Abstract：
:Headaches appear to be a reaction to changes in either exogenous levels. We are now investigating serum immunoglobulins in women with menstrual migraine and have found that in 22 women, 6 have low immunoglobulin A levels, all below the normal range, and 5 have high immunoglobulin M levels, above the normal range. The hereditary aspect of migraine may depend on inheriting a particular immune pattern which might cause a special sensitivity to hormone effects on blood vessels. This might account for the suppression of menstrual migraine by cortisone or large doses of progesterone. Deficiency of progesterone is unlikely to be responsible for the premenstrual syndrome as the week following menstruation is usually the time which is most often free from symptoms and at this part of the cycle there are very low levels of progesterone. The most reactive women are also the most sensitive to the side effects of drugs or hormones given to treat migraine, which makes the treatment of migraine difficult.
journal_name
Minerva Medjournal_title
Minerva medicaauthors
Grant EC,Pryse-Davies J,Goodwin PM,Caroll JDsubject
Has Abstractpub_date
1976-06-23 00:00:00pages
2034-6issue
31eissn
0026-4806issn
1827-1669journal_volume
67pub_type
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