Metallothionein-I + II and receptor megalin are altered in relation to oxidative stress in cerebral lymphomas.

Abstract:

:Primary central nervous system lymphoma (PCNSL) in immunocompetent patients is highly malignant and has a poor prognosis. The PCNSL molecular features are reminiscent to some degree of diffuse large B-cell lymphoma (DLBCL), yet PCNSL shows unique molecular profiles and a distinct clinical behavior. This article characterizes the histopathology and expression profiles of metallothionein-I + II (MT-I + II) and their receptor megalin along with proliferation, oxidative stress, and apoptosis in PCNSL and in central nervous system (CNS) lymphomas due to relapse from DLBCL (collectively referred to as CNS lymphoma). We show for the first time that MT-I + II and megalin are significantly altered in CNS lymphoma relative to controls (reactive lymph nodes and non-lymphoma brain tissue with neuropathology). MT-I + II are secreted in the CNS and are found mainly in the lymphomatous cells, while their receptor megalin is increased in cerebral cells. This morphology likely reflects the CNS lymphoma microenvironment and molecular interactions between lymphomatous and neuronal cells.

journal_name

Leuk Lymphoma

journal_title

Leukemia & lymphoma

authors

Pedersen MØ,Hansen PB,Nielsen SL,Penkowa M

doi

10.3109/10428190903518329

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

314-28

issue

2

eissn

1042-8194

issn

1029-2403

journal_volume

51

pub_type

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