Abstract:
:With efforts underway to develop a preventive human immunodeficiency virus type 1 (HIV-1) vaccine, it remains unclear which immune responses are sufficient to protect against infection and whether prior HIV-1 immunity can alter the subsequent course of HIV-1 infection. We investigated these issues in the context of a volunteer who received six HIV-1LAI envelope immunizations and 10 weeks thereafter acquired HIV-1 infection through a high-risk sexual exposure. In contrast to nonvaccinated acutely infected individuals, anamnestic HIV-1-specific B- and T-cell responses appeared within 3 weeks in this individual, and neutralizing antibody preceded CD8+ cytotoxic responses. Despite an asymptomatic course and an initial low level of detectable infectious virus, a progressive CD4+ cell decline and dysfunction occurred within 2 years. Although vaccination elicited immunity to HIV-1 envelope, which was recalled upon HIV-1 exposure, it was insufficient to prevent infection and subsequent immunodeficiency.
journal_name
Proc Natl Acad Sci U S Aauthors
McElrath MJ,Corey L,Greenberg PD,Matthews TJ,Montefiori DC,Rowen L,Hood L,Mullins JIdoi
10.1073/pnas.93.9.3972subject
Has Abstractpub_date
1996-04-30 00:00:00pages
3972-7issue
9eissn
0027-8424issn
1091-6490journal_volume
93pub_type
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