Different functional states of topoisomerase II can be discriminated by orthovanadate sensitivity in multi-drug resistant human leukemic cells.

Abstract:

:We have studied the functional properties of topoisomerase II (Topo II) in a subclone of the HL-60 cell line, which is highly resistant to cytotoxic Topo II inhibitors, but does not express p-glycoprotein. The cells contain the two forms of human topo II with Mr 170 and 180 kDa in equal proportions. Two different states of both forms of the enzymes can be separated by anion-exchange chromatography and functionally discriminated on the basis of orthovanadate sensitivity. The EC50 of orthovanadate was 0.2 microM for the early eluting and 30 microM for the late eluting Topo II.

journal_name

Leuk Lymphoma

journal_title

Leukemia & lymphoma

authors

Boege F,Gieseler F,Biersack H,Meyer P

doi

10.3109/10428199309148538

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

381-3

issue

4-5

eissn

1042-8194

issn

1029-2403

journal_volume

9

pub_type

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