Clinical significance of Ki-67 staining index in acoustic neurinoma.

Abstract:

:The correlation between various clinical parameters and MIB-1 (Ki-67) staining indices was evaluated in 58 acoustic neurinomas. The index ranged from 0.37% to 6.61% (mean 1.70%), and did not correlate with age, sex, or initial tumor volume. Sixteen of the 18 tumors removed subtotally or partially showed regrowth, and two showed a volume reduction. The 16 patients with regrowth were divided into two groups according to Ki-67 staining index, < 2.00% and > or = 2.00%. These groups had a significant difference in tumor doubling time (TDT). In addition, there was a significant logarithmic correlation between Ki-67 staining index and TDT. Ki-67 staining index can be used as an index of regrowth rate in partially or subtotally removed acoustic neurinomas. Intraoperative assessment of Ki-67 staining index may be useful for better management planning as well as the estimation of prognosis.

authors

Yokoyama M,Matsuda M,Nakasu S,Nakajima M,Handa J

doi

10.2176/nmc.36.698

subject

Has Abstract

pub_date

1996-10-01 00:00:00

pages

698-702; discussion 702-3

issue

10

eissn

0470-8105

issn

1349-8029

pii

JST.Journalarchive/nmc1959/36.698

journal_volume

36

pub_type

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