Cobalt-55 positron emission tomography in ischemic stroke.

Abstract:

:After acute cerebral stroke, the (peri-) infarct tissue is characterized by calcium (Ca)-mediated neuronal damage and inflammatory processes. Monitoring Ca-mediated damage using the isotope cobalt-55 (Co) as a Ca-tracer may enable PET-imaging of this tissue. Since the fate of (peri-) infarct tissue determines clinical outcome, Co-PET may have prognostic value in stroke. Six stroke patients were examined with Co-PET, MRI and a middle cerebral artery (mca) stroke scale (Orgogozo). In every patient, specific Co-accumulation in the appropriate brain region was seen, irrespective of the integrity of the blood-brain barrier. This pilot study suggests Co-PET as a diagnostic tool in stroke, which may provide additional information on the clinical outcome. Validation of method in larger patient series is necessary.

journal_name

Clin Neurol Neurosurg

authors

Jansen HM,Paans AM,vd Vliet AM,Veenma-van der Duin L,Bolwijn-Meijer CJ,Pruim J,Willemsen AT,Franssen EJ,Minderhoud JM,Korf J

doi

10.1016/s0303-8467(96)00558-6

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

6-10

issue

1

eissn

0303-8467

issn

1872-6968

pii

S0303846796005586

journal_volume

99

pub_type

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