseases: cellular pathology, clinical and genetic heterogeneity, therapy.

    abstract::Lysosomal storage diseases are genetically determined metabolic diseases characterized by dysmorphology and dysfunction of the lysosomal system. The lysosomal pathology can have different causes; these are (i) the deficiency of a lysosomal enzyme or subunit thereof, (ii) the deficiency of a protein assisting one or mo...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章,评审

    doi:

    authors: Reuser AJ,Kroos MA,Visser WJ,Willemsen R

    更新日期:1994-01-01 00:00:00

  • [The diagnosis of a group of Streptococci. 1 - Comparative study of various techniques for the extraction of the polyoside antigen from Streptococci].

    abstract::The present importance of streptococcal pathology implicates the identification of the streptococcal groups. The authors have carried out a comparative study of the various methods of extraction of the group specific antigen. They demonstrated the advantages and disadvantages of each method and consider the pronase ex...

    journal_title:Annales de biologie clinique

    pub_type: 杂志文章

    doi:

    authors: Bergogne-Berezin E,Slim A

    更新日期:1976-01-01 00:00:00