Abstract:
OBJECTIVE:Cellular adhesion molecules ICAM-1 and VCAM-1 have been implicated in tumor progression and metastasis. As the sequential interaction of neoplastic cells with the endothelium of tumor neovascularisation is believed to be essential for tumor metastasizing processes, we analysed the concentration of ICAM-1 and VCAM-1 in the cytosol of patients with human breast cancers and their corresponding sera. We compared the obtained values with established prognostic parameters for breast cancer. Benign breast tissues were also analyzed. PATIENTS AND METHODS:Levels of ICAM-1 and VCAM-1 of 62 patients with invasive breast cancer and 17 patients with benign breast tissue were measured using commercially available sandwich enzyme-linked immunoassays with monoclonal antibodies. To establish a reference and control group, levels of ICAM-1 and VCAM-1 were measured in the sera of 66 women without breast tumors. RESULTS:The mean cytosol concentration of ICAM-1 and VCAM-1 was significantly higher in the breast cancer specimens than in the tissue of patients with benign breast diseases. This could be found not only in the tumor cytosol but also in the corresponding sera of the patients. No correlations between the ICAM-1 and VCAM-1 expressions and established prognostic parameters could be observed. CONCLUSIONS:Our findings suggest that malignant breast cancer cells could induce neovascularisation with subsequent high expressions of ICAM-1 and VCAM-1. These upregulations of adhesion molecules might contribute to changes in invasive phenotypes by promoting endothelial cell adhesion and angiogenesis, as well as being responsible for the recognition of tumor cells by the human immune system. Prognostic relevance for the development of breast cancer could not be established.
journal_name
Eur J Gynaecol Oncoljournal_title
European journal of gynaecological oncologyauthors
Regidor PA,Callies R,Regidor M,Schindler AEsubject
Has Abstractpub_date
1998-01-01 00:00:00pages
377-83issue
4eissn
0392-2936issn
2709-0086journal_volume
19pub_type
杂志文章abstract::A case of secretory (juvenile) carcinoma of the breast is reported in a 31-year-old woman. Secretory carcinoma in adults is rare, only twenty-seven cases previously reported. It is known to have a more favourable prognosis than the conventional ductal carcinoma. The most adequate treatment appears to be a simple maste...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::To investigate the influence of tamoxifen, danazol and triptorelin (a GnRH agonist) on estrogen and progesterone receptors of rat endometrium, 44 castrated Sprague-Dawley rats were divided into four equal groups, and each group received either no treatment or one of the agents. After administration of the agents, estr...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Peritoneal cytology, obtained at the start of planned radical hysterectomy in 200 consecutive patients with Stage IB cervical cancer, none of whom had intra-abdominal extension of disease, was positive in only one patient; this patient received no adjuvant treatment and remains disease-free at 48 months. Routine perit...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:AIM:The aim of this study was to determine the diagnostic value of thrombocytosis and high CA 125 levels in women with benign and malign adnexal masses. Thrombocytosis (platelet counts > 400 x 10(9)/l) has been identified as a poor prognostic factor in many cancers including certain gynecologic malignant tumors such as...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::Malignant mesothelioma of the peritoneum is a rare tumor that must be distinguished from the more common primary peritoneal serous epithelial neoplasms. We report a case of a 66-year-old female presenting with weight loss, anemia, and a large pelvic mass on ultrasound. At laparotomy a large (9 x 6.5 x 3.5 cm) mass in ...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::The influence of various CO2 laser surgical techniques on tumor behaviour was examined in an experimental model on C56BL/6 mice (n = 106) with Lewis Lung carcinomas and compared with that of scalpel excised tumors. Comparisons were made between the healing procedure, the local recurrence rate, metastatic behaviour and...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::A case of a 31-year-old patient admitted to the Institute with a diagnosis of recurrent cervical cancer after radical hysterectomy and radiation therapy 12 months before. The patient had intestinal and urinary obstruction and also the tumor compressed the iliac blood vessels superficially. She underwent clinical exami...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to collect data about the incidence of high-risk HPV (16, 18, 33) types in in situ cervical cancers, and to evaluate the reliability of the morphological signs of HPV infection by comparing the presence of these signs to the PCR-proven HPV virus infection. METHODS:Fifty patients...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::From 1985 to 1990, 3040 patients with carcinoma of the uterine cervix were diagnosed and treated at Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Thailand. The epidemiological aspects including ages and geographical distributions, histology, stages, treatment and outcome were presented and compared ...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:Differences of the clinical features of Stage I borderline ovarian tumors and Stage I ovarian cancer need to be clarified. METHODS:We retrospectively investigated 215 patients with Stage I ovarian tumors (67 with borderline tumors and 148 with ovarian cancer) treated between 1988 and 2001. RESULTS:Only one pa...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To assess the relation between expressions of human nonmetastatic clone 23 (nm23-H1) and p53 in cervical cancer, their relationships with lymph node metastasis, and further to examine their predictive of lymph node metastases. MATERIALS AND METHODS:nm23-H1 and p53 expression profiles were visualized by immun...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::This paper reports the results of a study of 50 menopausal women receiving hormonal replacement therapy. The majority (29) had surgical menopause; their mean age was 45.7 years. It was hypothesized that progestins could equilibrate the effects of the estrogenic stimulation on the mammary and endometrial target tissu...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:To determine if there are founder BRCA1 mutations in the Mongolian population. METHODS:Seventeen women with ovarian cancer, 14 women with premenopausal breast cancer and one woman with both cancer types were interviewed to obtain family history, and hormonal, reproductive and environment risk factor informat...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::The sentinel node procedure has increasingly been used as a diagnostic tool for staging breast cancer. Although many institutes have embraced this procedure, many issues concerning the indications and the technique itself remain unsolved. In this review, several aspects regarding these controversies are discussed from...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:The objective of this work was to assess proper management of squamous intraepithelial lesion (SIL) and microinvasive carcinoma during and after pregnancy, to assess risks of punch biopsy and conization in pregnancy and to assess regression, persistence and risk of progression with low-grade (L) and high-grad...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::This paper reports an investigation of the mechanism involved in the response of endometrial adenocarcinoma to MPA. The following protocol was used for a period of 8 years: 1 g/day MPA per os for 30 days and 60 days after surgery, following by 500 mg/day for 1 year. Adenocarcinoma glycolytic activity, G-6-P cycle, pol...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::A 35-year-old woman presented with an adnexal mass which came out as a leiomyosarcoma of the broad ligament arising in a pre-existing pure neurilemmoma-like leiomyoma. This is the first reported case of leiomyosarcoma arising in a pure neurilemmoma-like leiomyoma, the third reported case at an unusually young age show...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::The objective of this study was to review studies that have investigated the immune response in the presence of a malignant ovarian neoplasia. A review of the literature was performed to identify studies of malignant ovarian neoplasia, particularly studies that addressed the potential for cytokines, nitric oxide, and ...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
doi:
更新日期:2014-01-01 00:00:00
abstract::Cancer of the endometrium is a neoplasm which essentially strikes postmenopausal women and in which the predominant risk factors are recognized as an excessive imbalance of estrogen and obesity. The survival rate is good in the first stage and is acceptable in the second, while in the third and especially the fourth s...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract:PURPOSE OF INVESTIGATION:Neuroendocrine small cell carcinoma of the uterine cervix (NESCC) grows aggressively, and is resistant to anticancer agents and radiation, having an extremely poor prognosis. The incidence of c-kit proto-oncogene overexpression is high in gastrointestinal stromal tumors (GISTs) and small cell l...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Colorectal cancers are rare during pregnancy and the management is controversial and challenging. Prognosis is usually unfavorable due to late diagnosis since the presenting symptoms of colorectal cancer are attributable to the usual manifestations of pregnancy. Management depends on the patient's age and desire for f...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::Recent reports suggest an increased incidence of endometrial cancer in breast cancer patients under long-term adjuvant tamoxifen (TAM) treatment. The Authors describe two cases of endometrial adenocarcinoma among 80 post-menopausal patients affected with breast cancer and treated with TAM. ...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
doi:
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:The aim of the pilot study was to assess the feasibility, efficacy, and accuracy of the sentinel lymph node biopsy (SLNB) procedure in vulvar cancer. PATIENTS AND METHODS:From February 2003 to March 2007, 17 patients with vulvar cancer, clinical Stages I and II, underwent SLN (sentinel lymph node) detection...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Oncological internet information quality is considered variable, but no comprehensive analysis of gynecological malig- nancies exists. The present authors' objectives were to compare the quality of common malignancy websites and to assess for language or disease differences; and secondly, to perform a qualit...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2016-08-01 00:00:00
abstract::Ductal carcinoma in situ (DCIS) represents a biologically and morphologically heterogeneous disease. It is characterized by a proliferation of presumably epithelial malignant cells confined within the lumens of the mammary ducts, without evidence of invasion beyond the basement membrane into the adjacent breast stroma...
journal_title:European journal of gynaecological oncology
pub_type: 历史文章,杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::A para 1, 52-year-old female was admitted with complaints of irregular vaginal bleeding for the previous six months. Ultrasonography revealed a 4x6-cm tumor extending into the uterine cavity and cervical canal. On vaginal examination, a 2x2-cm tumor protruding from the cervical os was found, and an enlarged uterus was...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
doi:
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Some Japanese institutes have been performing a population screening program for cervix cancer involving the simultaneous use of Pap smear and colposcopy. This program may be a good model for evaluating the efficacy of Pap smears and colposcopy. METHODS & MATERIALS:The subjects included 2,000 women who under...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Malignant mixed müllerian tumour of the fallopian tube is an extremely rare lesion and to date only approximately 50 cases have been reported. The tumour is seldom distinguished preoperatively from other more common lesions or ovarian cancer. We report a case of a 60-year-old woman who presented to our hospital with p...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to determine whether phosphorylation of histone H2AX (γH2AX) is a predictive marker for neoadjuvant chemotherapy patients of cervical cancer. MATERIALS AND METHODS:The sections were divided into three sets. Set 1 consisted of 40 pre-treatment biopsies. Post-treatment tissues includes 38 pati...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
abstract::Ovarian yolk sac tumor (YST) is a malignant ovarian neoplasm differentiated from primordial germ cells that occur in young age, while endometrioid carcinoma (ECA) is a müllerian epithelial tumor that usually occurs in older patients. The coexistence of an ovarian ECA and YST component is very rare. Only 12 cases have ...
journal_title:European journal of gynaecological oncology
pub_type: 杂志文章,评审
doi:
更新日期:2010-01-01 00:00:00