Abstract:
:The antithrombotic effect of three different types of antithrombotic agents (antithrombin:argatroban, heparin, defibrinogenating agent:batroxobin) were evaluated in canine coronary and iliac arteries. An occlusive thrombus was produced by balloon injury. One of the three agents was infused intravenously at 1 hour after thrombus formation (heparin 250 U/kg, argatroban 0.5 mg/kg, batroxobin 0.5 U/kg) and the effect of thrombus size reduction was evaluated. On the contralateral side of the iliac artery, the preventive effect of these agents on thrombus formation was evaluated after balloon injury. In the iliac artery, angioscopic percent area obstruction by the thrombus before and 60 minutes after treatment reduced from 69% to 32% in the argatroban group, and from 64% to 51% in the batroxobin group (P < 0.0001 and P < 0.05, respectively). No significant change was observed in the heparin group. Angiography demonstrated the same trend. The percent area stenosis with thrombus at 60 minutes following balloon injury was 0.75% in the argatroban group, 18.9% in the heparin group (P < 0.05 vs argatroban), and 12.9% in the batroxobin group. Thrombus size at the treated site was smaller than that at the control site in all three groups (P < 0.05 vs control). In the coronary artery, angioscopic percent area obstruction by the thrombus before and 60 minutes after treatment reduced from 84% to 53% in the argatroban group, and from 86% to 68% in the batroxobin group (P < 0.0001 and P < 0.05, respectively). No significant change was observed in the heparin group. Angiography also demonstrated the same trend. The activated partial thromboplastin time (APTT) was prolonged to 189% of the control value with argatroban and to 1253% of the value with heparin (P < 0.0001). Fibrinogen was markedly reduced with batroxobin. These results showed that both the antithrombin agent and the defibrinogenating agent have a preventive effect on thrombus formation and the effect on thrombus size reduction, without marked prolongation of the APTT.
journal_name
J Interv Cardioljournal_title
Journal of interventional cardiologyauthors
Tomaru T,Nakamura F,Miwa AY,Fujimori Y,Omata M,Okada R,Uchida Ydoi
10.1111/j.1540-8183.1994.tb00478.xsubject
Has Abstractpub_date
1994-10-01 00:00:00pages
409-19issue
5eissn
0896-4327issn
1540-8183journal_volume
7pub_type
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journal_title:Journal of interventional cardiology
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abstract::Eighty-three consecutive patients with 85 coronary total occlusions undergoing coronary angioplasty were retrospectively studied. Patients were divided into two groups according to the occlusion age that was < 30 days (subacute total occlusion [STO]: 25 patients; range 1-30 days) or > 30 days (chronic total occlusion ...
journal_title:Journal of interventional cardiology
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更新日期:2002-06-01 00:00:00
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journal_title:Journal of interventional cardiology
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2006.00129.x
更新日期:2006-04-01 00:00:00
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journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2007.00301.x
更新日期:2007-12-01 00:00:00
abstract:INTRODUCTION:Current guidelines recommend coronary artery bypass grafting (CABG) for patients with multivessel coronary disease and left ventricular (LV) dysfunction. However, some patients undergo percutaneous coronary intervention (PCI) or solely medical therapy (MT) in actual practice. The comparison of long-term ou...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/joic.12497
更新日期:2018-06-01 00:00:00
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journal_title:Journal of interventional cardiology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-06-01 00:00:00
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journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1155/2020/5036396
更新日期:2020-07-09 00:00:00
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journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2009.00446.x
更新日期:2009-06-01 00:00:00
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journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2012.00693.x
更新日期:2012-08-01 00:00:00
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journal_title:Journal of interventional cardiology
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journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/joic.12266
更新日期:2016-02-01 00:00:00
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journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2010.00593.x
更新日期:2011-02-01 00:00:00
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journal_title:Journal of interventional cardiology
pub_type: 杂志文章
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更新日期:2020-05-11 00:00:00
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journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2011.00654.x
更新日期:2011-10-01 00:00:00
abstract::Paravalvular leaks are a recognized complication of valve replacement surgery. We report a 47-year-old man with left atrial isomerism, interrupted left sided inferior caval vein with unilateral left sided superior caval vein, a common atrium, and anomalous pulmonary venous connection to the coronary sinus, who had rec...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/j.1540-8183.2007.00290.x
更新日期:2007-12-01 00:00:00
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journal_title:Journal of interventional cardiology
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更新日期:2010-06-01 00:00:00
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journal_title:Journal of interventional cardiology
pub_type: 杂志文章
doi:10.1111/joic.12568
更新日期:2018-12-01 00:00:00
abstract::Chronic total occlusion (CTO) is a frequent finding in patients with coronary artery disease and when clinically indicated, remains one of the most challenging subsets for intervention. Although successful recanalization rates of CTO have remained suboptimal in percutaneous coronary intervention, evolving techniques i...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,评审
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更新日期:2016-02-01 00:00:00
abstract:AIM:Over the past 2 decades, transcatheter occlusion of patent ductus arteriosus (PDA) with coils and the duct occluders evolved to be the procedure of choice. A new device, the Occlutech PDA® occluder (ODO) device has been designed. Herein, we aimed to evaluate the characteristics and short-term results of patients wh...
journal_title:Journal of interventional cardiology
pub_type: 杂志文章,多中心研究
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