Abstract:
:A subset of human immunodeficiency virus (HIV)-infected patients develop persistent CD8 hyperlymphocytosis and a Sjogren's syndrome-like syndrome associated with multivisceral CD8 T-cell infiltration, known as the diffuse infiltrative lymphocytosis syndrome (DILS). Patients with DILS tend to have higher CD4 cell counts, fewer opportunistic infections, and longer survival times than other HIV-infected patients. Peripheral nerve involvement in DILS has been poorly documented. We studied 12 HIV-infected patients with CD8 hyperlymphocytosis, DILS, and clinical signs of peripheral neuropathy. Two of 4 patients who were HLA typed were HLA-DR5 and 1 was HLA-DR6. All patients had the sicca syndrome and multivisceral involvement. The neuropathy was acute or subacute, always painful, and symmetrical in 8 cases. Electrophysiology was consistent with axonal neuropathy in 10 of 12 patients. Nerve biopsy showed marked angiocentric CD8 infiltrates without mural necrosis (12 of 12), and abundant expression of HIV p24 protein in macrophages (12 of 12). The HIV genome was detected by polymerase chain reaction in nerve homogenates. Zidovudine therapy was associated with improvement in 6 of 6 patients and steroid therapy was beneficial in 4 of 5 patients. No T-cell lymphoma was observed during follow-up, but 2 patients developed a primary B-cell lymphoma. We conclude that DILS neuropathy represents HIV-associated neuropathy, characterized by marked CD8 infiltration and abundant HIV in nerve, that improves with zidovudine or steroid therapy, and probably reflects a systemic host-determined and antigen-driven response to HIV.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Moulignier A,Authier FJ,Baudrimont M,Pialoux G,Belec L,Polivka M,Clair B,Gray F,Mikol J,Gherardi RKdoi
10.1002/ana.410410406subject
Has Abstractpub_date
1997-04-01 00:00:00pages
438-45issue
4eissn
0364-5134issn
1531-8249journal_volume
41pub_type
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journal_title:Annals of neurology
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journal_title:Annals of neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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doi:10.1002/ana.410100505
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1994-11-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1990-02-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1991-08-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1981-12-01 00:00:00
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journal_title:Annals of neurology
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更新日期:2019-04-01 00:00:00
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pub_type: 临床试验,杂志文章
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