Abstract:
:The morphological changes in the vascular endothelium caused by the administration of tumor necrosis factor-alpha (TNF-alpha) were studied in an experimental model of rat brain tumors. Wistar rats bearing implanted C6 glioma received human natural-type TNF-alpha (1.7 x 10(5) U/m2) through the carotid artery and were sacrificed 3 or 24 hours later. The endothelial cells of the tumor blood vessels, demonstrated by the immunoreaction to factor VIII-related antigen, were enlarged after TNF-alpha administration. Morphometry demonstrated that the nuclei of these endothelial cells were also increased in size. The endothelial cells in the brain remote to the tumor were not affected. An in vitro binding study demonstrated that TNF-alpha binding sites were distributed in the vascular endothelial cells within the tumor but not in the brain remote to the tumor. The selective effect of TNF-alpha on the tumor blood vessels in experimental brain tumors may be related to the selective distribution of the TNF-alpha binding site.
journal_name
Neurol Med Chir (Tokyo)journal_title
Neurologia medico-chirurgicaauthors
Isaka T,Yoshimine T,Maruno M,Hayakawa Tdoi
10.2176/nmc.36.423subject
Has Abstractpub_date
1996-07-01 00:00:00pages
423-7issue
7eissn
0470-8105issn
1349-8029pii
JST.Journalarchive/nmc1959/36.423journal_volume
36pub_type
杂志文章abstract::A 29-year-old right-handed male with a 12-year education presented with a 2-month history of generalized epileptic activity. Neuroradiological imaging demonstrated a large lesion in the left frontal lobe involving the insulooperculum and in the temporal tip. Neurological and neuropsychological examination revealed no ...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.38.503
更新日期:1998-08-01 00:00:00
abstract::A 38-year-old woman presented with a case of post-traumatic ethmoidal cerebrospinal fluid (CSF) leak that was repaired using a purely endoscopic endonasal approach. Six weeks after a mild domestic maxillofacial trauma, she started complaining of clear, watery discharge from the left nostril and headache. Neuroimaging ...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.51.222
更新日期:2011-01-01 00:00:00
abstract::The management, analysis, and integration of Big Data have received increasing attention in healthcare research as well as in medical bioinformatics. The J-ASPECT study is the first nationwide survey in Japan on the real-world setting of stroke care using data obtained from the diagnosis procedure combination-based pa...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章,评审
doi:10.2176/nmc.ra.2016-0174
更新日期:2016-11-15 00:00:00
abstract::The prognostic significance of the variety of changes in the internal auditory meatus (IAM) caused by vestibular schwannoma was retrospectively analyzed in 69 consecutive patients with vestibular schwannoma. Preoperative bone-window computed tomography was used to classify IAM changes into extensive destruction (17%),...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.42.465
更新日期:2002-11-01 00:00:00
abstract::Neural progenitor cells (NPCs) are expected to be useful donor sources for cell transplantation therapy in Parkinson's disease. However, control of the differentiational lineage, especially into dopaminergic neurons, is still difficult. Thus, genetic modification of NPCs to produce l-dopa is potentially useful. The pr...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.44.344
更新日期:2004-07-01 00:00:00
abstract::Cine-magnetic resonance (MR) imaging examinations were performed in 10 patients with middle cranial fossa arachnoid cysts to evaluate communication between the cysts and the normal cerebrospinal fluid (CSF) space. Eight of 10 patients were evaluated by time of flight cine-MR imaging, and two by phase contrast cine-MR ...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.36.353
更新日期:1996-06-01 00:00:00
abstract::Parent artery occlusion (PAO) is an alternative to surgical clipping or endovascular endosaccular coil embolization for the management of cerebral aneurysms. Most giant and fusiform aneurysms are not amenable to endosaccular coil embolization due to anatomical considerations, such as a broad-neck. However, majority of...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract::Immunohistochemical localization of prostaglandin (PG) F2 alpha synthesized during recirculation following experimental forebrain ischemia was studied in Mongolian gerbils. The bilateral carotid arteries were clamped for 5 minutes, and the brains were frozen in situ after 5 minutes of recirculation. Sham-operated gerb...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.30.223
更新日期:1990-04-01 00:00:00
abstract::The incidence of spontaneous intracerebral hematoma (SICH) is even now high worldwide, especially higher in Japan than in Western countries, despite the development of advances in blood pressure (BP) management and food/alcohol intake education. Although mortality and morbidity for SICH are high, some controversies re...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章,评审
doi:10.2176/nmc.ra.2016-0327
更新日期:2017-11-15 00:00:00
abstract::A 62-year-old woman presented with a rare case of subependymoma associated with prominent Rosenthal fibers located in the left lateral ventricle manifesting as right hemiparesis and mild motor aphasia. The tumor was well demarcated and consisted of clusters of round nuclei embedded in an abundant gliofibrillary matrix...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.50.933
更新日期:2010-01-01 00:00:00
abstract::The authors report four cases of intracranial hemorrhage associated with nontraumatic disseminated intravascular coagulation (DIC). Two cases demonstrated a sudden onset of intracerebral hemorrhage. The other two showed chronic subdural hematoma initially, followed by acute multiple intracranial hemorrhages or general...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.30.610
更新日期:1990-08-01 00:00:00
abstract::An 88-year-old woman presented with a supratentorial primitive neuroectodermal tumor (PNET) manifesting as disturbance of consciousness and left hemiplegia. Magnetic resonance imaging showed a large mass lesion in the right frontotemporal region. She underwent biopsy of the lesion that confirmed the diagnosis of PNET....
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.45.530
更新日期:2005-10-01 00:00:00
abstract::A 58-year-old female, who had suffered from Weber-Christian disease for 26 years, presented with subarachnoid hemorrhage. Cerebral angiography showed dilatation of the basilar tip. An operation was performed in the chronic stage. The wall of dilated basilar artery was tough, but that of the right superior cerebellar a...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.35.454
更新日期:1995-07-01 00:00:00
abstract::A 65-year-old female developed hyperperfusion syndrome following carotid endarterectomy for severe stenosis of the left internal carotid artery. Transcranial Doppler monitoring showed a sharp increase in flow velocity in the middle cerebral artery (MCA). Diffusion-weighted magnetic resonance (MR) imaging demonstrated ...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.38.557
更新日期:1998-09-01 00:00:00
abstract::The intralaminar screw construct has been recently introduced in C6-C7 fixation. The aim of the study is to compare the stability afforded by three different C7 posterior fixation techniques using a three-dimensional finite element model of a C6-C7 cervical spine motion segment. Finite element models representing thre...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.oa.2013-0004
更新日期:2014-01-01 00:00:00
abstract::A 28-year-old woman presented with a rare case of endodermal cyst located ventral to the lower brain stem manifesting as recurrent aseptic meningitis. Computed tomography and magnetic resonance imaging demonstrated a cystic mass located ventral to the lower brain stem and extending from the prepontine to the upper cer...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.46.614
更新日期:2006-12-01 00:00:00
abstract::A 76-year-old male developed left hemiparesis in July 1991. The diagnosis was thrombosed giant vertebral artery aneurysm. He showed progressive symptoms and signs of brainstem compression, but refused surgery and was followed up without treatment. He died of rupture of the aneurysm and underwent autopsy in March 1995....
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.38.860
更新日期:1998-12-01 00:00:00
abstract::A 39-year-old male presented with a spinal neurinoma originating from the T-1 anterior root and located ventral to the spinal cord. The tumor was removed by hemilaminectomy with only partial facetectomy without costotransversectomy. No stabilization was necessary, and no complications secondary to surgery occurred. Co...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.39.685
更新日期:1999-09-01 00:00:00
abstract::Two cases of cloverleaf skull syndrome are reported. The patients were born with trilobed deformity of the skull associated with synostosis of the lambdoidal, coronal, and sagittal sutures in Case 1 and of the lambdoidal suture in Case 2. Both patients had hydrocephalus, low-set ears, and ocular hypertelorism. Ventric...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章,评审
doi:10.2176/nmc.29.746
更新日期:1989-08-01 00:00:00
abstract::A 52-year-old woman presented with a partially thrombosed giant aneurysm of the vertebral artery (VA) manifesting as a 3-month history of left hemiparesis. She developed subarachnoid hemorrhage during hospitalization and underwent emergency surgery for surgical proximal clipping and ventricular drainage with decompres...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.48.515
更新日期:2008-01-01 00:00:00
abstract::A 74-year-old male was admitted because of severe headache, vertigo, and vomiting. A computed tomographic scan showed heterogeneously enhanced tumors in the supra- and the infratentorial regions, apparently attached to the cerebellar tentorium. He died 2 months after the onset despite external decompression and a vent...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.30.334
更新日期:1990-05-01 00:00:00
abstract::A 61-year-old woman suffered transient mydriasis and prolonged facial nerve palsy after intracisternal papaverine application subsequent to elective clipping of an unruptured middle cerebral artery aneurysm. The mydriasis resolved within 90 minutes, but the facial nerve dysfunction persisted for 2 months before comple...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.42.565
更新日期:2002-12-01 00:00:00
abstract::Twenty-eight patients with spontaneous carotid-cavernous sinus fistulas (CCFs) were treated using a variety of techniques. Three of four patients with direct CCFs underwent intravascular embolization with a detachable balloon. Embolization with polyvinyl alcohol particles through an external carotid endoarterial route...
journal_title:Neurologia medico-chirurgica
pub_type: 临床试验,杂志文章
doi:10.2176/nmc.34.597
更新日期:1994-09-01 00:00:00
abstract::A 21-year-old woman presented with cervical myelopathy due to nontraumatic cervical disc herniation associated with cervical canal stenosis. The patient underwent removal of the herniated disc and anterior fusion with an autogenous iliac crest bone graft. After surgery, the patient showed satisfactory improvement. Cas...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章,评审
doi:10.2176/nmc.52.652
更新日期:2012-01-01 00:00:00
abstract::A huge uncal branch of the anterior choroidal artery was found in one of 22 cerebral hemispheres. The uncal artery measured 0.7 mm in diameter. It gave off small branches to the uncus, as well as a large parahippocampal artery, the accessory anterior temporal artery, and the anterior hippocampal artery. This uncal art...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章,评审
doi:10.2176/nmc.34.423
更新日期:1994-07-01 00:00:00
abstract::A 31-year-old woman with moyamoya disease presented with choreiform movements persisting for 4.5 years. Magnetic resonance imaging showed a fine vascular plexus in the base of the brain but no parenchymal brain damage. Cerebral angiography revealed intracranial vascular abnormalities compatible with moyamoya disease. ...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.48.390
更新日期:2008-09-01 00:00:00
abstract::Hyperthermia is becoming a potent therapeutic method for malignant brain tumors, either alone or in combination with radiation therapy. The heat response of organized tissues includes other factors besides the inherent cellular thermosensitivity, that is, tissue pH, PaO2, and nutrient supply, all of which are largely ...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.30.923
更新日期:1990-11-01 00:00:00
abstract::Twelve patients with growth hormone-producing pituitary adenomas were investigated to evaluate correlations between magnetic resonance (MR) appearance and tissue characteristics, sellar expansion, suprasellar tumor extension, and tumor consistency. MR imaging could detect microadenomas with a characteristic enhancemen...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.33.81
更新日期:1993-02-01 00:00:00
abstract::Cerebrovascular disease is a lethal complication for patients with renal failure because of the hemostatic disturbance and equivocality about management of the central nervous system. Appropriate management of the renal failure in neurosurgical patients was considered on the basis of experience. Hemodialysis (HD), whi...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.31.899
更新日期:1991-12-01 00:00:00
abstract::A female baby was born at 37 weeks and 6 days gestation by vaginal delivery with omphalocele, exstrophy of the cloaca, and imperforate anus, indicating the presence of OEIS complex, a rare combination of defects consisting of omphalocele (O), exstrophy of the cloaca (E), imperforate anus (I), and spinal deformity (S),...
journal_title:Neurologia medico-chirurgica
pub_type: 杂志文章
doi:10.2176/nmc.49.487
更新日期:2009-10-01 00:00:00