Abstract:
:According to the International Workshop on Chronic Lymphocytic Leukemia/National Institutes of Health (iwCLL/NIH) guidelines for the diagnosis and treatment of chronic lymphocytic leukemia (CLL), bone marrow biopsy (BMB) is not required at diagnosis, however recommended before initiating treatment. That notwithstanding, histopathological examination of the BMB has the potential to provide important information of both clinical and biological significance. Here we attempt a reappraisal of the role of BMB examination in the modern diagnostic work-up of patients with CLL, based on both the literature and our accumulated experience from the systematic and multiparametric evaluation of a large series of BMB samples taken at diagnosis of CLL. Overall, we argue that the study of BMB offers important information not only for diagnostic purposes but also for elucidating CLL pathobiology.
journal_name
Leuk Lymphomajournal_title
Leukemia & lymphomaauthors
Baliakas P,Kanellis G,Stavroyianni N,Fameli M,Anagnostopoulos A,Stamatopoulos K,Papadaki Tdoi
10.3109/10428194.2013.780653subject
Has Abstractpub_date
2013-11-01 00:00:00pages
2377-84issue
11eissn
1042-8194issn
1029-2403journal_volume
54pub_type
杂志文章,评审abstract::The purpose of this phase 2 study was to determine the activity and safety of six cycles of bendamustine and eight rituximab (RB) as first-line treatment of adult patients with advanced stage non-follicular indolent non-Hodgkin lymphomas (INFL). The primary end-point was the complete response rate (CRR) with expected ...
journal_title:Leukemia & lymphoma
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abstract::We report a case of Epstein-Barr virus (EBV)-associated lymphoproliferative disorder (LPD) which developed after chemotherapy for hemophagocytic lymphohistiocytosis (HLH), who had no history of immunodeficiency or familial X-linked LPD. In HLH, the presence of EBV in T-cells was confirmed by a combination of in situ h...
journal_title:Leukemia & lymphoma
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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