Spontaneous regression of chemotherapy-refractory non-Hodgkin's lymphoma preceding the development of secondary leukaemia.

Abstract:

:In this report a rare case of spontaneous regression of a long-standing chemotherapy resistant low grade non-Hodgkin's lymphoma (NHL) of follicular small cleaved cell type is described. Extensive bulky lymphadenopathy substantially resolved, 7 months before the diagnosis of acute myelomonocytic leukaemia was established, in the absence of further treatment. It is possible that in this case the mutagenic effects of alkylating agents given during the course of the NHL reprogrammed lineage commitment in an early progenitor cell, deviating potential B-lineage cells along the myelomonocytic pathway.

journal_name

Leuk Lymphoma

journal_title

Leukemia & lymphoma

authors

Grigg AP,Gascoyne RD,Barnett MJ

doi

10.3109/10428199609051631

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

351-3

issue

3-4

eissn

1042-8194

issn

1029-2403

journal_volume

20

pub_type

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