Abstract:
OBJECTIVE:Gliosarcoma (GSC) is a rare histological variant of glioblastoma (GBM). Due to limited evidence regarding clinical, genetic and radiographic characteristics of GSC, this study aimed to analyze independent outcome predictors of GSC, and to address the differences between GSC and GBM concerning the baseline characteristics and patients' survival. METHODS:Patients treated between 2001 and 2018 for the diagnosis of GBM and GSC were included in this study. Patients' records were reviewed for demographic, clinical, genetic and radiographic characteristics. Univariate, multivariate and propensity score matched analyses were performed. RESULTS:In the GSC sub-cohort (N = 56), patients' age, preoperative clinical status, midline tumor location and tumor size were found to be independently associated with overall survival. As compared to GBM individuals (N = 1249), a temporal location (p = 0.002), presence of eccentric tumor cysts (p < 0.001), a higher ratio of TP53 staining (p = 0.002) and a lower ratio of GFAP staining (p = 0.005) were characteristic for GSC. The diagnosis of GSC was associated with a poorer survival (p = 0.002) independently of the patients' age, sex, clinical status and extent of resection, However, this association was no more significant, when enhancing the multivariate analysis with molecular-genetic characteristics (IDH1 mutation and MGMT promotor methylation status). DISCUSSION:Certain radiographic and molecular-genetic patterns present the distinct characteristics of GSC. There is an association between the diagnosis of GSC and a poorer outcome. This difference might be linked to different genetic alterations in GBM and GSC. Prospective studies are needed to further elucidate the characteristics of GSC and develop targeted treatment approaches for this rare variant.
journal_name
Clin Neurol Neurosurgjournal_title
Clinical neurology and neurosurgeryauthors
Pierscianek D,Ahmadipour Y,Michel A,Rauschenbach L,Darkwah Oppong M,Deuschl C,Kebir S,Wrede KH,Glas M,Stuschke M,Sure U,Jabbarli Rdoi
10.1016/j.clineuro.2020.106348subject
Has Abstractpub_date
2021-01-01 00:00:00pages
106348eissn
0303-8467issn
1872-6968pii
S0303-8467(20)30691-0journal_volume
200pub_type
杂志文章abstract::Lumbosacral plexus neuropathy (LSPN) is an idiopathic clinical syndrome characterized by the sudden onset of neuropathic pain, followed by weakness and sometimes sensory disturbances in the distribution of the lumbosacral plexus. Prognosis is usually favourable, although complete recovery may take several months to ye...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/s0303-8467(97)00603-3
更新日期:1997-05-01 00:00:00
abstract::The endoscope has traditionally been used in neurosurgery to access a lesion within a natural body cavity. The challenge has been to access and resect deep-seated intraparenchymal lesions using a minimally invasive endoscopic technique. Endoscopic endonasal trans-sphenoidal surgery has gained increasing acceptance by ...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/j.clineuro.2018.05.009
更新日期:2018-07-01 00:00:00
abstract::Syncope is a rare symptom of nasopharyngeal carcinoma, a common tumor in Taiwan. We describe two patients with nasopharyngeal carcinoma who presented with frequent syncopal attacks five months before the diagnosis was made. We postulate that the mechanism of syncope is involvement of the glossopharyngeal or vagal nerv...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/0303-8467(94)90051-5
更新日期:1994-05-01 00:00:00
abstract::The authors present a case history of a meningeal arteriovenous malformation, presenting as a pseudotumor cerebri syndrome. Subarachnoid hemorrhage did not occur and brain configuration was normal on CT-scan. The pathogenesis of papilledema in this case is discussed. Probably the cause must be sought in the massive ov...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/0303-8467(80)90006-2
更新日期:1980-01-01 00:00:00
abstract::No specific treatment exists for patients with multiple sclerosis (MS) who fail to respond to conventional immunosuppressive and immunomodulating modalities. Furthermore, no method is available for regeneration of existing defect in the central nervous system (CNS). The ultimate goals of MS treatment, similarly to oth...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/j.clineuro.2008.01.014
更新日期:2008-11-01 00:00:00
abstract::A brain tumor in a 4-year-old child is described. The neoplasm was partly cystic and showed an a-typical multi-differentiated aspect. Microscopically the neoplasm had a clear-cut 'malignant' morphology. This tumor represents possibly a partly maturated primitive neuroectodermal brain tumor. The term PNET is briefly di...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/s0303-8467(86)80011-7
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:This study was performed to evaluate the association between red blood cell distribution width (RDW) and 3-month mortality in patients with aneurysmal subarachnoid hemorrhage. PATIENTS AND METHODS:This observational study was performed from March 2007 to May 2017 in an emergency department. The baseline cha...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2018.06.044
更新日期:2018-09-01 00:00:00
abstract::A 19-year-old previously healthy woman developed meningitis due to Acinetobacter calcoaceticus. This is a Gram-negative coccobacillus belonging to the family Neisseriaceae. Most reported cases of Acinetobacter meningitis were hospital-acquired and due to strains highly resistant to amoxycillin. Our patient was treated...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/0303-8467(93)90096-y
更新日期:1993-03-01 00:00:00
abstract::The case of a solitary cerebellar abscess in a 36-year-old Rwandese male is described. First it was considered to be tuberculosis, but at microscopal examination of the lesion after neurosurgical excision the true germ was found: Blastomyces dermatitidis. This solitary intracerebellar blastomycosis abscess is only the...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/s0303-8467(86)80031-2
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:Information on the nature and relative frequency of diagnoses made in referrals to neurology outpatient clinics is an important guide to priorities in services, teaching and research. Previous studies of this topic have been limited by being of only single centres or lacking in detail. We aimed to describe th...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,多中心研究
doi:10.1016/j.clineuro.2010.05.011
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To report the technical nuances and clinical outcomes of posterior atlantoaxial facet joint reduction, fixation and fusion (AFRF) technique as a revision procedure for BI and AAD patients with failed suboccipital decompression and large occipital bone defect. PATIENTS AND METHODS:We reviewed 32 patients with...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2020.105793
更新日期:2020-07-01 00:00:00
abstract::Three cases of spinal cord compression due to solitary osteochondroma of the spine are reported. The rarity and benign nature of the tumour is stressed. Other reported cases are reviewed. ...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/0303-8467(85)90113-1
更新日期:1985-01-01 00:00:00
abstract::Disulfiram in generally accepted maintenance doses in alcoholism may produce a rather severe polyneuropathy. In addition to the 39 literature cases, 5 personal patients were examined. Detailed clinical findings are given and the frequent permanent sequelae are emphasized. In 2 patients sural nerve biopsies were studie...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/0303-8467(84)90070-2
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:To study the expression of Akt2 and activation of PI3K in different grades of human gliomas and correlate the Akt2 expression with the proliferation activity of gliomas. METHODS:Akt2 expression and PI3K activity were examined in 48 different grades of human glioma specimens and six normal brain tissue sample...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2010.01.003
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:Awake craniotomy is a well-established procedure in surgery of intracranial tumors in eloquent areas. However, sufficiently standardized instruments for the assessment of sensory-motor function before, during and after the operation are currently lacking, despite their importance for evaluation of operative ...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2016.05.022
更新日期:2016-08-01 00:00:00
abstract::We report a patient with seizures and a single ringlike enhancing lesion on MRI that resembled a low-grade glioma. The patient received a diagnostic trial with albendazole on the assumption that this lesion could be a cysticercus. Follow-up showed resolution of the brain lesion in 4 weeks. Albendazole administration t...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/0303-8467(95)00044-k
更新日期:1995-08-01 00:00:00
abstract::Involvement of those cranial nerves subserving taste is common in the Guillain-Barré syndrome, yet seldom reported are disturbances of taste. This may reflect relative sparing of taste fibers, which are small thinly myelinated fibers. However, the true incidence of taste disturbances in GBS is probably underestimated ...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/0303-8467(90)90012-t
更新日期:1990-01-01 00:00:00
abstract::Stereotactic implantation of depth electrodes for surgical evaluation of drug-resistant epilepsy is the technique of choice in many centers across the world. Historically, the choice of depth versus subdural electrodes has been largely dependent on the training of epileptologists and epilepsy surgeons in light of thei...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
doi:10.1016/j.clineuro.2019.105640
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVE:The present study aims to investigate the relationship between transcallosal interhemispheric connectivity (IC) and hemispheric language lateralization by using a novel approach including repetitive navigated transcranial magnetic stimulation (rTMS), hemispheric dominance ratio (HDR) calculation, and rTMS-bas...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2015.12.010
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:Whether and when cervical disc arthroplasty (CDA) could be indicated for preoperative cervical spine kyphosis is unclear. The purpose of the study was to compare the clinical and radiological outcomes of single-level CDA and single-level anterior cervical discectomy and fusion (ACDF) in the patient with preop...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2021.106493
更新日期:2021-01-18 00:00:00
abstract::For the first time, Kluver Bucy syndrome (KBS) is described in young children who had no environmental learning of sex. The syndrome has so far been noted only in adults after bilateral temporal lobe affection. A few of its components, especially the hypersexuality and hypermetamorphosis, are likely to manifest differ...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/s0303-8467(98)00055-9
更新日期:1998-12-01 00:00:00
abstract:PURPOSE:To investigate imaging findings, risk factors and outcome in patients with cerebral venous thrombosis (CVT). METHODS:Records of all patients with diagnosis of CVT between 1992 and 2002 were reviewed. Patients with CNS infection and with CVT secondary to invasive procedures were excluded. Inherited and acquired...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2004.10.004
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:Aneurysmal subarachnoid hemorrhage (aSAH) is an often devastating form of stroke. Aside from the initial hemorrhage, cardiac complications can occur resulting in neurogenic stress cardiomyopathy (NCM), leading to impaired cardiac function. We investigated whether aSAH patients with NCM had poorer long term f...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2012.09.006
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:We performed a retrospective study to identify factors associated with preoperative and late postoperative seizures in primary supratentorial meningiomas. PATIENTS AND METHODS:Between July 2003 and December 2014, we extracted 303 consecutive patients who underwent primary resection for supratentorial meningi...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2019.03.007
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Longstanding overt vetriculomegaly in adults (LOVA) is a type of chronic hydrocephalus presumed to begin during infancy, which manifests in adults after a long and slow clinical course. Only a quite small number of LOVA case series have been published, controversies regarding optimal management still exist. T...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2019.05.014
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:Vascular cognitive impairment associated with small vessel disease (sVCI) may manifest as both cognitive and motor dysfunctions. However, few instruments exist for systematically assessing motor symptoms in sVCI, even though many neuropsychological tests exist to evaluate cognitive function. We developed a ne...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2010.11.001
更新日期:2011-04-01 00:00:00
abstract::We investigated the expression of c-myc and c-sis/PDGF mRNA and protein products in 20 cases of meningiomas of various grades: 10 benign, 5 atypical and 5 anaplastic meningiomas. All cases of atypical and anaplastic meningiomas were positive for c-myc protein and mRNA by immunohistochemistry and in situ hybridisation,...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/s0303-8467(00)00119-0
更新日期:2001-04-01 00:00:00
abstract:PURPOSE:Presacral schwannomas are rare tumors. Due to their benign nature and slow growth, these tumors are often giant and become difficult to treat. Their removal is a surgical challenge with different strategies reported in the literature. This study presents the consecutives cases of presacral schwannomas operated ...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2020.106409
更新日期:2021-01-01 00:00:00
abstract::The epidemiology and radiological features of Moyamoya disease (MMD) in the US were investigated. This study encompassed 98 cases; 26 were newly collected from eight US institutions and 72 were previously reported in the US literature. The patients ranged in age from 6 months to 67 years with age peaks in the first, t...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/s0303-8467(97)00060-7
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVE:To analyse the prevalence and incidence of dementia in a population of community-dwelling elderly (aged 75-80), living in socio-economically differing districts of Antwerp (Belgium), taking into account possible gender and educational differences. METHODS:A longitudinal cohort study (N=825) with a 3-year fol...
journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2011.07.030
更新日期:2011-11-01 00:00:00