Abstract:
:The transcriptional factor SOX11 is a disease-defining antigen in mantle cell lymphoma (MCL) and absent in most non-malignant tissues. To explore the role of SOX11-related cell signaling, and potentially take benefit from these for targeted therapy, associated networks and proteins need to be defined. In this study, we used an inducible SOX11 knock-down system followed by gene expression analysis to identify co-regulated genes and associated signaling pathways. A limited number (n = 27) of significantly co-regulated genes were identified, including SETMAR, HIG-2, and CD24. Further analysis confirmed co-regulation of SOX11 with HIG-2 and CD24 at the protein level. Of major interest, knock-down of HIG-2 reduced SOX11 levels and increased proliferation, the proteins are thus cross-regulated. HIG-2 was localized at the plasma cell membrane in both cell lines and primary MCL cells, and could potentially be of interest for targeted therapy.
journal_name
Leuk Lymphomajournal_title
Leukemia & lymphomaauthors
Kuci V,Nordström L,Conrotto P,Ek Sdoi
10.3109/10428194.2015.1121257subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1883-92issue
8eissn
1042-8194issn
1029-2403journal_volume
57pub_type
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